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nsun-5 26S rRNA (cytosine-C(5))-methyltransferase nsun-5 [ Caenorhabditis elegans ]

Gene ID: 175153, updated on 2-Nov-2024

Summary

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Official Symbol
nsun-5
Official Full Name
26S rRNA (cytosine-C(5))-methyltransferase nsun-5
Primary source
WormBase:WBGene00013151
Locus tag
CELE_Y53F4B.4
See related
AllianceGenome:WB:WBGene00013151
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Enables rRNA (cytosine-C5-)-methyltransferase activity. Involved in several processes, including negative regulation of cellular response to heat; negative regulation of locomotion involved in locomotory behavior; and positive regulation of rRNA processing. Predicted to be active in nucleolus. Used to study Williams-Beuren syndrome. Orthologous to several human genes including NSUN5 (NOP2/Sun RNA methyltransferase 5). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See nsun-5 in Genome Data Viewer
Location:
chromosome: II
Exon count:
7
Sequence:
Chromosome: II; NC_003280.10 (14969617..14977005)

Chromosome II - NC_003280.10Genomic Context describing neighboring genes Neighboring gene Elongation of very long chain fatty acids protein Neighboring gene Transcription factor CBF/NF-Y/archaeal histone domain-containing protein Neighboring gene tRNA N(3)-methylcytidine methyltransferase Neighboring gene pseudo Neighboring gene ncRNA Neighboring gene C2H2-type domain-containing protein

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003280.10

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Corrigendum: Methylation of ribosomal RNA by NSUN5 is a conserved mechanism modulating organismal lifespan. Schosserer M, et al. Nat Commun, 2016 May 11. PMID 27167997, Free PMC Article
  2. A Novel Caenorhabditis Elegans Proteinopathy Model Shows Changes in mRNA Translational Frameshifting During Aging. Adamla F, et al. Cell Physiol Biochem, 2019. PMID 30977983, Free PMC Article
  3. The ribosomal RNA m(5)C methyltransferase NSUN-1 modulates healthspan and oogenesis in Caenorhabditis elegans. Heissenberger C, et al. Elife, 2020 Dec 8. PMID 33289480, Free PMC Article
  4. Translational adaptation to heat stress is mediated by RNA 5-methylcytosine in Caenorhabditis elegans. Navarro IC, et al. EMBO J, 2021 Mar 15. PMID 33283887, Free PMC Article
  5. Methylation of ribosomal RNA by NSUN5 is a conserved mechanism modulating organismal lifespan. Schosserer M, et al. Nat Commun, 2015 Jan 30. PMID 25635753, Free PMC Article

See all (10) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
enables RNA binding IEA
Inferred from Electronic Annotation
more info
  
enables RNA methyltransferase activity IEA
Inferred from Electronic Annotation
more info
  
enables methyltransferase activity IEA
Inferred from Electronic Annotation
more info
  
enables rRNA (cytosine-C5-)-methyltransferase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables rRNA (cytosine-C5-)-methyltransferase activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Process Evidence Code Pubs
involved_in RNA methylation IEA
Inferred from Electronic Annotation
more info
  
involved_in methylation IEA
Inferred from Electronic Annotation
more info
  
involved_in negative regulation of cellular response to heat IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in negative regulation of locomotion involved in locomotory behavior IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of rRNA processing IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in rRNA base methylation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in rRNA base methylation IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in rRNA processing IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
is_active_in nucleolus IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
26S rRNA (cytosine-C(5))-methyltransferase nsun-5
NP_001293548.1
  • Confirmed by transcript evidence
NP_001366973.1
  • Confirmed by transcript evidence
NP_001366974.1
  • Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003280.10 Reference assembly

    Range
    14969617..14977005
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001381672.1 → NP_001366973.1  26S rRNA (cytosine-C(5))-methyltransferase nsun-5 [Caenorhabditis elegans]

    Status: REVIEWED

    Conserved Domains (1) summary
    COG0144
    Location:61 → 282
    RsmB; 16S rRNA C967 or C1407 C5-methylase, RsmB/RsmF family [Translation, ribosomal structure and biogenesis]

  2. NM_001381671.1 → NP_001366974.1  26S rRNA (cytosine-C(5))-methyltransferase nsun-5 [Caenorhabditis elegans]

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q9NAA7, Q9NAA8, U4PB26
    Conserved Domains (1) summary
    COG0144
    Location:139 → 436
    RsmB; 16S rRNA C967 or C1407 C5-methylase, RsmB/RsmF family [Translation, ribosomal structure and biogenesis]

  3. NM_001306619.3 → NP_001293548.1  26S rRNA (cytosine-C(5))-methyltransferase nsun-5 [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_001293548.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    U4PB26
    Conserved Domains (1) summary
    COG0144
    Location:75 → 372
    RsmB; 16S rRNA C967 or C1407 C5-methylase, RsmB/RsmF family [Translation, ribosomal structure and biogenesis]
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9NAA7.2

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