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mfn-1 Mitoferrin [ Caenorhabditis elegans ]

Gene ID: 174752, updated on 9-Dec-2024

Summary

Official Symbol
mfn-1
Official Full Name
Mitoferrin
Primary source
WormBase:WBGene00012204
Locus tag
CELE_W02B12.9
See related
AllianceGenome:WB:WBGene00012204
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Predicted to enable ferrous iron transmembrane transporter activity. Predicted to be involved in iron import into the mitochondrion. Predicted to be located in mitochondrial inner membrane. Predicted to be active in mitochondrial membrane. Is expressed in intestine and nervous system. Orthologous to several human genes including SLC25A28 (solute carrier family 25 member 28). [provided by Alliance of Genome Resources, Dec 2024]
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Genomic context

See mfn-1 in Genome Data Viewer
Location:
chromosome: II
Exon count:
4
Sequence:
Chromosome: II; NC_003280.10 (11470003..11472016, complement)

Chromosome II - NC_003280.10Genomic Context describing neighboring genes Neighboring gene Rho GTPase-activating protein 68F;Rho-GAP domain-containing protein Neighboring gene Kinesin motor domain-containing protein Neighboring gene CDGSH iron-sulfur domain-containing protein 2 homologue;Iron-binding zinc finger CDGSH type domain-containing protein Neighboring gene tRNA (guanine-N(7)-)-methyltransferase Neighboring gene Beta-1,4-N-acetylgalactosaminyltransferase Neighboring gene Uncharacterized protein

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

General gene information

Markers

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
enables ferrous iron transmembrane transporter activity IBA
Inferred from Biological aspect of Ancestor
more info
 
Process Evidence Code Pubs
involved_in iron import into the mitochondrion IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in iron ion transport IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
located_in mitochondrial inner membrane IEA
Inferred from Electronic Annotation
more info
 
is_active_in mitochondrial membrane IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in mitochondrion IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
Mitoferrin
NP_001382726.1
  • Partially confirmed by transcript evidence
NP_001391079.1
  • Partially confirmed by transcript evidence
NP_001391080.1
  • Partially confirmed by transcript evidence
NP_496447.1
  • Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003280.10 Reference assembly

    Range
    11470003..11472016 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_064046.7NP_496447.1  Mitoferrin [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_496447.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q23125
    Conserved Domains (1) summary
    pfam00153
    Location:14108
    Mito_carr; Mitochondrial carrier protein
  2. NM_001404239.1NP_001391079.1  Mitoferrin [Caenorhabditis elegans]

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A8D9I609
  3. NM_001404240.1NP_001391080.1  Mitoferrin [Caenorhabditis elegans]

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A8D9I610
  4. NM_001395808.1NP_001382726.1  Mitoferrin [Caenorhabditis elegans]

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A8D9I8L7
    Conserved Domains (1) summary
    PTZ00168
    Location:22193
    PTZ00168; mitochondrial carrier protein; Provisional