dcn-1 Defective in cullin neddylation protein 1 [Caenorhabditis elegans] - Gene

Summary

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Official Symbol: dcn-1
Official Full Name: Defective in cullin neddylation protein 1
Primary source: WormBase:WBGene00010428
Locus tag: CELE_H38K22.2
See related: AllianceGenome:WB:WBGene00010428
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Caenorhabditis elegans (strain: Bristol N2)
Lineage: Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary: Enables ubiquitin binding activity. Involved in microtubule cytoskeleton organization; protein catabolic process; and protein neddylation. Located in cytoplasm and nucleus. Orthologous to human DCUN1D1 (defective in cullin neddylation 1 domain containing 1) and DCUN1D2 (defective in cullin neddylation 1 domain containing 2). [provided by Alliance of Genome Resources, Jan 2025]
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Genomic context

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See dcn-1 in Genome Data Viewer

Location:: chromosome: III

Exon count:: 5

Sequence:: Chromosome: III; NC_003281.10 (4313925..4317608)

Chromosome III - NC_003281.10 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003281.10

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

DCN-1 directly bind Nedd8 and physically associate with cullins
Title: The conserved protein DCN-1/Dcn1p is required for cullin neddylation in C. elegans and S. cerevisiae.

Submit: New GeneRIF Correction

Pathways from PubChem

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

H38K22.2 (e-PCR)
- UniSTS:319464

Homology

Orthologs from OrthoDB

Gene Ontology Provided by WormBase

Function	Evidence Code	Pubs
enables cullin family protein binding	IBA Inferred from Biological aspect of Ancestor more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables ubiquitin binding	IDA Inferred from Direct Assay more info	PubMed
enables ubiquitin conjugating enzyme binding	IBA Inferred from Biological aspect of Ancestor more info
enables ubiquitin-like protein binding	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in astral microtubule organization	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in establishment of mitotic spindle localization	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in protein catabolic process	IGI Inferred from Genetic Interaction more info	PubMed
involved_in protein catabolic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in protein neddylation	IBA Inferred from Biological aspect of Ancestor more info
involved_in protein neddylation	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in cytoplasm	IDA Inferred from Direct Assay more info	PubMed
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed
located_in nucleus	IEA Inferred from Electronic Annotation more info
part_of ubiquitin ligase complex	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: Defective in cullin neddylation protein 1

NP_001379250.1

Confirmed by transcript evidence

NP_497866.2

Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003281.10 Reference assembly

Range

4313925..4317608

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001393320.1 → NP_001379250.1 Defective in cullin neddylation protein 1 [Caenorhabditis elegans]

Status: REVIEWED

Conserved Domains (1) summary

pfam03556
Location:87 → 217

Cullin_binding; Cullin binding
NM_065465.6 → NP_497866.2 Defective in cullin neddylation protein 1 [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_497866.2

Status: REVIEWED

UniProtKB/Swiss-Prot

Q9U3C8, Q9U3C9

Conserved Domains (2) summary

cd14350
Location:7 → 48

UBA_DCNL; UBA-like domain found in DCN1-like protein DCNL1, DCNL2 and similar proteins

pfam03556
Location:140 → 271

Cullin_binding; Cullin binding