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Y71H2AM.11 Peptidase M20 dimerization domain-containing protein [ Caenorhabditis elegans ]

Gene ID: 175387, updated on 4-Jan-2025

Summary

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Official Symbol
Y71H2AM.11
Official Full Name
Peptidase M20 dimerization domain-containing protein
Primary source
WormBase:WBGene00022176
Locus tag
CELE_Y71H2AM.11
See related
AllianceGenome:WB:WBGene00022176
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Predicted to enable peptidase activity. Predicted to be involved in proteolysis. Human ortholog(s) of this gene implicated in glomerulonephritis. Orthologous to several human genes including CNDP2 (carnosine dipeptidase 2). [provided by Alliance of Genome Resources, Jan 2025]
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Genomic context

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See Y71H2AM.11 in Genome Data Viewer
Location:
chromosome: III
Exon count:
7
Sequence:
Chromosome: III; NC_003281.10 (2718230..2725092, complement)

Chromosome III - NC_003281.10Genomic Context describing neighboring genes Neighboring gene protein-histidine N-methyltransferase Neighboring gene Transmembrane protein 132 homolog Neighboring gene tRNA-Pro Neighboring gene Cyclin N-terminal domain-containing protein Neighboring gene Ras-related protein Rab-18 Neighboring gene Carboxylesterase type B domain-containing protein

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003281.10

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Depletion of endogenously biotinylated carboxylases enhances the sensitivity of TurboID-mediated proximity labeling in Caenorhabditis elegans. Artan M, et al. J Biol Chem, 2022 Sep. PMID 35933017, Free PMC Article
  2. Interactome analysis of Caenorhabditis elegans synapses by TurboID-based proximity labeling. Artan M, et al. J Biol Chem, 2021 Sep. PMID 34416233, Free PMC Article
  3. Novel LOTUS-domain proteins are organizational hubs that recruit C. elegans Vasa to germ granules. Cipriani PG, et al. Elife, 2021 Jul 5. PMID 34223818, Free PMC Article
  4. EPIC: software toolkit for elution profile-based inference of protein complexes. Hu LZ, et al. Nat Methods, 2019 Aug. PMID 31308550, Free PMC Article
  5. Genome sequence of the nematode C. elegans: a platform for investigating biology. C. elegans Sequencing Consortium. Science, 1998 Dec 11. PMID 9851916

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
enables hydrolase activity IEA
Inferred from Electronic Annotation
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables metallodipeptidase activity IEA
Inferred from Electronic Annotation
more info
  
enables peptidase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in proteolysis IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
Peptidase M20 dimerization domain-containing protein
NP_497606.4
  • Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003281.10 Reference assembly

    Range
    2718230..2725092 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_065205.8 → NP_497606.4  Peptidase M20 dimerization domain-containing protein [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_497606.4

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q9BL46
    Conserved Domains (1) summary
    cd05676
    Location:7 → 472
    M20_dipept_like_CNDP; M20 cytosolic nonspecific dipeptidases including anserinase and serum carnosinase
Nucleotide Protein
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