gpb-1 Guanine nucleotide-binding protein subunit beta-1;WD_REPEATS_REGION domain-containing protein [Caenorhabditis elegans] - Gene

Summary

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Official Symbol: gpb-1
Official Full Name: Guanine nucleotide-binding protein subunit beta-1;WD_REPEATS_REGION domain-containing protein
Primary source: WormBase:WBGene00001679
Locus tag: CELE_F13D12.7
See related: AllianceGenome:WB:WBGene00001679
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Caenorhabditis elegans (strain: Bristol N2)
Lineage: Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary: Predicted to enable signaling receptor complex adaptor activity. Involved in several processes, including establishment of mitotic spindle orientation; negative regulation of locomotion; and regulation of egg-laying behavior. Predicted to be part of heterotrimeric G-protein complex. Predicted to be active in cytoplasm. Is expressed in several structures, including germ line; intestine; pharynx; seam cell; and vulval cell. Used to study cardiovascular system disease. Human ortholog(s) of this gene implicated in several diseases, including Charcot-Marie-Tooth disease dominant intermediate F; artery disease (multiple); autosomal dominant intellectual developmental disorder 42; congenital stationary night blindness 1H; and hematologic cancer (multiple). Orthologous to several human genes including GNB1 (G protein subunit beta 1) and GNB4 (G protein subunit beta 4). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See gpb-1 in Genome Data Viewer

Location:: chromosome: II

Exon count:: 10

Sequence:: Chromosome: II; NC_003280.10 (11742811..11748611, complement)

Chromosome II - NC_003280.10 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003280.10

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Data report that the distribution of the Gbeta subunit GPB-1, a negative regulator of force generators, varies across the cell cycle, with levels at the cell membrane being lowest during mitosis.
Title: Polarity mediates asymmetric trafficking of the Gbeta heterotrimeric G-protein subunit GPB-1 in C. elegans embryos.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

F13D12.7 (e-PCR)
- UniSTS:320040

STS2-1 (e-PCR)
- UniSTS:241763

STS2-195 (e-PCR)
- UniSTS:241868

Homology

Orthologs from OrthoDB

Gene Ontology Provided by WormBase

Function	Evidence Code	Pubs
enables signaling receptor complex adaptor activity	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in G protein-coupled receptor signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in cell cycle	IEA Inferred from Electronic Annotation more info
involved_in cell division	IEA Inferred from Electronic Annotation more info
involved_in embryo development ending in birth or egg hatching	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in establishment of mitotic spindle orientation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of locomotion	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of egg-laying behavior	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in signal transduction	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
part_of heterotrimeric G-protein complex	IBA Inferred from Biological aspect of Ancestor more info
part_of heterotrimeric G-protein complex	ISS Inferred from Sequence or Structural Similarity more info	PubMed

General protein information

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Preferred Names: Guanine nucleotide-binding protein subunit beta-1;WD_REPEATS_REGION domain-containing protein

NP_001366714.1

Confirmed by transcript evidence

NP_001379508.1

Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003280.10 Reference assembly

Range

11742811..11748611 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001393204.1 → NP_001379508.1 WD_REPEATS_REGION domain-containing protein [Caenorhabditis elegans]

Status: REVIEWED

UniProtKB/TrEMBL

D1MN68

Conserved Domains (2) summary

cd00200
Location:1 → 153

WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

sd00039
Location:1 → 36

7WD40; WD40 repeat [structural motif]
NM_001381616.2 → NP_001366714.1 Guanine nucleotide-binding protein subunit beta-1 [Caenorhabditis elegans]

Status: REVIEWED

UniProtKB/Swiss-Prot

P17343, Q19394, Q968T1

Conserved Domains (2) summary

cd00200
Location:48 → 340

WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

sd00039
Location:58 → 95

7WD40; WD40 repeat [structural motif]