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tbc-14 Rab-GAP TBC domain-containing protein [ Caenorhabditis elegans ]

Gene ID: 174986, updated on 2-Nov-2024

Summary

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Official Symbol
tbc-14
Official Full Name
Rab-GAP TBC domain-containing protein
Primary source
WormBase:WBGene00008444
Locus tag
CELE_E01G4.1
See related
AllianceGenome:WB:WBGene00008444
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Predicted to enable GTPase activator activity. Predicted to be located in cytoplasm. Orthologous to human TBC1D15 (TBC1 domain family member 15) and TBC1D17 (TBC1 domain family member 17). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See tbc-14 in Genome Data Viewer
Location:
chromosome: II
Exon count:
8
Sequence:
Chromosome: II; NC_003280.10 (13436923..13447593, complement)

Chromosome II - NC_003280.10Genomic Context describing neighboring genes Neighboring gene Carnosine N-methyltransferase Neighboring gene SnoaL-like domain-containing protein Neighboring gene ncRNA Neighboring gene MIF4G domain-containing protein;Prion-like-(Q/N-rich)-domain-bearing protein Neighboring gene Uncharacterized protein Neighboring gene ncRNA

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003280.10

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Antagonistic fungal enterotoxins intersect at multiple levels with host innate immune defences. Zhang X, et al. PLoS Genet, 2021 Jun. PMID 34166401, Free PMC Article
  2. Novel LOTUS-domain proteins are organizational hubs that recruit C. elegans Vasa to germ granules. Cipriani PG, et al. Elife, 2021 Jul 5. PMID 34223818, Free PMC Article
  3. EPIC: software toolkit for elution profile-based inference of protein complexes. Hu LZ, et al. Nat Methods, 2019 Aug. PMID 31308550, Free PMC Article
  4. OrthoList: a compendium of C. elegans genes with human orthologs. Shaye DD, et al. PLoS One, 2011. PMID 21647448, Free PMC Article
  5. OrthoList 2: A New Comparative Genomic Analysis of Human and Caenorhabditis elegans Genes. Kim W, et al. Genetics, 2018 Oct. PMID 30120140, Free PMC Article

See all (6) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
enables GTPase activator activity IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
Rab-GAP TBC domain-containing protein
NP_001317775.1
  • Confirmed by transcript evidence
NP_001317776.1
  • Partially confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003280.10 Reference assembly

    Range
    13436923..13447593 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001330963.2 → NP_001317775.1  Rab-GAP TBC domain-containing protein [Caenorhabditis elegans]

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A168H1X0
    Conserved Domains (2) summary
    smart00164
    Location:318 → 553
    TBC; Domain in Tre-2, BUB2p, and Cdc16p. Probable Rab-GAPs
    pfam12068
    Location:51 → 195
    DUF3548; Domain of unknown function (DUF3548)

  2. NM_001330964.4 → NP_001317776.1  Rab-GAP TBC domain-containing protein [Caenorhabditis elegans]

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A164D380
    Conserved Domains (2) summary
    smart00164
    Location:320 → 555
    TBC; Domain in Tre-2, BUB2p, and Cdc16p. Probable Rab-GAPs
    pfam12068
    Location:51 → 197
    DUF3548; Domain of unknown function (DUF3548)
Nucleotide Protein
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