vps-15 non-specific serine/threonine protein kinase [Caenorhabditis elegans] - Gene

Summary

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Official Symbol: vps-15
Official Full Name: non-specific serine/threonine protein kinase
Primary source: WormBase:WBGene00014151
Locus tag: CELE_ZK930.1
See related: AllianceGenome:WB:WBGene00014151
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Caenorhabditis elegans (strain: Bristol N2)
Lineage: Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary: Predicted to enable protein serine/threonine kinase activity. Predicted to be involved in late endosome to vacuole transport; pexophagy; and protein targeting to vacuole. Predicted to be part of phosphatidylinositol 3-kinase complex, class III, type I and phosphatidylinositol 3-kinase complex, class III, type II. Predicted to be active in late endosome and nucleus-vacuole junction. Orthologous to human PIK3R4 (phosphoinositide-3-kinase regulatory subunit 4). [provided by Alliance of Genome Resources, Dec 2024]
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Genomic context

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See vps-15 in Genome Data Viewer

Location:: chromosome: II

Exon count:: 14

Sequence:: Chromosome: II; NC_003280.10 (11908725..11915852, complement)

Chromosome II - NC_003280.10 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003280.10

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

ZK930.1 (e-PCR)
- UniSTS:310563

ZK930.7 (e-PCR)
- UniSTS:316357

Y17G7A.1 (e-PCR)
- UniSTS:308169

STS2-237 (e-PCR)
- UniSTS:241912

Homology

Orthologs from OrthoDB

Gene Ontology Provided by WormBase

Function	Evidence Code	Pubs
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables protein kinase activity	IEA Inferred from Electronic Annotation more info
enables protein serine/threonine kinase activity	IBA Inferred from Biological aspect of Ancestor more info
enables protein serine/threonine kinase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in late endosome to vacuole transport	IBA Inferred from Biological aspect of Ancestor more info
involved_in late endosome to vacuole transport	IEA Inferred from Electronic Annotation more info
involved_in macroautophagy	IEA Inferred from Electronic Annotation more info
involved_in pexophagy	IBA Inferred from Biological aspect of Ancestor more info
involved_in protein phosphorylation	IEA Inferred from Electronic Annotation more info
involved_in protein targeting to vacuole	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
is_active_in late endosome	IBA Inferred from Biological aspect of Ancestor more info
is_active_in nucleus-vacuole junction	IBA Inferred from Biological aspect of Ancestor more info
part_of phosphatidylinositol 3-kinase complex, class III, type I	IBA Inferred from Biological aspect of Ancestor more info
part_of phosphatidylinositol 3-kinase complex, class III, type II	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: non-specific serine/threonine protein kinase

NP_001254322.1

Confirmed by transcript evidence

NP_001254323.1

Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003280.10 Reference assembly

Range

11908725..11915852 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001267393.3 → NP_001254322.1 non-specific serine/threonine protein kinase [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_001254322.1

Status: REVIEWED

UniProtKB/TrEMBL

Q23669

Conserved Domains (6) summary

smart00320
Location:957 → 996

WD40; WD40 repeats

COG0515
Location:30 → 382

SPS1; Serine/threonine protein kinase [Signal transduction mechanisms]

COG2319
Location:948 → 1053

WD40; WD40 repeat [General function prediction only]

cd13980
Location:20 → 324

STKc_Vps15; Catalytic domain of the Serine/Threonine kinase, Vacuolar protein sorting-associated protein 15

sd00044
Location:540 → 565

HEAT; HEAT repeat [structural motif]

sd00039
Location:971 → 1017

7WD40; WD40 repeat [structural motif]
NM_001267394.3 → NP_001254323.1 non-specific serine/threonine protein kinase [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_001254323.1

Status: REVIEWED

UniProtKB/TrEMBL

E9P864

Conserved Domains (3) summary

smart00320
Location:48 → 87

WD40; WD40 repeats

COG2319
Location:39 → 144

WD40; WD40 repeat [General function prediction only]

sd00039
Location:62 → 108

7WD40; WD40 repeat [structural motif]