sel-5 Serine/threonine-protein kinase sel-5 [Caenorhabditis elegans] - Gene

Summary

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Official Symbol: sel-5
Official Full Name: Serine/threonine-protein kinase sel-5
Primary source: WormBase:WBGene00004762
Locus tag: CELE_F35G12.3
See related: AllianceGenome:WB:WBGene00004762
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Caenorhabditis elegans (strain: Bristol N2)
Lineage: Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary: Predicted to enable AP-2 adaptor complex binding activity and protein serine/threonine kinase activity. Predicted to be involved in positive regulation of Notch signaling pathway and regulation of clathrin-dependent endocytosis. Predicted to be active in cytoplasm. Is expressed in reproductive system. Used to study Parkinson's disease. Orthologous to several human genes including AAK1 (AP2 associated kinase 1). [provided by Alliance of Genome Resources, Jan 2025]
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Genomic context

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See sel-5 in Genome Data Viewer

Location:: chromosome: III

Exon count:: 17

Sequence:: Chromosome: III; NC_003281.10 (4571764..4578437, complement)

Chromosome III - NC_003281.10 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003281.10

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Caenorhabditis elegans SEL-5/AAK1 regulates cell migration and cell outgrowth independently of its kinase activity.
Title: Caenorhabditis elegans SEL-5/AAK1 regulates cell migration and cell outgrowth independently of its kinase activity.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

F35G12.3 (e-PCR)
- UniSTS:317484

Homology

Orthologs from OrthoDB

Gene Ontology Provided by WormBase

Function	Evidence Code	Pubs
enables AP-2 adaptor complex binding	IBA Inferred from Biological aspect of Ancestor more info
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables protein kinase activity	IEA Inferred from Electronic Annotation more info
enables protein serine kinase activity	IEA Inferred from Electronic Annotation more info
enables protein serine/threonine kinase activity	IBA Inferred from Biological aspect of Ancestor more info
enables protein serine/threonine kinase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in positive regulation of Notch signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in protein phosphorylation	IEA Inferred from Electronic Annotation more info
involved_in regulation of clathrin-dependent endocytosis	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasm	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: Serine/threonine-protein kinase sel-5

NP_001022562.1

Confirmed by transcript evidence

NP_001022563.1

Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003281.10 Reference assembly

Range

4571764..4578437 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001027391.9 → NP_001022562.1 Serine/threonine-protein kinase sel-5 [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_001022562.1

Status: REVIEWED

UniProtKB/Swiss-Prot

G5ECQ3, G5EFY9

Conserved Domains (2) summary

smart00220
Location:48 → 310

S_TKc; Serine/Threonine protein kinases, catalytic domain

cd14037
Location:43 → 320

STKc_NAK_like; Catalytic domain of Numb-Associated Kinase (NAK)-like Serine/Threonine kinases
NM_001027392.6 → NP_001022563.1 Serine/threonine-protein kinase sel-5 [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_001022563.1

Status: REVIEWED

UniProtKB/Swiss-Prot

G5ECQ3

Conserved Domains (2) summary

smart00220
Location:48 → 310

S_TKc; Serine/Threonine protein kinases, catalytic domain

cl21453
Location:43 → 320

PKc_like; Protein Kinases, catalytic domain