cacn-1 Splicing factor Cactin [Caenorhabditis elegans] - Gene

Summary

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Official Symbol: cacn-1
Official Full Name: Splicing factor Cactin
Primary source: WormBase:WBGene00012230
Locus tag: CELE_W03H9.4
See related: AllianceGenome:WB:WBGene00012230
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Caenorhabditis elegans (strain: Bristol N2)
Lineage: Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary: Predicted to enable RNA binding activity. Involved in several processes, including gonad development; positive regulation of cell migration; and regulation of Wnt signaling pathway. Located in cytoplasm and nucleus. Part of spliceosomal complex. Is expressed in several structures, including germ line; hermaphrodite gonad; hypodermal cell; intestine; and vulva. Orthologous to human CACTIN (cactin, spliceosome C complex subunit). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See cacn-1 in Genome Data Viewer

Location:: chromosome: II

Exon count:: 7

Sequence:: Chromosome: II; NC_003280.10 (14133320..14142148, complement)

Chromosome II - NC_003280.10 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003280.10

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

CACN-1 is needed in the soma for proper germ line development and maturation. When CACN-1 is depleted, sheath cells are absent and/or abnormal. CACN-1 is part of a protein network that influences somatic gonad development and function through alternative splicing or post-transcriptional gene regulation.
Title: CACN-1 is required in the Caenorhabditis elegans somatic gonad for proper oocyte development.
RNAi depletion experiments and analysis of the hypomorphic allele cacn-1 indicate that CACN-1 is required during distal tip cells migration for proper pathfinding and for cessation of distal tip cells migration at the end of larval morphogenesis.
Title: CACN-1/Cactin interacts genetically with MIG-2 GTPase signaling to control distal tip cell migration in C. elegans.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

K09E4.1 (e-PCR)
- UniSTS:307008

W03H9.3 (e-PCR)
- UniSTS:321142

W03H9.4 (e-PCR)
- UniSTS:319705

Homology

Orthologs from OrthoDB

Gene Ontology Provided by WormBase

Function	Evidence Code	Pubs
enables RNA binding	ISS Inferred from Sequence or Structural Similarity more info	PubMed

Process	Evidence Code	Pubs
involved_in gonad development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in mRNA cis splicing, via spliceosome	IBA Inferred from Biological aspect of Ancestor more info
involved_in mRNA splicing, via spliceosome	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of cell migration	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of Wnt signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of cell migration	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of gene expression	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasm	IDA Inferred from Direct Assay more info	PubMed
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed
located_in nucleus	IEA Inferred from Electronic Annotation more info
part_of spliceosomal complex	IBA Inferred from Biological aspect of Ancestor more info
part_of spliceosomal complex	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: Splicing factor Cactin

NP_001254420.1

Confirmed by transcript evidence

NP_001254421.1

Confirmed by transcript evidence

NP_001254422.1

Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003280.10 Reference assembly

Range

14133320..14142148 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001267493.4 → NP_001254422.1 Splicing factor Cactin [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_001254422.1

Status: REVIEWED

UniProtKB/Swiss-Prot

E5QCI6, E5QCI7, G5EG14

Conserved Domains (2) summary

pfam09732
Location:534 → 657

CactinC_cactus; Cactus-binding C-terminus of cactin protein

pfam10312
Location:175 → 345

Cactin_mid; Conserved mid region of cactin
NM_001267491.3 → NP_001254420.1 Splicing factor Cactin [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_001254420.1

Status: REVIEWED

UniProtKB/Swiss-Prot

G5EG14

Conserved Domains (1) summary

pfam09732
Location:222 → 345

CactinC_cactus; Cactus-binding C-terminus of cactin protein
NM_001267492.3 → NP_001254421.1 Splicing factor Cactin [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_001254421.1

Status: REVIEWED

UniProtKB/Swiss-Prot

G5EG14

Conserved Domains (1) summary

pfam09732
Location:73 → 196

CactinC_cactus; Cactus-binding C-terminus of cactin protein