rbg-3 Rab-GAP TBC domain-containing protein [Caenorhabditis elegans] - Gene

Summary

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Official Symbol: rbg-3
Official Full Name: Rab-GAP TBC domain-containing protein
Primary source: WormBase:WBGene00007167
Locus tag: CELE_B0393.2
See related: AllianceGenome:WB:WBGene00007167
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Caenorhabditis elegans (strain: Bristol N2)
Lineage: Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary: Enables GTPase activator activity. Predicted to be involved in retrograde transport, endosome to Golgi. Located in cytoplasm. Is expressed in amphid neurons and phasmid neurons. Used to study obesity. Orthologous to human TBC1D5 (TBC1 domain family member 5). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See rbg-3 in Genome Data Viewer

Location:: chromosome: III

Exon count:: 9

Sequence:: Chromosome: III; NC_003281.10 (4754588..4757017)

Chromosome III - NC_003281.10 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003281.10

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Results found that RBG-3 preferentially stimulates the intrinsic GTPase activity of RAB-7 in both human and C. elegans.
Title: An endocytic pathway as a target of tubby for regulation of fat storage.

Submit: New GeneRIF Correction

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

B0393.1 (e-PCR)
- UniSTS:306037

B0393.2 (e-PCR)
- UniSTS:307183

Homology

Orthologs from OrthoDB

Gene Ontology Provided by WormBase

Function	Evidence Code	Pubs
enables GTPase activator activity	IBA Inferred from Biological aspect of Ancestor more info
enables GTPase activator activity	IDA Inferred from Direct Assay more info	PubMed

Process	Evidence Code	Pubs
involved_in retrograde transport, endosome to Golgi	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
is_active_in Golgi apparatus	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasm	IDA Inferred from Direct Assay more info	PubMed
is_active_in endosome membrane	IBA Inferred from Biological aspect of Ancestor more info
part_of retromer complex	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: Rab-GAP TBC domain-containing protein

NP_497979.1

Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003281.10 Reference assembly

Range

4754588..4757017

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_065578.7 → NP_497979.1 Rab-GAP TBC domain-containing protein [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_497979.1

Status: REVIEWED

UniProtKB/TrEMBL

Q17491

Conserved Domains (1) summary

smart00164
Location:37 → 344

TBC; Domain in Tre-2, BUB2p, and Cdc16p. Probable Rab-GAPs