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glna-1 glutaminase [ Caenorhabditis elegans ]

Gene ID: 175130, updated on 4-Jan-2025

Summary

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Official Symbol
glna-1
Official Full Name
glutaminase
Primary source
WormBase:WBGene00007480
Locus tag
CELE_C09F9.3
See related
AllianceGenome:WB:WBGene00007480
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Predicted to enable glutaminase activity. Predicted to be involved in glutamate biosynthetic process and glutamine catabolic process. Predicted to be located in mitochondrion. Is expressed in several structures, including mc2; mc3DL; mc3DR; mc3V; and neurons. Human ortholog(s) of this gene implicated in developmental and epileptic encephalopathy 71. Orthologous to several human genes including GLS (glutaminase). [provided by Alliance of Genome Resources, Jan 2025]
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Genomic context

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See glna-1 in Genome Data Viewer
Location:
chromosome: II
Exon count:
14
Sequence:
Chromosome: II; NC_003280.10 (14720285..14733524, complement)

Chromosome II - NC_003280.10Genomic Context describing neighboring genes Neighboring gene pseudo Neighboring gene pseudo Neighboring gene ncRNA Neighboring gene G-protein coupled receptors family 1 profile domain-containing protein Neighboring gene Nonsense-mediated mRNA decay factor SMG9

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003280.10

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. A nuclear role for the respiratory enzyme CLK-1 in regulating mitochondrial stress responses and longevity. Monaghan RM, et al. Nat Cell Biol, 2015 Jun. PMID 25961505, Free PMC Article
  2. Cell-Specific mRNA Profiling of the Caenorhabditis elegans Somatic Gonadal Precursor Cells Identifies Suites of Sex-Biased and Gonad-Enriched Transcripts. Kroetz MB, et al. G3 (Bethesda), 2015 Oct 23. PMID 26497144, Free PMC Article
  3. Transcriptomics of ivermectin response in Caenorhabditis elegans: Integrating abamectin quantitative trait loci and comparison to the Ivermectin-exposed DA1316 strain. Dube F, et al. PLoS One, 2023. PMID 37141255, Free PMC Article
  4. Depletion of endogenously biotinylated carboxylases enhances the sensitivity of TurboID-mediated proximity labeling in Caenorhabditis elegans. Artan M, et al. J Biol Chem, 2022 Sep. PMID 35933017, Free PMC Article
  5. Interactome analysis of Caenorhabditis elegans synapses by TurboID-based proximity labeling. Artan M, et al. J Biol Chem, 2021 Sep. PMID 34416233, Free PMC Article

See all (8) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
enables glutaminase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables glutaminase activity IEA
Inferred from Electronic Annotation
more info
  
enables hydrolase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in glutamate biosynthetic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in glutamine catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in glutamine metabolic process IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in mitochondrion ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 

General protein information

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Preferred Names
glutaminase
NP_001254447.1
  • Confirmed by transcript evidence
NP_001254448.1
  • Confirmed by transcript evidence
NP_001293582.1
  • Confirmed by transcript evidence
NP_001367181.1
  • Confirmed by transcript evidence
NP_001368095.1
  • Confirmed by transcript evidence
NP_497054.2
  • Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003280.10 Reference assembly

    Range
    14720285..14733524 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001381664.2 → NP_001367181.1  glutaminase [Caenorhabditis elegans]

    Status: REVIEWED

    UniProtKB/TrEMBL
    B0M0P0
    Conserved Domains (4) summary
    sd00045
    Location:535 → 567
    ANK; ANK repeat [structural motif]
    pfam04960
    Location:185 → 476
    Glutaminase
    pfam12796
    Location:508 → 589
    Ank_2; Ankyrin repeats (3 copies)
    pfam17959
    Location:76 → 163
    EF-hand_14; EF-hand domain

  2. NM_001306653.1 → NP_001293582.1  glutaminase [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_001293582.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    U4PRW7
    Conserved Domains (4) summary
    sd00045
    Location:583 → 615
    ANK; ANK repeat [structural motif]
    pfam12796
    Location:556 → 637
    Ank_2; Ankyrin repeats (3 copies)
    pfam17959
    Location:124 → 211
    EF-hand_14; EF-hand domain
    pfam04960
    Location:233 → 526
    Glutaminase

  3. NM_001267518.5 → NP_001254447.1  glutaminase [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_001254447.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    B6VQ90
    Conserved Domains (4) summary
    sd00045
    Location:535 → 567
    ANK; ANK repeat [structural motif]
    pfam12796
    Location:508 → 589
    Ank_2; Ankyrin repeats (3 copies)
    pfam17959
    Location:76 → 163
    EF-hand_14; EF-hand domain
    pfam04960
    Location:185 → 478
    Glutaminase

  4. NM_001267519.3 → NP_001254448.1  glutaminase [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_001254448.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    H2L2H2
    Conserved Domains (4) summary
    sd00045
    Location:583 → 615
    ANK; ANK repeat [structural motif]
    pfam12796
    Location:556 → 637
    Ank_2; Ankyrin repeats (3 copies)
    pfam17959
    Location:124 → 211
    EF-hand_14; EF-hand domain
    pfam04960
    Location:233 → 526
    Glutaminase

  5. NM_001381663.1 → NP_001368095.1  glutaminase [Caenorhabditis elegans]

    Status: REVIEWED

    UniProtKB/TrEMBL
    H2L2H3
    Conserved Domains (4) summary
    sd00045
    Location:583 → 615
    ANK; ANK repeat [structural motif]
    pfam04960
    Location:233 → 524
    Glutaminase
    pfam12796
    Location:556 → 637
    Ank_2; Ankyrin repeats (3 copies)
    pfam17959
    Location:124 → 211
    EF-hand_14; EF-hand domain

  6. NM_064653.5 → NP_497054.2  glutaminase [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_497054.2

    Status: REVIEWED

    UniProtKB/TrEMBL
    B0M0N9
    Conserved Domains (4) summary
    sd00045
    Location:533 → 565
    ANK; ANK repeat [structural motif]
    pfam12796
    Location:506 → 587
    Ank_2; Ankyrin repeats (3 copies)
    pfam17959
    Location:76 → 163
    EF-hand_14; EF-hand domain
    pfam04960
    Location:185 → 476
    Glutaminase
Nucleotide Protein
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