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acs-7 Acyl-CoA synthetase 7 [ Caenorhabditis elegans ]

Gene ID: 174472, updated on 4-Jan-2025

Summary

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Official Symbol
acs-7
Official Full Name
Acyl-CoA synthetase 7
Primary source
WormBase:WBGene00007228
Locus tag
CELE_C01G6.7
See related
AllianceGenome:WB:WBGene00007228
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Enables medium-chain fatty acid-CoA ligase activity. Involved in ascaroside biosynthetic process. Located in peroxisome. Is expressed in intestinal cell. [provided by Alliance of Genome Resources, Jan 2025]
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Genomic context

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See acs-7 in Genome Data Viewer
Location:
chromosome: II
Exon count:
6
Sequence:
Chromosome: II; NC_003280.10 (9292017..9294033)

Chromosome II - NC_003280.10Genomic Context describing neighboring genes Neighboring gene Methionine synthase reductase Neighboring gene pseudo Neighboring gene ncRNA Neighboring gene Golgi apparatus protein 1 Neighboring gene Tyrosine-protein kinase receptor cam-1 Neighboring gene ncRNA Neighboring gene WD_REPEATS_REGION domain-containing protein

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003280.10

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Biosynthesis of Modular Ascarosides in C. elegans. Panda O, et al. Angew Chem Int Ed Engl, 2017 Apr 18. PMID 28371259, Free PMC Article
  2. A Large Family of Enzymes Responsible for the Modular Architecture of Nematode Pheromones. Faghih N, et al. J Am Chem Soc, 2020 Aug 12. PMID 32702987, Free PMC Article
  3. Biosynthetic tailoring of existing ascaroside pheromones alters their biological function in C. elegans. Zhou Y, et al. Elife, 2018 Jun 4. PMID 29863473, Free PMC Article
  4. New Roles for the Heterochronic Transcription Factor LIN-29 in Cuticle Maintenance and Lipid Metabolism at the Larval-to-Adult Transition in Caenorhabditis elegans. Abete-Luzi P, et al. Genetics, 2020 Mar. PMID 31974205, Free PMC Article
  5. Gene regulatory network inference in long-lived C. elegans reveals modular properties that are predictive of novel aging genes. Suriyalaksh M, et al. iScience, 2022 Jan 21. PMID 35036864, Free PMC Article

See all (9) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables CoA-ligase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables catalytic activity IEA
Inferred from Electronic Annotation
more info
  
enables ligase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables ligase activity IEA
Inferred from Electronic Annotation
more info
  
enables medium-chain fatty acid-CoA ligase activity IDA
Inferred from Direct Assay
more info
 PubMed 
Process Evidence Code Pubs
involved_in ascaroside biosynthetic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in fatty acid biosynthetic process IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in peroxisome IDA
Inferred from Direct Assay
more info
 PubMed 
located_in peroxisome IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
Acyl-CoA synthetase 7
NP_495979.1
  • Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003280.10 Reference assembly

    Range
    9292017..9294033
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_063578.7 → NP_495979.1  Acyl-CoA synthetase 7 [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_495979.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q17577
    Conserved Domains (1) summary
    cd05911
    Location:35 → 524
    Firefly_Luc_like; Firefly luciferase of light emitting insects and 4-Coumarate-CoA Ligase (4CL)
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q17577.1

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