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mdt-8 Mediator of RNA polymerase II transcription subunit 8 [ Caenorhabditis elegans ]

Gene ID: 174763, updated on 2-Nov-2024

Summary

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Official Symbol
mdt-8
Official Full Name
Mediator of RNA polymerase II transcription subunit 8
Primary source
WormBase:WBGene00007013
Locus tag
CELE_Y62F5A.1
See related
AllianceGenome:WB:WBGene00007013
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Predicted to enable RNA polymerase II cis-regulatory region sequence-specific DNA binding activity and transcription coregulator activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to be located in nucleus. Predicted to be part of core mediator complex and mediator complex. Is expressed in intestine and pharynx. Orthologous to human MED8 (mediator complex subunit 8). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See mdt-8 in Genome Data Viewer
Location:
chromosome: II
Exon count:
4
Sequence:
Chromosome: II; NC_003280.10 (11527168..11533816, complement)

Chromosome II - NC_003280.10Genomic Context describing neighboring genes Neighboring gene Major sperm protein Neighboring gene ncRNA Neighboring gene Phosphatidylinositol 3-kinase age-1 Neighboring gene Tyrosine-protein phosphatase domain-containing protein Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene Reverse transcriptase domain-containing protein Neighboring gene Uncharacterized protein Neighboring gene ncRNA Neighboring gene ncRNA

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003280.10

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Proteomic Interactome of C. elegans Mediator Complex Subunit 28 (MDT-28) Reveals Predominant Association with a Restricted Set of Core Mediator Subunits and an Affinity to Additional Structural and Enzymatic Proteins. Yilma P, et al. Folia Biol (Praha), 2019. PMID 32362303
  2. Transcriptional control of cell-cycle quiescence during C. elegans development. Clayton JE, et al. Dev Biol, 2008 Jan 15. PMID 18082681, Free PMC Article
  3. An ARC/Mediator subunit required for SREBP control of cholesterol and lipid homeostasis. Yang F, et al. Nature, 2006 Aug 10. PMID 16799563
  4. A unified nomenclature for protein subunits of mediator complexes linking transcriptional regulators to RNA polymerase II. Bourbon HM, et al. Mol Cell, 2004 Jun 4. PMID 15175151
  5. Transcription mechanisms. Blackwell TK, et al. WormBook, 2006 Sep 5. PMID 18050436, Free PMC Article

See all (17) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables transcription coregulator activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables transcription coregulator activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in regulation of transcription by RNA polymerase II IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
part_of core mediator complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of mediator complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of mediator complex IEA
Inferred from Electronic Annotation
more info
  
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
Mediator of RNA polymerase II transcription subunit 8
NP_496463.2
  • Confirmed by transcript evidence
NP_496464.2
  • Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003280.10 Reference assembly

    Range
    11527168..11533816 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_064063.5 → NP_496464.2  Mediator of RNA polymerase II transcription subunit 8 [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_496464.2

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q9U1W2
    Conserved Domains (1) summary
    pfam10232
    Location:15 → 239
    Med8; Mediator of RNA polymerase II transcription complex subunit 8

  2. NM_064062.5 → NP_496463.2  Mediator of RNA polymerase II transcription subunit 8 [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_496463.2

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q9U1W2, Q9U1W3
    Conserved Domains (2) summary
    pfam10232
    Location:15 → 239
    Med8; Mediator of RNA polymerase II transcription complex subunit 8
    cl09930
    Location:241 → 295
    RPA_2b-aaRSs_OBF_like; Replication protein A, class 2b aminoacyl-tRNA synthetases, and related proteins with oligonucleotide/oligosaccharide (OB) fold.
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9U1W2.1

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