U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

lin-7 Protein lin-7 homolog [ Caenorhabditis elegans ]

Gene ID: 175089, updated on 4-Jan-2025

Summary

Go to the top of the page Help
Official Symbol
lin-7
Official Full Name
Protein lin-7 homolog
Primary source
WormBase:WBGene00002996
Locus tag
CELE_Y54G11A.10
See related
AllianceGenome:WB:WBGene00002996
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Enables protein-macromolecule adaptor activity and signaling receptor binding activity. Involved in several processes, including egg-laying behavior; positive regulation of vulval development; and protein localization to basolateral plasma membrane. Located in cell-cell junction. Is expressed in several structures, including gonad; intestinal cell; somatic gonad precursor; somatic nervous system; and vulval precursor cell. Orthologous to human LIN7A (lin-7 homolog A, crumbs cell polarity complex component); LIN7B (lin-7 homolog B, crumbs cell polarity complex component); and LIN7C (lin-7 homolog C, crumbs cell polarity complex component). [provided by Alliance of Genome Resources, Jan 2025]
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
See lin-7 in Genome Data Viewer
Location:
chromosome: II
Exon count:
6
Sequence:
Chromosome: II; NC_003280.10 (14345844..14349406, complement)

Chromosome II - NC_003280.10Genomic Context describing neighboring genes Neighboring gene TPR_REGION domain-containing protein Neighboring gene FeS cluster biogenesis domain-containing protein Neighboring gene L51_S25_CI-B8 domain-containing protein Neighboring gene Transcription elongation factor 1 homolog Neighboring gene Glycogen debranching enzyme Neighboring gene pre-mRNA 3' end processing protein pfs-2

Genomic regions, transcripts, and products

Go to the top of the page Help
Genomic Sequence:
NC_003280.10

Go to nucleotide: Graphics FASTA GenBank

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. Localization of mLin-7 at nectin-based cell-cell junctions. Yamamoto Y, et al. Oncogene, 2002 Apr 11. PMID 11971189
  2. LIN-10 can promote LET-23 EGFR signaling and trafficking independently of LIN-2 and LIN-7. Gauthier KD, et al. Mol Biol Cell, 2021 Apr 15. PMID 33566630, Free PMC Article
  3. Golgi localization of the LIN-2/7/10 complex points to a role in basolateral secretion of LET-23 EGFR in the Caenorhabditiselegans vulval precursor cells. Gauthier KD, et al. Development, 2021 Mar 5. PMID 33526581, Free PMC Article
  4. The LIN-2/LIN-7/LIN-10 complex mediates basolateral membrane localization of the C. elegans EGF receptor LET-23 in vulval epithelial cells. Kaech SM, et al. Cell, 1998 Sep 18. PMID 9753323, Free PMC Article
  5. The tetrameric L27 domain complex as an organization platform for supramolecular assemblies. Feng W, et al. Nat Struct Mol Biol, 2004 May. PMID 15048107

See all (78) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

Go to the top of the page Help
Products Interactant Other Gene Complex Source Pubs Description

General gene information

Go to the top of the page Help

Markers

Homology

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables protein-macromolecule adaptor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables protein-macromolecule adaptor activity IPI
Inferred from Physical Interaction
more info
 PubMed 
enables signaling receptor binding IDA
Inferred from Direct Assay
more info
 PubMed 
Process Evidence Code Pubs
involved_in egg-laying behavior IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in epidermal growth factor receptor signaling pathway IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in exocytosis IEA
Inferred from Electronic Annotation
more info
  
involved_in neurotransmitter secretion IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in neurotransmitter secretion IEA
Inferred from Electronic Annotation
more info
  
involved_in positive regulation of vulval development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in post-embryonic development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in protein localization to basolateral plasma membrane IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in protein transport IEA
Inferred from Electronic Annotation
more info
  
involved_in regulation of synaptic assembly at neuromuscular junction IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in synaptic vesicle transport IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
part_of MPP7-DLG1-LIN7 complex IEA
Inferred from Electronic Annotation
more info
  
located_in anchoring junction IEA
Inferred from Electronic Annotation
more info
  
is_active_in basolateral plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in basolateral plasma membrane IEA
Inferred from Electronic Annotation
more info
  
located_in bicellular tight junction IEA
Inferred from Electronic Annotation
more info
  
located_in cell junction IEA
Inferred from Electronic Annotation
more info
  
is_active_in cell-cell junction IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cell-cell junction IDA
Inferred from Direct Assay
more info
 PubMed 
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
  
located_in presynapse IEA
Inferred from Electronic Annotation
more info
  
is_active_in synapse IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

Go to the top of the page Help
Preferred Names
Protein lin-7 homolog
NP_001122664.2
  • Confirmed by transcript evidence
NP_496982.2
  • Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003280.10 Reference assembly

    Range
    14345844..14349406 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001129192.6 → NP_001122664.2  Protein lin-7 homolog [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_001122664.2

    Status: REVIEWED

    UniProtKB/TrEMBL
    A5PEX5
    Conserved Domains (2) summary
    cd00992
    Location:90 → 171
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    pfam02828
    Location:13 → 63
    L27; L27 domain

  2. NM_064581.4 → NP_496982.2  Protein lin-7 homolog [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_496982.2

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q9U245
    Conserved Domains (2) summary
    cd00992
    Location:90 → 170
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    pfam02828
    Location:13 → 63
    L27; L27 domain
Nucleotide Protein
Heading Accession and Version

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.