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cisd-3.2 Iron-binding zinc finger CDGSH type domain-containing protein [ Caenorhabditis elegans ]

Gene ID: 175307, updated on 4-Jan-2025

Summary

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Official Symbol
cisd-3.2
Official Full Name
Iron-binding zinc finger CDGSH type domain-containing protein
Primary source
WormBase:WBGene00022053
Locus tag
CELE_Y67D2.3
See related
AllianceGenome:WB:WBGene00022053
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Predicted to enable 2 iron, 2 sulfur cluster binding activity. Predicted to be involved in protein maturation by [2Fe-2S] cluster transfer. Predicted to be located in cytoplasm and intracellular membrane-bounded organelle. Predicted to be active in mitochondrion. Orthologous to human CISD3 (CDGSH iron sulfur domain 3). [provided by Alliance of Genome Resources, Jan 2025]
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Genomic context

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See cisd-3.2 in Genome Data Viewer
Location:
chromosome: III
Exon count:
4
Sequence:
Chromosome: III; NC_003281.10 (1540493..1543448)

Chromosome III - NC_003281.10Genomic Context describing neighboring genes Neighboring gene CP-type G domain-containing protein;Mitochondrial GTPase 1 Neighboring gene ncRNA Neighboring gene N-acetyltransferase 9-like protein Neighboring gene putative ATP-dependent RNA helicase DHX35 homolog Neighboring gene ncRNA Neighboring gene Early ELOngation arrest Neighboring gene ncRNA

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003281.10

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. The mitochondrial localized CISD-3.1/CISD-3.2 proteins are required to maintain normal germline structure and function in Caenorhabditis elegans. King SD, et al. PLoS One, 2021. PMID 33544710, Free PMC Article
  2. Structure and biological evaluation of Caenorhabditis elegans CISD-1/mitoNEET, a KLP-17 tail domain homologue, supports attenuation of paraquat-induced oxidative stress through a p38 MAPK-mediated antioxidant defense response. Boos JR, et al. Adv Redox Res, 2022 Dec. PMID 36533211, Free PMC Article
  3. The cisd gene family regulates physiological germline apoptosis through ced-13 and the canonical cell death pathway in Caenorhabditis elegans. King SD, et al. Cell Death Differ, 2019 Jan. PMID 29666474, Free PMC Article
  4. Novel LOTUS-domain proteins are organizational hubs that recruit C. elegans Vasa to germ granules. Cipriani PG, et al. Elife, 2021 Jul 5. PMID 34223818, Free PMC Article
  5. EPIC: software toolkit for elution profile-based inference of protein complexes. Hu LZ, et al. Nat Methods, 2019 Aug. PMID 31308550, Free PMC Article

See all (8) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
enables 2 iron, 2 sulfur cluster binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables 2 iron, 2 sulfur cluster binding IEA
Inferred from Electronic Annotation
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in protein maturation by [2Fe-2S] cluster transfer IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in intracellular membrane-bounded organelle IEA
Inferred from Electronic Annotation
more info
  
is_active_in mitochondrion IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
Iron-binding zinc finger CDGSH type domain-containing protein
NP_497419.1
  • Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003281.10 Reference assembly

    Range
    1540493..1543448
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_065018.9 → NP_497419.1  Iron-binding zinc finger CDGSH type domain-containing protein [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_497419.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q9BKQ9
    Conserved Domains (1) summary
    cl02748
    Location:48 → 81
    zf-CDGSH; Iron-binding zinc finger CDGSH type
Nucleotide Protein
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