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tac-1 Transforming acid coiled-coil-containing protein 1 [ Caenorhabditis elegans ]

Gene ID: 175133, updated on 4-Jan-2025

Summary

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Official Symbol
tac-1
Official Full Name
Transforming acid coiled-coil-containing protein 1
Primary source
WormBase:WBGene00006381
Locus tag
CELE_Y54E2A.3
See related
AllianceGenome:WB:WBGene00006381
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Enables protein domain specific binding activity. Involved in several processes, including pronuclear migration; regulation of microtubule polymerization or depolymerization; and spindle organization. Located in cytoplasm; kinetochore; and microtubule cytoskeleton. [provided by Alliance of Genome Resources, Jan 2025]
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Genomic context

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See tac-1 in Genome Data Viewer
Location:
chromosome: II
Exon count:
3
Sequence:
Chromosome: II; NC_003280.10 (14752891..14753877, complement)

Chromosome II - NC_003280.10Genomic Context describing neighboring genes Neighboring gene G-protein coupled receptors family 1 profile domain-containing protein Neighboring gene Nonsense-mediated mRNA decay factor SMG9 Neighboring gene Activating signal cointegrator 1 complex subunit 3;SEC63 domain-containing protein Neighboring gene Secreted protein Neighboring gene Uncharacterized protein

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003280.10

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Mos1-mediated transgenesis to probe consequences of single gene mutations in variation-rich isolates of Caenorhabditis elegans. Tarailo-Graovac M, et al. PLoS One, 2012. PMID 23155404, Free PMC Article
  2. The Caenorhabditis elegans Shugoshin regulates TAC-1 in cilia. Reed R, et al. Sci Rep, 2023 Jun 9. PMID 37296204, Free PMC Article
  3. ZYG-9ch-TOG promotes the stability of acentrosomal poles via regulation of spindle microtubules in C. elegans oocyte meiosis. Cavin-Meza G, et al. PLoS Genet, 2022 Nov. PMID 36449516, Free PMC Article
  4. ZYG-9, TAC-1 and ZYG-8 together ensure correct microtubule function throughout the cell cycle of C. elegans embryos. Bellanger JM, et al. J Cell Sci, 2007 Aug 15. PMID 17666432
  5. The arithmetic of centrosome biogenesis. Delattre M, et al. J Cell Sci, 2004 Apr 1. PMID 15075224

See all (34) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. The Caenorhabditis elegans Shugoshin regulates TAC-1 in cilia.
    Title: The Caenorhabditis elegans Shugoshin regulates TAC-1 in cilia.
  2. The EFA-6 N-terminus binds the microtubule-associated proteins TAC-1/Transforming-Acidic-Coiled-Coil, and ZYG-8/Doublecortin-Like-Kinase, both of which are required for regenerative growth cone formation, and which act downstream of EFA-6.
    Title: Axon injury triggers EFA-6 mediated destabilization of axonal microtubules via TACC and doublecortin like kinase.
  3. These findings indicate that ZYG-9-TAC-1 and ZYG-8 act in a partially redundant manner to ensure correct microtubule assembly throughout the cell cycle of early C. elegans embryos.
    Title: ZYG-9, TAC-1 and ZYG-8 together ensure correct microtubule function throughout the cell cycle of C. elegans embryos.
  4. ZYG-9 and TAC-1 physically interact in vivo, and this interaction is important for the efficient localization of the ZYG-9/TAC-1 complex to centrosomes
    Title: Caenorhabditis elegans TAC-1 and ZYG-9 form a complex that is essential for long astral and spindle microtubules.
  5. TAC-1 is a major regulator of microtubule length in the C. elegans embryo.
    Title: TAC-1, a regulator of microtubule length in the C. elegans embryo.
  6. mutual stabilization between TACC and XMAP215 proteins is a key feature ensuring microtubule assembly in vivo
    Title: TAC-1 and ZYG-9 form a complex that promotes microtubule assembly in C. elegans embryos.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables protein domain specific binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in astral microtubule organization IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in cell division IEA
Inferred from Electronic Annotation
more info
  
involved_in cell division IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in embryo development ending in birth or egg hatching IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in meiotic cell cycle IEA
Inferred from Electronic Annotation
more info
  
involved_in meiotic cell cycle IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in mitotic spindle elongation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in mitotic spindle organization IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in negative regulation of microtubule depolymerization IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in pronuclear migration IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in regulation of microtubule polymerization IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in axon IEA
Inferred from Electronic Annotation
more info
  
located_in cell projection IEA
Inferred from Electronic Annotation
more info
  
located_in centrosome IDA
Inferred from Direct Assay
more info
 PubMed 
located_in centrosome IEA
Inferred from Electronic Annotation
more info
  
located_in chromosome IEA
Inferred from Electronic Annotation
more info
  
located_in chromosome, centromeric region IEA
Inferred from Electronic Annotation
more info
  
located_in cytoplasm IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in cytoskeleton IEA
Inferred from Electronic Annotation
more info
  
located_in kinetochore IDA
Inferred from Direct Assay
more info
 PubMed 
located_in kinetochore IEA
Inferred from Electronic Annotation
more info
  
located_in microtubule IEA
Inferred from Electronic Annotation
more info
  
located_in perikaryon IEA
Inferred from Electronic Annotation
more info
  
located_in spindle IDA
Inferred from Direct Assay
more info
 PubMed 
located_in spindle pole IDA
Inferred from Direct Assay
more info
 PubMed 
located_in spindle pole IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
Transforming acid coiled-coil-containing protein 1
NP_497059.1
  • Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003280.10 Reference assembly

    Range
    14752891..14753877 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_064658.8 → NP_497059.1  Transforming acid coiled-coil-containing protein 1 [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_497059.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    G5ECG0
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
G5ECG0.1

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