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cdk-12 Cyclin-dependent kinase 12 [ Caenorhabditis elegans ]

Gene ID: 175559, updated on 4-Jan-2025

Summary

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Official Symbol
cdk-12
Official Full Name
Cyclin-dependent kinase 12
Primary source
WormBase:WBGene00007135
Locus tag
CELE_B0285.1
See related
AllianceGenome:WB:WBGene00007135
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Predicted to enable RNA polymerase II CTD heptapeptide repeat kinase activity and cyclin binding activity. Involved in nematode larval development. Located in euchromatin. Is expressed in several structures, including arcade cell; germ line; head; intestine; and rectal gland cell. Human ortholog(s) of this gene implicated in congenital heart defects, dysmorphic facial features, and intellectual developmental disorder; hepatocellular carcinoma; intellectual disability; and prostate carcinoma. Orthologous to several human genes including CDK13 (cyclin dependent kinase 13). [provided by Alliance of Genome Resources, Jan 2025]
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Genomic context

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See cdk-12 in Genome Data Viewer
Location:
chromosome: III
Exon count:
15
Sequence:
Chromosome: III; NC_003281.10 (4332992..4341984)

Chromosome III - NC_003281.10Genomic Context describing neighboring genes Neighboring gene TMhelix containing protein Neighboring gene Ricin B lectin domain-containing protein;putative N-acetylgalactosaminyltransferase 6 Neighboring gene ncRNA Neighboring gene Uncharacterized protein Neighboring gene Leucine carboxyl methyltransferase 1 Neighboring gene D-glucuronyl C5-epimerase

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003281.10

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. The Caenorhabditis elegans gene ncc-1 encodes a cdc2-related kinase required for M phase in meiotic and mitotic cell divisions, but not for S phase. Boxem M, et al. Development, 1999 May. PMID 10207147
  2. RNA polymerase II CTD S2P is dispensable for embryogenesis but mediates exit from developmental diapause in C. elegans. Cassart C, et al. Sci Adv, 2020 Dec. PMID 33298437, Free PMC Article
  3. Phosphorylation of RNA polymerase II is independent of P-TEFb in the C. elegans germline. Bowman EA, et al. Development, 2013 Sep. PMID 23903194, Free PMC Article
  4. A whole-genome RNAi Screen for C. elegans miRNA pathway genes. Parry DH, et al. Curr Biol, 2007 Dec 4. PMID 18023351, Free PMC Article
  5. Multiple ERK substrates execute single biological processes in Caenorhabditis elegans germ-line development. Arur S, et al. Proc Natl Acad Sci U S A, 2009 Mar 24. PMID 19264959, Free PMC Article

See all (13) citations in PubMed

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables RNA polymerase II CTD heptapeptide repeat kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables RNA polymerase II CTD heptapeptide repeat kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables cyclin binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables cyclin-dependent protein serine/threonine kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables protein kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables protein serine kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables protein serine/threonine kinase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in nematode larval development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of transcription elongation by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in protein phosphorylation IEA
Inferred from Electronic Annotation
more info
  
involved_in regulation of cell cycle IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
part_of cyclin/CDK positive transcription elongation factor complex IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in euchromatin IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
Cyclin-dependent kinase 12
NP_001254916.1
  • Partially confirmed by transcript evidence
NP_001367220.1
  • Confirmed by transcript evidence
NP_001367221.1
  • Partially confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003281.10 Reference assembly

    Range
    4332992..4341984
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001381836.2 → NP_001367220.1  Cyclin-dependent kinase 12 [Caenorhabditis elegans]

    Status: REVIEWED

    Conserved Domains (1) summary
    cd07864
    Location:303 → 605
    STKc_CDK12; Catalytic domain of the Serine/Threonine Kinase, Cyclin-Dependent protein Kinase 12

  2. NM_001381837.2 → NP_001367221.1  Cyclin-dependent kinase 12 [Caenorhabditis elegans]

    Status: REVIEWED

    Conserved Domains (1) summary
    cd07864
    Location:303 → 605
    STKc_CDK12; Catalytic domain of the Serine/Threonine Kinase, Cyclin-Dependent protein Kinase 12

  3. NM_001267987.3 → NP_001254916.1  Cyclin-dependent kinase 12 [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_001254916.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    C8JQQ9, C8JQR0, P46551, P46552
    Conserved Domains (2) summary
    smart00220
    Location:311 → 605
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd07864
    Location:303 → 605
    STKc_CDK12; Catalytic domain of the Serine/Threonine Kinase, Cyclin-Dependent protein Kinase 12
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P46551.4

Gene LinkOut

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