atf-7 Transcription factor atf-7 [Caenorhabditis elegans] - Gene

Summary

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Official Symbol: atf-7
Official Full Name: Transcription factor atf-7
Primary source: WormBase:WBGene00000223
Locus tag: CELE_C07G2.2
See related: AllianceGenome:WB:WBGene00000223
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Caenorhabditis elegans (strain: Bristol N2)
Lineage: Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary: Enables RNA polymerase II cis-regulatory region sequence-specific DNA binding activity and mitogen-activated protein kinase binding activity. Involved in several processes, including defense response to bacterium; regulation of innate immune response; and regulation of transcription by RNA polymerase II. Acts upstream of or within serotonin biosynthetic process. Located in chromatin and nucleus. Is expressed in body wall musculature; hypodermis; intestine; neurons; and rectal epithelial cell. Orthologous to human ATF2 (activating transcription factor 2); ATF7 (activating transcription factor 7); and CREB5 (cAMP responsive element binding protein 5). [provided by Alliance of Genome Resources, Jan 2025]
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Genomic context

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See atf-7 in Genome Data Viewer

Location:: chromosome: III

Exon count:: 8

Sequence:: Chromosome: III; NC_003281.10 (4491627..4499045, complement)

Chromosome III - NC_003281.10 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003281.10

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Acanthopanax senticosus Polysaccharide Enhances the Pathogen Resistance of Radiation-Damaged Caenorhabditis elegans through Intestinal p38 MAPK-SKN-1/ATF-7 Pathway and Stress Response.
Title: Acanthopanax senticosus Polysaccharide Enhances the Pathogen Resistance of Radiation-Damaged Caenorhabditis elegans through Intestinal p38 MAPK-SKN-1/ATF-7 Pathway and Stress Response.
Loss of muscleblind splicing factor shortens Caenorhabditis elegans lifespan by reducing the activity of p38 MAPK/PMK-1 and transcription factors ATF-7 and Nrf/SKN-1.
Title: Loss of muscleblind splicing factor shortens Caenorhabditis elegans lifespan by reducing the activity of p38 MAPK/PMK-1 and transcription factors ATF-7 and Nrf/SKN-1.
Study shows that ATF-7 regulates a majority of all genes induced by pathogen infection by occupancy in their regulatory regions in a PMK-1-dependent manner. Moreover, a subset of these ATF-7-regulated pathogen-induced target genes supports a direct role for this transcriptional response in host defense. Overall, data suggest that ATF-7 is a direct regulator of immune effector genes that is regulated by PMK-1 p38 MAPK.
Title: Global transcriptional regulation of innate immunity by ATF-7 in C. elegans.
The p38MAPK/ATF-7 immune pathway is triggered by mitochondrial complex I dysfunction.
Title: The Mitochondria-Regulated Immune Pathway Activated in the C. elegans Intestine Is Neuroprotective.
ATF-7 was identified in both ethylmethanesulfonate mutagenesis and candidate gene screens
Title: Identification of ATF-7 and the insulin signaling pathway in the regulation of metallothionein in C. elegans suggests roles in aging and reactive oxygen species.
Phosphorylation of the conserved transcription factor ATF-7 by PMK-1 p38 MAPK regulates innate immunity in Caenorhabditis elegans
Title: Phosphorylation of the conserved transcription factor ATF-7 by PMK-1 p38 MAPK regulates innate immunity in Caenorhabditis elegans.

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Pathways from PubChem

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

C07G2.2 (e-PCR)
- UniSTS:321198

Homology

Orthologs from OrthoDB

Gene Ontology Provided by WormBase

Function	Evidence Code	Pubs
enables DNA-binding transcription factor activity	IEA Inferred from Electronic Annotation more info
enables DNA-binding transcription factor activity	ISS Inferred from Sequence or Structural Similarity more info	PubMed
enables DNA-binding transcription factor activity, RNA polymerase II-specific	IBA Inferred from Biological aspect of Ancestor more info
enables DNA-binding transcription factor activity, RNA polymerase II-specific	ISS Inferred from Sequence or Structural Similarity more info	PubMed
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	IMP Inferred from Mutant Phenotype more info	PubMed
enables cAMP response element binding	IBA Inferred from Biological aspect of Ancestor more info
enables mitogen-activated protein kinase binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in antibacterial innate immune response	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in cellular response to metal ion	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in cellular response to reactive oxygen species	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in defense response to Gram-negative bacterium	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of innate immune response	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of transcription by RNA polymerase II	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of innate immune response	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of transcription by RNA polymerase II	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of DNA-templated transcription	IEA Inferred from Electronic Annotation more info
involved_in regulation of gene expression	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of transcription by RNA polymerase II	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of transcription by RNA polymerase II	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within serotonin biosynthetic process	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in chromatin	IDA Inferred from Direct Assay more info	PubMed
located_in chromosome	IEA Inferred from Electronic Annotation more info
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed
located_in nucleus	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: Transcription factor atf-7

NP_001370161.1

Confirmed by transcript evidence

NP_001379489.1

Confirmed by transcript evidence

NP_497913.1

Confirmed by transcript evidence

NP_497914.2

Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003281.10 Reference assembly

Range

4491627..4499045 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_065513.5 → NP_497914.2 Transcription factor atf-7 [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_497914.2

Status: REVIEWED

UniProtKB/TrEMBL

Q9U3R1

Conserved Domains (2) summary

smart00338
Location:340 → 404

BRLZ; basic region leucin zipper

cd14687
Location:345 → 396

bZIP_ATF2; coiled coil [structural motif]
NM_001393322.1 → NP_001379489.1 Transcription factor atf-7 [Caenorhabditis elegans]

Status: REVIEWED

Conserved Domains (2) summary

smart00338
Location:321 → 372

BRLZ; basic region leucin zipper

cd14687
Location:326 → 372

bZIP_ATF2; coiled coil [structural motif]
NM_065512.5 → NP_497913.1 Transcription factor atf-7 [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_497913.1

Status: REVIEWED

UniProtKB/TrEMBL

Q17801

Conserved Domains (2) summary

smart00338
Location:340 → 407

BRLZ; basic region leucin zipper

cd14687
Location:345 → 399

bZIP_ATF2; coiled coil [structural motif]
NM_001384076.2 → NP_001370161.1 Transcription factor atf-7 [Caenorhabditis elegans]

Status: REVIEWED

UniProtKB/Swiss-Prot

B3GWA6, Q17801, Q86MD3, Q9U3R1

Conserved Domains (2) summary

smart00338
Location:389 → 456

BRLZ; basic region leucin zipper

cd14687
Location:394 → 448

bZIP_ATF2; coiled coil [structural motif]