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fem-2 Protein phosphatase fem-2 [ Caenorhabditis elegans ]

Gene ID: 175217, updated on 14-Nov-2024

Summary

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Official Symbol
fem-2
Official Full Name
Protein phosphatase fem-2
Primary source
WormBase:WBGene00001412
Locus tag
CELE_T19C3.8
See related
AllianceGenome:WB:WBGene00001412
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Enables calmodulin-dependent protein phosphatase activity. Involved in several processes, including masculinization of hermaphroditic germ-line; nematode male tail tip morphogenesis; and peptidyl-threonine dephosphorylation. Part of protein-containing complex. Orthologous to several human genes including PPM1F (protein phosphatase, Mg2+/Mn2+ dependent 1F). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See fem-2 in Genome Data Viewer
Location:
chromosome: III
Exon count:
5
Sequence:
Chromosome: III; NC_003281.10 (632019..634626, complement)

Chromosome III - NC_003281.10Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene Uncharacterized protein Neighboring gene Uncharacterized protein Neighboring gene Uncharacterized protein Neighboring gene Ribosome maturation protein SBDS

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003281.10

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. The C. elegans sex-determining gene fem-2 encodes a putative protein phosphatase. Pilgrim D, et al. Mol Biol Cell, 1995 Sep. PMID 8534913, Free PMC Article
  2. Parental DNA strands segregate randomly during embryonic development of Caenorhabditis elegans. Ito K, et al. Cell, 1987 May 8. PMID 3568128
  3. Molecular evolution of a sex determination protein. FEM-2 (pp2c) in Caenorhabditis. Hansen D, et al. Genetics, 1998 Jul. PMID 9649525, Free PMC Article
  4. Conspecific and interspecific interactions between the FEM-2 and the FEM-3 sex-determining proteins despite rapid sequence divergence. Stothard P, et al. J Mol Evol, 2006 Mar. PMID 16477523
  5. CeRep25B forms chromosome-specific minisatellite arrays in Caenorhabditis elegans. Pilgrim D. Genome Res, 1998 Nov. PMID 9847081, Free PMC Article

See all (116) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
enables calmodulin-dependent protein phosphatase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables myosin phosphatase activity IEA
Inferred from Electronic Annotation
more info
  
enables phosphoprotein phosphatase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables phosphoprotein phosphatase activity IEA
Inferred from Electronic Annotation
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables protein serine/threonine phosphatase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables protein serine/threonine phosphatase activity IEA
Inferred from Electronic Annotation
more info
  
enables protein serine/threonine phosphatase activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Process Evidence Code Pubs
involved_in apoptotic process IEA
Inferred from Electronic Annotation
more info
  
involved_in cell differentiation IEA
Inferred from Electronic Annotation
more info
  
involved_in male sex determination IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in masculinization of hermaphroditic germ-line IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in nematode male tail tip morphogenesis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in peptidyl-threonine dephosphorylation IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in peptidyl-threonine dephosphorylation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of cysteine-type endopeptidase activity IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in protein dephosphorylation IEA
Inferred from Electronic Annotation
more info
  
involved_in sex differentiation IEA
Inferred from Electronic Annotation
more info
  
involved_in signal transduction IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
part_of protein-containing complex IMP
Inferred from Mutant Phenotype
more info
 PubMed 

General protein information

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Preferred Names
Protein phosphatase fem-2
NP_497224.1
  • Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003281.10 Reference assembly

    Range
    632019..634626 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_064823.10 → NP_497224.1  Protein phosphatase fem-2 [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_497224.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    P49594
    Conserved Domains (1) summary
    pfam00481
    Location:161 → 417
    PP2C; Protein phosphatase 2C
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P49594.2

Gene LinkOut

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