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pole-4 Transcription factor CBF/NF-Y/archaeal histone domain-containing protein [ Caenorhabditis elegans ]

Gene ID: 175152, updated on 2-Nov-2024

Summary

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Official Symbol
pole-4
Official Full Name
Transcription factor CBF/NF-Y/archaeal histone domain-containing protein
Primary source
WormBase:WBGene00013150
Locus tag
CELE_Y53F4B.3
See related
AllianceGenome:WB:WBGene00013150
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Predicted to enable protein heterodimerization activity. Predicted to be involved in DNA-templated DNA replication. Predicted to be part of epsilon DNA polymerase complex. Predicted to be active in nucleus. Orthologous to human POLE4 (DNA polymerase epsilon 4, accessory subunit). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See pole-4 in Genome Data Viewer
Location:
chromosome: II
Exon count:
3
Sequence:
Chromosome: II; NC_003280.10 (14968633..14969354, complement)

Chromosome II - NC_003280.10Genomic Context describing neighboring genes Neighboring gene Protein kinase domain-containing protein Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene Elongation of very long chain fatty acids protein Neighboring gene 26S rRNA (cytosine-C(5))-methyltransferase nsun-5 Neighboring gene tRNA N(3)-methylcytidine methyltransferase Neighboring gene pseudo Neighboring gene ncRNA

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003280.10

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Synthetic Lethality between DNA Polymerase Epsilon and RTEL1 in Metazoan DNA Replication. Bellelli R, et al. Cell Rep, 2020 May 26. PMID 32460026, Free PMC Article
  2. C. elegans ISWI and NURF301 antagonize an Rb-like pathway in the determination of multiple cell fates. Andersen EC, et al. Development, 2006 Jul. PMID 16774993
  3. Extensive rewiring and complex evolutionary dynamics in a C. elegans multiparameter transcription factor network. Reece-Hoyes JS, et al. Mol Cell, 2013 Jul 11. PMID 23791784, Free PMC Article
  4. Transcriptional regulation. Okkema PG, et al. WormBook, 2005 Dec 23. PMID 18050428, Free PMC Article
  5. Empirically controlled mapping of the Caenorhabditis elegans protein-protein interactome network. Simonis N, et al. Nat Methods, 2009 Jan. PMID 19123269, Free PMC Article

See all (9) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables protein heterodimerization activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in DNA-templated DNA replication IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in positive regulation of transcription by RNA polymerase II IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
part_of epsilon DNA polymerase complex IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
Transcription factor CBF/NF-Y/archaeal histone domain-containing protein
NP_497087.1
  • Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003280.10 Reference assembly

    Range
    14968633..14969354 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_064686.5 → NP_497087.1  Transcription factor CBF/NF-Y/archaeal histone domain-containing protein [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_497087.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q9NAC5
    Conserved Domains (1) summary
    COG5208
    Location:13 → 121
    HAP5; CCAAT-binding factor, subunit C [Transcription]
Nucleotide Protein
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