pck-1 phosphoenolpyruvate carboxykinase (GTP) [Caenorhabditis elegans] - Gene

Summary

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Official Symbol: pck-1
Official Full Name: phosphoenolpyruvate carboxykinase (GTP)
Primary source: WormBase:WBGene00021043
Locus tag: CELE_W05G11.6
See related: AllianceGenome:WB:WBGene00021043
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Caenorhabditis elegans (strain: Bristol N2)
Lineage: Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary: Predicted to enable manganese ion binding activity and phosphoenolpyruvate carboxykinase (GTP) activity. Predicted to be involved in several processes, including carboxylic acid metabolic process; cellular response to glucose stimulus; and gluconeogenesis. Located in cytosol and striated muscle dense body. Is expressed in several structures, including body wall musculature; preanal ganglion; somatic nervous system; tail ganglion; and in male. Human ortholog(s) of this gene implicated in Alzheimer's disease and type 2 diabetes mellitus. Orthologous to several human genes including PCK1 (phosphoenolpyruvate carboxykinase 1). [provided by Alliance of Genome Resources, Jan 2025]
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Genomic context

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See pck-1 in Genome Data Viewer

Location:: chromosome: III

Exon count:: 5

Sequence:: Chromosome: III; NC_003281.10 (62888..66260, complement)

Chromosome III - NC_003281.10 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003281.10

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Data suggest, with age, metabolism exhibits reciprocal changes in PEPCK-C (down-regulation of cytosolic phosphoenolpyruvate carboxykinase) and PK (up-regulation of pyruvate kinase); metabolism shifts to glycolysis reducing mitochondrial bioenergetics.
Title: Reciprocal Changes in Phosphoenolpyruvate Carboxykinase and Pyruvate Kinase with Age Are a Determinant of Aging in Caenorhabditis elegans.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

W05G11.6 (e-PCR)
- UniSTS:306418

Homology

Orthologs from OrthoDB

Gene Ontology Provided by WormBase

Function	Evidence Code	Pubs
enables GTP binding	IEA Inferred from Electronic Annotation more info
enables carboxy-lyase activity	IEA Inferred from Electronic Annotation more info
enables manganese ion binding	IBA Inferred from Biological aspect of Ancestor more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables phosphoenolpyruvate carboxykinase (GTP) activity	IBA Inferred from Biological aspect of Ancestor more info
enables phosphoenolpyruvate carboxykinase (GTP) activity	IEA Inferred from Electronic Annotation more info
enables phosphoenolpyruvate carboxykinase activity	IEA Inferred from Electronic Annotation more info
enables purine nucleotide binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in cellular response to glucose stimulus	IBA Inferred from Biological aspect of Ancestor more info
involved_in gluconeogenesis	IBA Inferred from Biological aspect of Ancestor more info
involved_in gluconeogenesis	IEA Inferred from Electronic Annotation more info
involved_in glycerol biosynthetic process from pyruvate	IBA Inferred from Biological aspect of Ancestor more info
involved_in oxaloacetate metabolic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in propionate catabolic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in response to lipid	IBA Inferred from Biological aspect of Ancestor more info
involved_in response to starvation	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
located_in cytosol	HDA more info	PubMed
is_active_in cytosol	IBA Inferred from Biological aspect of Ancestor more info
located_in striated muscle dense body	HDA more info	PubMed

General protein information

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Preferred Names: phosphoenolpyruvate carboxykinase (GTP)

NP_497134.1

Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003281.10 Reference assembly

Range

62888..66260 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_064733.6 → NP_497134.1 phosphoenolpyruvate carboxykinase (GTP) [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_497134.1

Status: REVIEWED

UniProtKB/TrEMBL

O44906

Conserved Domains (1) summary

cd00819
Location:44 → 644

PEPCK_GTP; Phosphoenolpyruvate carboxykinase (PEPCK), a critical gluconeogenic enzyme, catalyzes the first committed step in the diversion of tricarboxylic acid cycle intermediates toward gluconeogenesis. It catalyzes the reversible decarboxylation and ...