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mdt-22 Mediator of RNA polymerase II transcription subunit 22 [ Caenorhabditis elegans ]

Gene ID: 174595, updated on 2-Nov-2024

Summary

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Official Symbol
mdt-22
Official Full Name
Mediator of RNA polymerase II transcription subunit 22
Primary source
WormBase:WBGene00007022
Locus tag
CELE_ZK970.3
See related
AllianceGenome:WB:WBGene00007022
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Predicted to enable transcription coregulator activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to be located in nucleus. Predicted to be part of mediator complex. Orthologous to human MED22 (mediator complex subunit 22). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See mdt-22 in Genome Data Viewer
Location:
chromosome: II
Exon count:
4
Sequence:
Chromosome: II; NC_003280.10 (10301216..10301888)

Chromosome II - NC_003280.10Genomic Context describing neighboring genes Neighboring gene Secreted protein Neighboring gene Neprilysin Neighboring gene ncRNA Neighboring gene ATP-dependent Clp protease proteolytic subunit 1, mitochondrial Neighboring gene ncRNA Neighboring gene tRNA-Pro Neighboring gene tRNA-Pro

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003280.10

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Surfeit locus gene homologs are widely distributed in invertebrate genomes. Armes N, et al. Mol Cell Biol, 1996 Oct. PMID 8816471, Free PMC Article
  2. Proteomic Interactome of C. elegans Mediator Complex Subunit 28 (MDT-28) Reveals Predominant Association with a Restricted Set of Core Mediator Subunits and an Affinity to Additional Structural and Enzymatic Proteins. Yilma P, et al. Folia Biol (Praha), 2019. PMID 32362303
  3. Transcriptional control of cell-cycle quiescence during C. elegans development. Clayton JE, et al. Dev Biol, 2008 Jan 15. PMID 18082681, Free PMC Article
  4. An ARC/Mediator subunit required for SREBP control of cholesterol and lipid homeostasis. Yang F, et al. Nature, 2006 Aug 10. PMID 16799563
  5. A unified nomenclature for protein subunits of mediator complexes linking transcriptional regulators to RNA polymerase II. Bourbon HM, et al. Mol Cell, 2004 Jun 4. PMID 15175151

See all (12) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
enables transcription coregulator activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in regulation of transcription by RNA polymerase II IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
part_of mediator complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of mediator complex IEA
Inferred from Electronic Annotation
more info
  
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
Mediator of RNA polymerase II transcription subunit 22
NP_496216.1
  • Partially confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003280.10 Reference assembly

    Range
    10301216..10301888
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_063815.6 → NP_496216.1  Mediator of RNA polymerase II transcription subunit 22 [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_496216.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q23679
    Conserved Domains (1) summary
    pfam06179
    Location:29 → 139
    Med22; Surfeit locus protein 5 subunit 22 of Mediator complex
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q23679.1

Gene LinkOut

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