npr-15 Neuropeptide receptor 15 [Caenorhabditis elegans] - Gene

Summary

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Official Symbol: npr-15
Official Full Name: Neuropeptide receptor 15
Primary source: WormBase:WBGene00012084
Locus tag: CELE_T27D1.3
See related: AllianceGenome:WB:WBGene00012084
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Caenorhabditis elegans (strain: Bristol N2)
Lineage: Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary: Predicted to enable G protein-coupled receptor activity. Predicted to be involved in G protein-coupled receptor signaling pathway. Predicted to be located in plasma membrane. Is expressed in amphid neurons; head neurons; and pharyngeal muscle cell. Human ortholog(s) of this gene implicated in several diseases, including artery disease (multiple); chronic kidney disease (multiple); glomerulonephritis (multiple); lung disease (multiple); and neurodegenerative disease (multiple). Orthologous to several human genes including GPR15 (G protein-coupled receptor 15); GPR25 (G protein-coupled receptor 25); and AGTR1 (angiotensin II receptor type 1). [provided by Alliance of Genome Resources, Dec 2024]
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Genomic context

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See npr-15 in Genome Data Viewer

Location:: chromosome: III

Exon count:: 7

Sequence:: Chromosome: III; NC_003281.10 (3683253..3685808, complement)

Chromosome III - NC_003281.10 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003281.10

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Neuronal NPR-15 modulates molecular and behavioral immune responses via the amphid sensory neuron-intestinal axis in C. elegans.
Title: Neuronal NPR-15 modulates molecular and behavioral immune responses via the amphid sensory neuron-intestinal axis in C. elegans.
The G protein-coupled receptor neuropeptide receptor-15 modulates larval development via the transforming growth factor-beta DAF-7 protein in Caenorhabditis elegans.
Title: The G protein-coupled receptor neuropeptide receptor-15 modulates larval development via the transforming growth factor-β DAF-7 protein in Caenorhabditis elegans.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

T27D1.3 (e-PCR)
- UniSTS:315117

Homology

Orthologs from OrthoDB

Gene Ontology Provided by WormBase

Function	Evidence Code	Pubs
enables G protein-coupled receptor activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in G protein-coupled receptor signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in G protein-coupled receptor signaling pathway	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in membrane	IEA Inferred from Electronic Annotation more info
located_in plasma membrane	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: Neuropeptide receptor 15

NP_001382691.1

Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003281.10 Reference assembly

Range

3683253..3685808 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001395820.1 → NP_001382691.1 Neuropeptide receptor 15 [Caenorhabditis elegans]

Status: REVIEWED

UniProtKB/Swiss-Prot

O01344, Q09638

Conserved Domains (2) summary

cd14964
Location:9 → 33

7tm_GPCRs; TM helix 1 [structural motif]

cl28897
Location:9 → 296

7tm_GPCRs; seven-transmembrane G protein-coupled receptor superfamily