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lem-2 LEM protein 2 [ Caenorhabditis elegans ]

Gene ID: 175058, updated on 4-Jan-2025

Summary

Official Symbol
lem-2
Official Full Name
LEM protein 2
Primary source
WormBase:WBGene00002275
Locus tag
CELE_W01G7.5
See related
AllianceGenome:WB:WBGene00002275
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Enables chromatin DNA binding activity and lamin binding activity. Involved in several processes, including microtubule organizing center organization; nuclear membrane reassembly; and response to X-ray. Located in chromosome and nuclear envelope. Used to study Emery-Dreifuss muscular dystrophy and cataract 46 juvenile-onset. Human ortholog(s) of this gene implicated in Buschke-Ollendorff syndrome and cataract 46 juvenile-onset. Orthologous to human LEMD3 (LEM domain containing 3) and LEMD2 (LEM domain nuclear envelope protein 2). [provided by Alliance of Genome Resources, Jan 2025]
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Genomic context

See lem-2 in Genome Data Viewer
Location:
chromosome: II
Exon count:
3
Sequence:
Chromosome: II; NC_003280.10 (14063450..14066646)

Chromosome II - NC_003280.10Genomic Context describing neighboring genes Neighboring gene putative DNA-directed RNA polymerase II subunit RPB11 Neighboring gene putative RNA polymerase II nuclear localization protein SLC7A6OS Neighboring gene 5'-3' exoribonuclease 1 Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA

Bibliography

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
enables chromatin DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
 
enables chromatin DNA binding IDA
Inferred from Direct Assay
more info
PubMed 
enables lamin binding IDA
Inferred from Direct Assay
more info
PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
involved_in cell cycle IEA
Inferred from Electronic Annotation
more info
 
involved_in chromosome organization IDA
Inferred from Direct Assay
more info
PubMed 
involved_in chromosome organization IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in chromosome segregation IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in microtubule organizing center organization IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in mitotic cytokinesis IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in negative regulation of BMP signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in nuclear envelope organization IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in nuclear envelope organization IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in nuclear membrane reassembly IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in response to X-ray IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
located_in chromosome IDA
Inferred from Direct Assay
more info
PubMed 
located_in chromosome IEA
Inferred from Electronic Annotation
more info
 
located_in membrane IEA
Inferred from Electronic Annotation
more info
 
located_in nuclear envelope IDA
Inferred from Direct Assay
more info
PubMed 
located_in nuclear envelope IEA
Inferred from Electronic Annotation
more info
 
located_in nuclear inner membrane IEA
Inferred from Electronic Annotation
more info
 
located_in nucleus IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
LEM protein 2
NP_496944.1
  • Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003280.10 Reference assembly

    Range
    14063450..14066646
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_064543.3NP_496944.1  LEM protein 2 [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_496944.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q9XTB5
    Conserved Domains (2) summary
    cd12940
    Location:335
    LEM_LAP2_LEMD1; LEM (Lap2/Emerin/Man1) domain found in lamina-associated polypeptide 2 (LAP2), LEM domain-containing protein 1 (LEMP-1) and similar proteins
    pfam09402
    Location:384492
    MSC; Man1-Src1p-C-terminal domain