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spe-41 Transient receptor ion channel domain-containing protein [ Caenorhabditis elegans ]

Gene ID: 175446, updated on 9-Dec-2024

Summary

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Official Symbol
spe-41
Official Full Name
Transient receptor ion channel domain-containing protein
Primary source
WormBase:WBGene00004976
Locus tag
CELE_K01A11.4
See related
AllianceGenome:WB:WBGene00004976
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Enables store-operated calcium channel activity. Involved in calcium ion transport; intracellular calcium ion homeostasis; and single fertilization. Located in cytoplasmic vesicle and pseudopodium membrane. Is expressed in sperm and spermatid. [provided by Alliance of Genome Resources, Dec 2024]
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Genomic context

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See spe-41 in Genome Data Viewer
Location:
chromosome: III
Exon count:
15
Sequence:
Chromosome: III; NC_003281.10 (3439011..3444210, complement)

Chromosome III - NC_003281.10Genomic Context describing neighboring genes Neighboring gene protein-histidine N-methyltransferase Neighboring gene Spaetzle domain-containing protein Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene USP domain-containing protein Neighboring gene Transposase Neighboring gene Fibronectin type-III domain-containing protein

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003281.10

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Fertility and TRP Channels. Emir TLR, et al. , 2017. PMID 29356480
  2. The Sperm TRP-3 Channel Mediates the Onset of a Ca(2+) Wave in the Fertilized C. elegans Oocyte. Takayama J, et al. Cell Rep, 2016 Apr 19. PMID 27068469
  3. The sperm surface localization of the TRP-3/SPE-41 Ca2+ -permeable channel depends on SPE-38 function in Caenorhabditis elegans. Singaravelu G, et al. Dev Biol, 2012 May 15. PMID 22425620, Free PMC Article
  4. The Caenorhabditis elegans spe-38 gene encodes a novel four-pass integral membrane protein required for sperm function at fertilization. Chatterjee I, et al. Development, 2005 Jun. PMID 15930110
  5. A C. elegans sperm TRP protein required for sperm-egg interactions during fertilization. Xu XZ, et al. Cell, 2003 Aug 8. PMID 12914694

See all (18) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
enables calcium channel activity IEA
Inferred from Electronic Annotation
more info
  
enables inositol 1,4,5 trisphosphate binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables store-operated calcium channel activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables store-operated calcium channel activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables store-operated calcium channel activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Process Evidence Code Pubs
involved_in calcium ion transmembrane transport IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in calcium ion transmembrane transport IEA
Inferred from Electronic Annotation
more info
  
involved_in calcium ion transport IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in calcium ion transport IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in intracellular calcium ion homeostasis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in regulation of cytosolic calcium ion concentration IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in single fertilization IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in single fertilization IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
part_of cation channel complex IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytoplasmic vesicle IDA
Inferred from Direct Assay
more info
 PubMed 
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in plasma membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in pseudopodium membrane IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
Transient receptor ion channel domain-containing protein
NP_001254872.1
  • Confirmed by transcript evidence
NP_001379535.1
  • Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003281.10 Reference assembly

    Range
    3439011..3444210 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001267943.4 → NP_001254872.1  Transient receptor ion channel domain-containing protein [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_001254872.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    G5EF09
    Conserved Domains (1) summary
    TIGR00870
    Location:87 → 671
    trp; transient-receptor-potential calcium channel protein

  2. NM_001393307.1 → NP_001379535.1  Transient receptor ion channel domain-containing protein [Caenorhabditis elegans]

    Status: REVIEWED

    UniProtKB/TrEMBL
    G3MTY7
    Conserved Domains (1) summary
    TIGR00870
    Location:2 → 528
    trp; transient-receptor-potential calcium channel protein
Nucleotide Protein
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