cdc-48.1 Transitional endoplasmic reticulum ATPase homolog 1 [Caenorhabditis elegans] - Gene

Summary

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Official Symbol: cdc-48.1
Official Full Name: Transitional endoplasmic reticulum ATPase homolog 1
Primary source: WormBase:WBGene00007352
Locus tag: CELE_C06A1.1
See related: AllianceGenome:WB:WBGene00007352
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Caenorhabditis elegans (strain: Bristol N2)
Lineage: Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary: Enables ATP hydrolysis activity and identical protein binding activity. Involved in several processes, including ERAD pathway; determination of adult lifespan; and positive regulation of proteasomal ubiquitin-dependent protein catabolic process. Located in nucleoplasm and perinuclear region of cytoplasm. Part of VCP-NPL4-UFD1 AAA ATPase complex. Is expressed in several structures, including body wall musculature; germ line; and gonad. Human ortholog(s) of this gene implicated in several diseases, including Charcot-Marie-Tooth disease type 2Y; Paget's disease of bone; frontotemporal dementia and/or amyotrophic lateral sclerosis 6; inclusion body myopathy with early-onset Paget disease of bone with or without frontotemporal dementia 1; and inclusion body myositis. Orthologous to human VCP (valosin containing protein). [provided by Alliance of Genome Resources, Jan 2025]
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Genomic context

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See cdc-48.1 in Genome Data Viewer

Location:: chromosome: II

Exon count:: 5

Sequence:: Chromosome: II; NC_003280.10 (10560036..10563407, complement)

Chromosome II - NC_003280.10 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003280.10

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

The amount of UBXN-6 was markedly increased upon starvation, but not with the treatment of tunicamycin and rapamycin. The induction upon starvation is a unique characteristic for UBXN-6 among C-terminal cofactors of CDC-48.
Title: Functional characterization of UBXN-6, a C-terminal cofactor of CDC-48, in C. elegans.
A novel role for p97/CDC-48, whereby its role in protein degradation is integrated with its role in regulating expression of endoplasmic reticulum stress response genes.
Title: Genome-wide screen identifies a novel p97/CDC-48-dependent pathway regulating ER-stress-induced gene transcription.
In the presence of ATP, the N-D1 ring repeatedly rotates 23 degrees clockwise and resets relative to the D2 ring.
Title: High-speed atomic force microscopic observation of ATP-dependent rotation of the AAA+ chaperone p97.
All six UBXN proteins directly interacted with CDC-48.1, and simultaneous knockdown of the expression of three genes, ubxn-1, ubxn-2 and ubxn-3, induced embryonic lethal and sterile phenotypes, but knockdown of either one or two did not.
Title: Caenorhabditis elegans UBX cofactors for CDC-48/p97 control spermatogenesis.
Positive cooperativity of the p97 AAA ATPase is critical for essential functions.
Title: Positive cooperativity of the p97 AAA ATPase is critical for essential functions.
The C. elegans p97/CDC-48-UFD-1-NPL-4 complex controls the sperm-oocyte switch by regulating CUL-2-mediated TRA-1A proteasome degradation.
Title: Caenorhabditis elegans p97 controls germline-specific sex determination by controlling the TRA-1 level in a CUL-2-dependent manner.
ATX-3 interacts with both VCP/p97 worm homologs, CDC-48.1 and CDC-48.2 and the interaction domains were mapped.
Title: ATX-3, CDC-48 and UBXN-5: a new trimolecular complex in Caenorhabditis elegans.
These findings identified a role for CDC-48(UFD-1/NPL-4) in DNA replication, which is important for cell cycle progression and genome stability.
Title: Cell cycle progression requires the CDC-48UFD-1/NPL-4 complex for efficient DNA replication.
A novel signaling module involving CRP-1 and CDC-48 which may directly link the unfolded protein response to DNA remodeling and transcription control.
Title: GTPase-mediated regulation of the unfolded protein response in Caenorhabditis elegans is dependent on the AAA+ ATPase CDC-48.
These results indicate that both HMG-12 and CAR-1 play important roles in embryonic expression of cdc-48.1.
Title: Involvement of HMG-12 and CAR-1 in the cdc-48.1 expression of Caenorhabditis elegans.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

C06A1.6 (e-PCR)
- UniSTS:317265

C06A1.1 (e-PCR)
- UniSTS:308947

Homology

Orthologs from OrthoDB

Gene Ontology Provided by WormBase

Function	Evidence Code	Pubs
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables ATP hydrolysis activity	IBA Inferred from Biological aspect of Ancestor more info
enables ATP hydrolysis activity	IDA Inferred from Direct Assay more info	PubMed
enables ATP hydrolysis activity	IEA Inferred from Electronic Annotation more info
enables hydrolase activity	IEA Inferred from Electronic Annotation more info
enables identical protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables polyubiquitin modification-dependent protein binding	IBA Inferred from Biological aspect of Ancestor more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein-containing complex binding	IDA Inferred from Direct Assay more info	PubMed

Process	Evidence Code	Pubs
involved_in ERAD pathway	IGI Inferred from Genetic Interaction more info	PubMed
involved_in autophagosome maturation	IBA Inferred from Biological aspect of Ancestor more info
involved_in determination of adult lifespan	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in embryo development ending in birth or egg hatching	IGI Inferred from Genetic Interaction more info	PubMed
involved_in mitotic spindle disassembly	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of mitotic cell cycle, embryonic	IGI Inferred from Genetic Interaction more info	PubMed
involved_in positive regulation of proteasomal ubiquitin-dependent protein catabolic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in proteasome-mediated ubiquitin-dependent protein catabolic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of protein localization to chromatin	IGI Inferred from Genetic Interaction more info	PubMed
involved_in retrograde protein transport, ER to cytosol	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
part_of VCP-NPL4-UFD1 AAA ATPase complex	IBA Inferred from Biological aspect of Ancestor more info
part_of VCP-NPL4-UFD1 AAA ATPase complex	IDA Inferred from Direct Assay more info	PubMed
part_of VCP-NPL4-UFD1 AAA ATPase complex	IPI Inferred from Physical Interaction more info	PubMed
located_in cytoplasm	IDA Inferred from Direct Assay more info	PubMed
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
is_active_in cytosol	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleoplasm	IDA Inferred from Direct Assay more info	PubMed
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed
located_in perinuclear region of cytoplasm	IDA Inferred from Direct Assay more info	PubMed
located_in perinuclear region of cytoplasm	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: Transitional endoplasmic reticulum ATPase homolog 1

NP_496273.1

Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003280.10 Reference assembly

Range

10560036..10563407 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_063872.6 → NP_496273.1 Transitional endoplasmic reticulum ATPase homolog 1 [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_496273.1

Status: REVIEWED

UniProtKB/Swiss-Prot

P54811

Conserved Domains (5) summary

smart01072
Location:137 → 197

CDC48_2; Cell division protein 48 (CDC48) domain 2

TIGR01243
Location:52 → 775

CDC48; AAA family ATPase, CDC48 subfamily

pfam00004
Location:247 → 376

AAA; ATPase family associated with various cellular activities (AAA)

pfam02359
Location:31 → 112

CDC48_N; Cell division protein 48 (CDC48), N-terminal domain

pfam09336
Location:727 → 771

Vps4_C; Vps4 C terminal oligomerization domain