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nrde-1 Dynein regulatory complex subunit 7;SWIM-type domain-containing protein [ Caenorhabditis elegans ]

Gene ID: 175477, updated on 2-Nov-2024

Summary

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Official Symbol
nrde-1
Official Full Name
Dynein regulatory complex subunit 7;SWIM-type domain-containing protein
Primary source
WormBase:WBGene00007577
Locus tag
CELE_C14B1.6
See related
AllianceGenome:WB:WBGene00007577
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Involved in regulatory ncRNA-mediated post-transcriptional gene silencing. Located in nucleus. [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See nrde-1 in Genome Data Viewer
Location:
chromosome: III
Exon count:
15
Sequence:
Chromosome: III; NC_003281.10 (3713463..3718750)

Chromosome III - NC_003281.10Genomic Context describing neighboring genes Neighboring gene 2-(3-amino-3-carboxypropyl)histidine synthase subunit 1 Neighboring gene Fe2OG dioxygenase domain-containing protein Neighboring gene FGFR1 oncogene partner 2 homolog Neighboring gene pseudo Neighboring gene Spliceosome-associated protein CWC15 homolog

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003281.10

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. lin-4 and the NRDE pathway are required to activate a transgenic lin-4 reporter but not the endogenous lin-4 locus in C. elegans. Jiao AL, et al. PLoS One, 2018. PMID 29324872, Free PMC Article
  2. Small RNAs, RNAi and the inheritance of gene silencing in Caenorhabditis elegans. Feng X, et al. J Genet Genomics, 2013 Apr 20. PMID 23618398
  3. Nuclear RNAi maintains heritable gene silencing in Caenorhabditis elegans. Burton NO, et al. Proc Natl Acad Sci U S A, 2011 Dec 6. PMID 22106253, Free PMC Article
  4. A nuclear Argonaute promotes multigenerational epigenetic inheritance and germline immortality. Buckley BA, et al. Nature, 2012 Sep 20. PMID 22810588, Free PMC Article
  5. A pre-mRNA-associating factor links endogenous siRNAs to chromatin regulation. Burkhart KB, et al. PLoS Genet, 2011 Aug. PMID 21901112, Free PMC Article

See all (14) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. NRDE-1 is a novel pre-mRNA and chromatin-associating factor that links small RNAs to H3K9 methylation.
    Title: A pre-mRNA-associating factor links endogenous siRNAs to chromatin regulation.
  2. Studies indicate that the heritable silencing pathway depends on at least four genes, designated as nuclear RNAi defective 1-4 (nrde-1/2/3/4).
    Title: Small RNAs, RNAi and the inheritance of gene silencing in Caenorhabditis elegans.
Submit: New GeneRIF Correction

General gene information

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Markers

Homology

Gene Ontology Provided by WormBase

Process Evidence Code Pubs
involved_in regulatory ncRNA-mediated post-transcriptional gene silencing IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in nucleus IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
Dynein regulatory complex subunit 7;SWIM-type domain-containing protein
NP_001348738.1
  • Partially confirmed by transcript evidence
NP_497752.2
  • Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003281.10 Reference assembly

    Range
    3713463..3718750
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_065351.8 → NP_497752.2  Dynein regulatory complex subunit 7 [Caenorhabditis elegans]

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q17968

  2. NM_001361894.4 → NP_001348738.1  SWIM-type domain-containing protein [Caenorhabditis elegans]

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A2K5ATT7
Nucleotide Protein
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