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mac-1 Protein mac-1 [ Caenorhabditis elegans ]

Gene ID: 174974, updated on 4-Jan-2025

Summary

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Official Symbol
mac-1
Official Full Name
Protein mac-1
Primary source
WormBase:WBGene00003119
Locus tag
CELE_Y48C3A.7
See related
AllianceGenome:WB:WBGene00003119
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Predicted to enable ATP hydrolysis activity and preribosome binding activity. Involved in lipid storage; negative regulation of apoptotic process; and positive regulation of nematode larval development. Predicted to be active in nucleus. Is expressed in intestine. Orthologous to human NVL (nuclear VCP like). [provided by Alliance of Genome Resources, Jan 2025]
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Genomic context

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See mac-1 in Genome Data Viewer
Location:
chromosome: II
Exon count:
7
Sequence:
Chromosome: II; NC_003280.10 (13311413..13320911, complement)

Chromosome II - NC_003280.10Genomic Context describing neighboring genes Neighboring gene Serine-rich adhesin for platelets;Uncharacterized protein;uncharacterized protein Neighboring gene ncRNA Neighboring gene C2H2-type domain-containing protein Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene Failed axon connections homolog Neighboring gene Single-stranded DNA-binding protein homolog sam-10 Neighboring gene ncRNA

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003280.10

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. C. elegans MAC-1, an essential member of the AAA family of ATPases, can bind CED-4 and prevent cell death. Wu D, et al. Development, 1999 May. PMID 10101135
  2. New insights into apoptosome structure and function. Dorstyn L, et al. Cell Death Differ, 2018 Jul. PMID 29765111, Free PMC Article
  3. C elegans: a model for exploring the genetics of fat storage. McKay RM, et al. Dev Cell, 2003 Jan. PMID 12530969, Free PMC Article
  4. A UPR-independent infection-specific role for a BiP/GRP78 protein in the control of antimicrobial peptide expression in C. elegans epidermis. Couillault C, et al. Virulence, 2012 May 1. PMID 22546897, Free PMC Article
  5. RNA targets and specificity of Staufen, a double-stranded RNA-binding protein in Caenorhabditis elegans. LeGendre JB, et al. J Biol Chem, 2013 Jan 25. PMID 23195953, Free PMC Article

See all (13) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables ATP hydrolysis activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables ATP hydrolysis activity IEA
Inferred from Electronic Annotation
more info
  
enables preribosome binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in apoptotic process IEA
Inferred from Electronic Annotation
more info
  
involved_in lipid storage IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in negative regulation of apoptotic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of nematode larval development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in ribosome biogenesis IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
Protein mac-1
NP_496814.1
  • Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003280.10 Reference assembly

    Range
    13311413..13320911 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_064413.9 → NP_496814.1  Protein mac-1 [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_496814.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q9NAG4, Q9U8K0
    Conserved Domains (2) summary
    pfam16725
    Location:5 → 65
    Nucleolin_bd; Nucleolin binding domain
    cl27568
    Location:191 → 804
    TIP49; TIP49 C-terminus
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9NAG4.2

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