U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

mmab-1 Cobalamin adenosyltransferase-like domain-containing protein [ Caenorhabditis elegans ]

Gene ID: 175661, updated on 4-Jan-2025

Summary

Go to the top of the page Help
Official Symbol
mmab-1
Official Full Name
Cobalamin adenosyltransferase-like domain-containing protein
Primary source
WormBase:WBGene00016144
Locus tag
CELE_C26E6.11
See related
AllianceGenome:WB:WBGene00016144
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Predicted to enable corrinoid adenosyltransferase activity. Used to study methylmalonic acidemia. Human ortholog(s) of this gene implicated in inherited metabolic disorder and methylmalonic acidemia cblB type. Orthologous to human MMAB (metabolism of cobalamin associated B). [provided by Alliance of Genome Resources, Jan 2025]
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
See mmab-1 in Genome Data Viewer
Location:
chromosome: III
Exon count:
4
Sequence:
Chromosome: III; NC_003281.10 (4920442..4921747, complement)

Chromosome III - NC_003281.10Genomic Context describing neighboring genes Neighboring gene putative DNA-directed RNA polymerases I, II, and III subunit RPABC3 Neighboring gene NEDD8-activating enzyme E1 regulatory subunit Neighboring gene Histone-lysine N-methyltransferase set-2 Neighboring gene OBG-type G domain-containing protein

Genomic regions, transcripts, and products

Go to the top of the page Help
Genomic Sequence:
NC_003281.10

Go to nucleotide: Graphics FASTA GenBank

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. A dodecylamine derivative of cyanocobalamin potently inhibits the activities of cobalamin-dependent methylmalonyl-CoA mutase and methionine synthase of Caenorhabditis elegans. Bito T, et al. FEBS Open Bio, 2014. PMID 25161880, Free PMC Article
  2. Propionyl-CoA and adenosylcobalamin metabolism in Caenorhabditis elegans: evidence for a role of methylmalonyl-CoA epimerase in intermediary metabolism. Chandler RJ, et al. Mol Genet Metab, 2006 Sep-Oct. PMID 16843692, Free PMC Article
  3. Biochemistry, function, and deficiency of vitamin B12 in Caenorhabditis elegans. Bito T, et al. Exp Biol Med (Maywood), 2016 Sep. PMID 27486161, Free PMC Article
  4. A global analysis of genetic interactions in Caenorhabditis elegans. Byrne AB, et al. J Biol, 2007. PMID 17897480, Free PMC Article
  5. EPIC: software toolkit for elution profile-based inference of protein complexes. Hu LZ, et al. Nat Methods, 2019 Aug. PMID 31308550, Free PMC Article

See all (8) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

Go to the top of the page Help
Products Interactant Other Gene Complex Source Pubs Description

General gene information

Go to the top of the page Help

Markers

Homology

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables corrinoid adenosyltransferase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables corrinoid adenosyltransferase activity IEA
Inferred from Electronic Annotation
more info
  
enables transferase activity IEA
Inferred from Electronic Annotation
more info
  

General protein information

Go to the top of the page Help
Preferred Names
Cobalamin adenosyltransferase-like domain-containing protein
NP_001379723.1
  • Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003281.10 Reference assembly

    Range
    4920442..4921747 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001392082.1 → NP_001379723.1  Cobalamin adenosyltransferase-like domain-containing protein [Caenorhabditis elegans]

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q18218
    Conserved Domains (1) summary
    pfam01923
    Location:15 → 183
    Cob_adeno_trans; Cobalamin adenosyltransferase
Nucleotide Protein
Heading Accession and Version

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Molecular Biology Databases
Research Materials
Tools