U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

mes-2 Histone-lysine N-methyltransferase mes-2 [ Caenorhabditis elegans ]

Gene ID: 175096, updated on 2-Nov-2024

Summary

Go to the top of the page Help
Official Symbol
mes-2
Official Full Name
Histone-lysine N-methyltransferase mes-2
Primary source
WormBase:WBGene00003220
Locus tag
CELE_R06A4.7
See related
AllianceGenome:WB:WBGene00003220
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Enables histone H3K27 methyltransferase activity. Involved in epigenetic regulation of gene expression; germ-line stem cell division; and tissue development. Part of PcG protein complex and nucleosome. Is expressed in Z2; Z3; germ line; hypodermis; and intestine. Human ortholog(s) of this gene implicated in several diseases, including Weaver syndrome; gastrointestinal system cancer (multiple); glioblastoma; hematologic cancer (multiple); and renal Wilms' tumor. Orthologous to human EZH1 (enhancer of zeste 1 polycomb repressive complex 2 subunit) and EZH2 (enhancer of zeste 2 polycomb repressive complex 2 subunit). [provided by Alliance of Genome Resources, Nov 2024]
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
See mes-2 in Genome Data Viewer
Location:
chromosome: II
Exon count:
8
Sequence:
Chromosome: II; NC_003280.10 (14383973..14388454)

Chromosome II - NC_003280.10Genomic Context describing neighboring genes Neighboring gene Importin N-terminal domain-containing protein Neighboring gene AcetylCholine Receptor Neighboring gene SKN-1 Dependent Zygotic transcript Neighboring gene Secreted protein Neighboring gene Kinetochore-binding protein 3

Genomic regions, transcripts, and products

Go to the top of the page Help
Genomic Sequence:
NC_003280.10

Go to nucleotide: Graphics FASTA GenBank

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. Chromatin domains rich in inheritance. Reinberg D, et al. Science, 2018 Jul 6. PMID 29976815
  2. Differential localization and independent acquisition of the H3K9me2 and H3K9me3 chromatin modifications in the Caenorhabditis elegans adult germ line. Bessler JB, et al. PLoS Genet, 2010 Jan 22. PMID 20107519, Free PMC Article
  3. Interplay between histone deacetylase SIR-2, linker histone H1 and histone methyltransferases in heterochromatin formation. Wirth M, et al. Epigenetics, 2009 Aug 16. PMID 19736527
  4. Fine-tuning of chromatin composition and Polycomb recruitment by two Mi2 homologues during C. elegans early embryonic development. Käser-Pébernard S, et al. Epigenetics Chromatin, 2016. PMID 27651832, Free PMC Article
  5. The polycomb complex protein mes-2/E(z) promotes the transition from developmental plasticity to differentiation in C. elegans embryos. Yuzyuk T, et al. Dev Cell, 2009 May. PMID 19460346, Free PMC Article

See all (82) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. H3K27 modifiers regulate lifespan in C. elegans in a context-dependent manner.
    Title: H3K27 modifiers regulate lifespan in C. elegans in a context-dependent manner.
  2. mes-2 orchestrates large-scale changes in chromatin organization and gene expression to promote the timely loss of developmental plasticity.
    Title: The polycomb complex protein mes-2/E(z) promotes the transition from developmental plasticity to differentiation in C. elegans embryos.
  3. The SET domain of MES-2 functions as a histone h3 methyltransferase in X chromosome inactivation.
    Title: The MES-2/MES-3/MES-6 complex and regulation of histone H3 methylation in C. elegans.
  4. mes-2 represses Hox expression, causing anteroposterior transformations and disrupts Hox-dependent neuroblast migration.
    Title: Polycomb group regulation of Hox gene expression in C. elegans.
  5. mes-2 mutants suppress mab-3.
    Title: Finally, worm polycomb-like genes meet Hox regulation.
Submit: New GeneRIF Correction

Pathways from PubChem

Go to the top of the page

Interactions

Go to the top of the page Help
Products Interactant Other Gene Complex Source Pubs Description

General gene information

Go to the top of the page Help

Markers

Homology

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
enables chromatin binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables histone H3K27 methyltransferase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables histone H3K27 methyltransferase activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
enables histone H3K27 trimethyltransferase activity IEA
Inferred from Electronic Annotation
more info
  
enables histone methyltransferase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables histone methyltransferase activity IEA
Inferred from Electronic Annotation
more info
  
enables methyltransferase activity IEA
Inferred from Electronic Annotation
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in chromatin remodeling IEA
Inferred from Electronic Annotation
more info
  
involved_in epigenetic regulation of gene expression IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in gamete generation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in germ cell development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in germ-line stem cell division IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in heterochromatin formation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in methylation IEA
Inferred from Electronic Annotation
more info
  
involved_in regulation of gene expression IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in regulation of transcription by RNA polymerase II ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
involved_in tissue development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
part_of ESC/E(Z) complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of PcG protein complex IPI
Inferred from Physical Interaction
more info
 PubMed 
part_of nucleosome IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  

General protein information

Go to the top of the page Help
Preferred Names
Histone-lysine N-methyltransferase mes-2
NP_496992.3
  • Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003280.10 Reference assembly

    Range
    14383973..14388454
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_064591.7 → NP_496992.3  Histone-lysine N-methyltransferase mes-2 [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_496992.3

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    O17514, O62335
    Conserved Domains (2) summary
    smart00317
    Location:621 → 742
    SET; SET (Su(var)3-9, Enhancer-of-zeste, Trithorax) domain
    pfam13845
    Location:210 → 265
    Septum_form; Septum formation
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
O17514.2

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.