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mcd-1 Modifier of cell death [ Caenorhabditis elegans ]

Gene ID: 175040, updated on 23-Jan-2025

Summary

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Official Symbol
mcd-1
Official Full Name
Modifier of cell death
Primary source
WormBase:WBGene00013096
Locus tag
CELE_Y51H1A.6
See related
AllianceGenome:WB:WBGene00013096
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Predicted to enable metal ion binding activity. Involved in nematode larval development; positive regulation of growth rate; and programmed cell death. [provided by Alliance of Genome Resources, Jan 2025]
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Genomic context

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See mcd-1 in Genome Data Viewer
Location:
chromosome: II
Exon count:
7
Sequence:
Chromosome: II; NC_003280.10 (13888544..13898463)

Chromosome II - NC_003280.10Genomic Context describing neighboring genes Neighboring gene Inhibitor of growth protein Neighboring gene Histone deacetylase domain-containing protein Neighboring gene Uncharacterized protein Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003280.10

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. The Caenorhabditis elegans ing-3 gene regulates ionizing radiation-induced germ-cell apoptosis in a p53-associated pathway. Luo J, et al. Genetics, 2009 Feb. PMID 19015549, Free PMC Article
  2. SUMOylation of the chromodomain factor MRG-1 in C. elegans affects chromatin-regulatory dynamics. Baytek G, et al. Biotechniques, 2022 Jun. PMID 35698829
  3. DPL-1 DP, LIN-35 Rb and EFL-1 E2F act with the MCD-1 zinc-finger protein to promote programmed cell death in Caenorhabditis elegans. Reddien PW, et al. Genetics, 2007 Apr. PMID 17237514, Free PMC Article
  4. Automated profiling of gene function during embryonic development. Green RA, et al. Cell, 2024 Jun 6. PMID 38759650,
  5. Large-scale RNAi screens identify novel genes that interact with the C. elegans retinoblastoma pathway as well as splicing-related components with synMuv B activity. Ceron J, et al. BMC Dev Biol, 2007 Apr 6. PMID 17417969, Free PMC Article

See all (8) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in apoptotic process IEA
Inferred from Electronic Annotation
more info
  
involved_in nematode larval development IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in positive regulation of growth rate IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in programmed cell death IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in programmed cell death IMP
Inferred from Mutant Phenotype
more info
 PubMed 

General protein information

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Preferred Names
Modifier of cell death
NP_001254412.1
  • Confirmed by transcript evidence
NP_001254413.1
  • Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003280.10 Reference assembly

    Range
    13888544..13898463
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001267483.3 → NP_001254412.1  Modifier of cell death [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_001254412.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    B7FAS0, B7FAS1

  2. NM_001267484.3 → NP_001254413.1  Modifier of cell death [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_001254413.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    B7FAS0
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
B7FAS0.1

Gene LinkOut

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