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kel-1 BTB domain-containing protein [ Caenorhabditis elegans ]

Gene ID: 174791, updated on 2-Nov-2024

Summary

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Official Symbol
kel-1
Official Full Name
BTB domain-containing protein
Primary source
WormBase:WBGene00002184
Locus tag
CELE_C47D12.7
See related
AllianceGenome:WB:WBGene00002184
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Predicted to enable ubiquitin-like ligase-substrate adaptor activity. Predicted to be involved in proteasome-mediated ubiquitin-dependent protein catabolic process. Predicted to be part of Cul3-RING ubiquitin ligase complex. Predicted to be active in cytoplasm. Is expressed in g1. Human ortholog(s) of this gene implicated in pseudohypoaldosteronism. Orthologous to several human genes including KLHL3 (kelch like family member 3). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See kel-1 in Genome Data Viewer
Location:
chromosome: II
Exon count:
9
Sequence:
Chromosome: II; NC_003280.10 (11688943..11696059)

Chromosome II - NC_003280.10Genomic Context describing neighboring genes Neighboring gene F-box domain-containing protein Neighboring gene CUB domain-containing protein Neighboring gene Threonine--tRNA ligase, cytoplasmic;threonine--tRNA ligase Neighboring gene ERCC4 domain-containing protein Neighboring gene inositol-3-phosphate synthase Neighboring gene ncRNA

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003280.10

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. kel-1, a novel Kelch-related gene in Caenorhabditis elegans, is expressed in pharyngeal gland cells and is required for the feeding process. Ohmachi M, et al. Genes Cells, 1999 Jun. PMID 10421842
  2. OrthoList: a compendium of C. elegans genes with human orthologs. Shaye DD, et al. PLoS One, 2011. PMID 21647448, Free PMC Article
  3. OrthoList 2: A New Comparative Genomic Analysis of Human and Caenorhabditis elegans Genes. Kim W, et al. Genetics, 2018 Oct. PMID 30120140, Free PMC Article
  4. Genome sequence of the nematode C. elegans: a platform for investigating biology. C. elegans Sequencing Consortium. Science, 1998 Dec 11. PMID 9851916

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
enables ubiquitin-like ligase-substrate adaptor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in proteasome-mediated ubiquitin-dependent protein catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
part_of Cul3-RING ubiquitin ligase complex IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
BTB domain-containing protein
NP_001254310.1
  • Confirmed by transcript evidence
NP_001254311.1
  • Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003280.10 Reference assembly

    Range
    11688943..11696059
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001267381.2 → NP_001254310.1  BTB domain-containing protein [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_001254310.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    G5EGS4
    Conserved Domains (2) summary
    PHA03098
    Location:82 → 603
    PHA03098; kelch-like protein; Provisional
    sd00038
    Location:367 → 410
    Kelch; KELCH repeat [structural motif]

  2. NM_001267382.3 → NP_001254311.1  BTB domain-containing protein [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_001254311.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    B7WN97
    Conserved Domains (2) summary
    PHA03098
    Location:1 → 104
    PHA03098; kelch-like protein; Provisional
    sd00038
    Location:5 → 46
    Kelch; KELCH repeat [structural motif]
Nucleotide Protein
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