unc-53 Adapter protein unc-53;Calponin-homology (CH) domain-containing protein [Caenorhabditis elegans] - Gene

Summary

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Official Symbol: unc-53
Official Full Name: Adapter protein unc-53;Calponin-homology (CH) domain-containing protein
Primary source: WormBase:WBGene00006788
Locus tag: CELE_F45E10.1
See related: AllianceGenome:WB:WBGene00006788
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Caenorhabditis elegans (strain: Bristol N2)
Lineage: Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary: Predicted to enable actin filament binding activity. Involved in several processes, including backward locomotion; determination of muscle attachment site; and egg-laying behavior. Located in cytoplasm. Is expressed in several structures, including ganglia; hermaphrodite distal tip cell; neurons; non-striated muscle; and socket cell. Human ortholog(s) of this gene implicated in opiate dependence. Orthologous to several human genes including NAV1 (neuron navigator 1). [provided by Alliance of Genome Resources, Jan 2025]
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Genomic context

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See unc-53 in Genome Data Viewer

Location:: chromosome: II

Exon count:: 24

Sequence:: Chromosome: II; NC_003280.10 (11058047..11089456, complement)

Chromosome II - NC_003280.10 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003280.10

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

abl-1 negatively regulates unc-53 during DTC migrations and requirement of unc-53 function during both AP and DV DTC migrations could be due to unc-53 mediated regulation of unc-5 activity
Title: The unc-53 gene negatively regulates rac GTPases to inhibit unc-5 activity during Distal tip cell migrations in C. elegans.
interaction between NAV2 and 14-3-3epsilon
Title: 14-3-3ε and NAV2 interact to regulate neurite outgrowth and axon elongation.
UNC-53/NAV2, through its calponin homology domain, acts as a scaffold that links ABI-1 to the ARP2/3 complex to regulate actin cytoskeleton remodeling.
Title: The cell migration molecule UNC-53/NAV2 is linked to the ARP2/3 complex by ABI-1.

Submit: New GeneRIF Correction

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

F45E10.1 (e-PCR)
- UniSTS:311235

Homology

Orthologs from OrthoDB

Gene Ontology Provided by WormBase

Function	Evidence Code	Pubs
enables actin filament binding	TAS Traceable Author Statement more info	PubMed
enables calmodulin binding	IEA Inferred from Electronic Annotation more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in actin cytoskeleton organization	ISS Inferred from Sequence or Structural Similarity more info	PubMed
involved_in axon guidance	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in backward locomotion	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in cell projection morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in determination of muscle attachment site	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in egg-laying behavior	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in mating behavior	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in mesodermal cell migration	IGI Inferred from Genetic Interaction more info	PubMed
involved_in motor neuron axon guidance	IGI Inferred from Genetic Interaction more info	PubMed
involved_in nervous system development	IBA Inferred from Biological aspect of Ancestor more info
involved_in neurogenesis	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of axon extension	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of axon extension involved in axon guidance	IGI Inferred from Genetic Interaction more info	PubMed
involved_in positive regulation of axon extension involved in axon guidance	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of cell migration	IGI Inferred from Genetic Interaction more info	PubMed
involved_in positive regulation of multicellular organism growth	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in signal transduction	IPI Inferred from Physical Interaction more info	PubMed

Component	Evidence Code	Pubs
located_in cytoplasm	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: Adapter protein unc-53;Calponin-homology (CH) domain-containing protein

NP_001022169.1

Confirmed by transcript evidence

NP_001022170.1

Confirmed by transcript evidence

NP_001022171.1

Confirmed by transcript evidence

NP_001022172.1

Confirmed by transcript evidence

NP_001254271.1

Confirmed by transcript evidence

NP_001254272.1

Confirmed by transcript evidence

NP_001254273.1

Confirmed by transcript evidence

NP_741045.1

Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003280.10 Reference assembly

Range

11058047..11089456 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_171039.3 → NP_741045.1 Adapter protein unc-53 [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_741045.1

Status: REVIEWED

UniProtKB/Swiss-Prot

Q7YSI9

Conserved Domains (4) summary

smart00382
Location:1294 → 1400

AAA; ATPases associated with a variety of cellular activities

pfam00307
Location:11 → 110

CH; Calponin homology (CH) domain

cl11433
Location:1077 → 1134

DivIC; Septum formation initiator

cl21455
Location:1296 → 1400

P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases
NM_001267342.3 → NP_001254271.1 Calponin-homology (CH) domain-containing protein [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_001254271.1

Status: REVIEWED

UniProtKB/TrEMBL

G5EEU6

Conserved Domains (4) summary

smart00382
Location:1253 → 1359

AAA; ATPases associated with a variety of cellular activities

PHA03247
Location:436 → 622

PHA03247; large tegument protein UL36; Provisional

pfam00307
Location:13 → 116

CH; Calponin homology (CH) domain

pfam04977
Location:1036 → 1093

DivIC; Septum formation initiator
NM_001026998.5 → NP_001022169.1 Adapter protein unc-53 [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_001022169.1

Status: REVIEWED

UniProtKB/Swiss-Prot

Q7YSI9

Conserved Domains (4) summary

smart00382
Location:1260 → 1366

AAA; ATPases associated with a variety of cellular activities

pfam00307
Location:11 → 110

CH; Calponin homology (CH) domain

cl11433
Location:1043 → 1100

DivIC; Septum formation initiator

cl21455
Location:1262 → 1366

P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases
NM_001026999.8 → NP_001022170.1 Adapter protein unc-53 [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_001022170.1

Status: REVIEWED

UniProtKB/Swiss-Prot

Q7YSI0, Q7YSI9, Q7YXD0, Q8MLZ1, Q8MM94, Q8MV03

Conserved Domains (4) summary

smart00382
Location:1365 → 1471

AAA; ATPases associated with a variety of cellular activities

pfam00307
Location:11 → 110

CH; Calponin homology (CH) domain

cl11433
Location:1148 → 1205

DivIC; Septum formation initiator

cl21455
Location:1367 → 1471

P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases
NM_001267343.3 → NP_001254272.1 Calponin-homology (CH) domain-containing protein [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_001254272.1

Status: REVIEWED

UniProtKB/TrEMBL

G5EBX1

Conserved Domains (4) summary

smart00382
Location:1324 → 1430

AAA; ATPases associated with a variety of cellular activities

PHA03247
Location:436 → 855

PHA03247; large tegument protein UL36; Provisional

pfam00307
Location:13 → 116

CH; Calponin homology (CH) domain

pfam04977
Location:1107 → 1164

DivIC; Septum formation initiator
NM_001027000.6 → NP_001022171.1 Adapter protein unc-53 [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_001022171.1

Status: REVIEWED

UniProtKB/Swiss-Prot

Q7YSI9

Conserved Domains (3) summary

smart00382
Location:1231 → 1337

AAA; ATPases associated with a variety of cellular activities

cl11433
Location:1014 → 1071

DivIC; Septum formation initiator

cl21455
Location:1233 → 1337

P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases
NM_001267344.3 → NP_001254273.1 Adapter protein unc-53 [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_001254273.1

Status: REVIEWED

UniProtKB/TrEMBL

C8JQR2

Conserved Domains (3) summary

smart00382
Location:1057 → 1163

AAA; ATPases associated with a variety of cellular activities

cl11433
Location:840 → 897

DivIC; Septum formation initiator

cl21455
Location:1059 → 1163

P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases
NM_001027001.5 → NP_001022172.1 Adapter protein unc-53 [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_001022172.1

Status: REVIEWED

UniProtKB/Swiss-Prot

Q7YSI9

Conserved Domains (4) summary

smart00382
Location:945 → 1051

AAA; ATPases associated with a variety of cellular activities

pfam05823
Location:536 → 600

Gp-FAR-1; Nematode fatty acid retinoid binding protein (Gp-FAR-1)

cl11433
Location:728 → 785

DivIC; Septum formation initiator

cl21455
Location:947 → 1051

P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases