ulp-1 Sentrin-specific protease [Caenorhabditis elegans] - Gene

Summary

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Official Symbol: ulp-1
Official Full Name: Sentrin-specific protease
Primary source: WormBase:WBGene00006736
Locus tag: CELE_T10F2.3
See related: AllianceGenome:WB:WBGene00006736
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Caenorhabditis elegans (strain: Bristol N2)
Lineage: Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary: Predicted to enable deSUMOylase activity. Involved in several processes, including embryo development; positive regulation of error-prone translesion synthesis; and protein desumoylation. Predicted to be located in nuclear envelope. Predicted to be active in nucleus. Orthologous to several human genes including SENP2 (SUMO specific peptidase 2). [provided by Alliance of Genome Resources, Jan 2025]
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Genomic context

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See ulp-1 in Genome Data Viewer

Location:: chromosome: III

Exon count:: 10

Sequence:: Chromosome: III; NC_003281.10 (5165659..5169799, complement)

Chromosome III - NC_003281.10 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003281.10

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Study using C. elegans as a model system found that SUMO promotes the stability of the ring complex (RC) and that RC disassembly is dependent on targeting the SUMO protease ULP-1 to the structures, suggesting that ULP-1 could promote RC disassembly upon removal of the E2/E3 enzymes in early anaphase.
Title: Dynamic SUMO remodeling drives a series of critical events during the meiotic divisions in Caenorhabditis elegans.

Submit: New GeneRIF Correction

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

T10F2.4 (e-PCR)
- UniSTS:310791

T10F2.3 (e-PCR)
- UniSTS:314961

Homology

Orthologs from OrthoDB

Gene Ontology Provided by WormBase

Function	Evidence Code	Pubs
enables cysteine-type peptidase activity	IEA Inferred from Electronic Annotation more info
enables deSUMOylase activity	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in embryo development ending in birth or egg hatching	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of error-prone translesion synthesis	IGI Inferred from Genetic Interaction more info	PubMed
involved_in positive regulation of error-prone translesion synthesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in protein desumoylation	IBA Inferred from Biological aspect of Ancestor more info
involved_in protein desumoylation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in proteolysis	IEA Inferred from Electronic Annotation more info
involved_in regulation of protein localization	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in nuclear envelope	IEA Inferred from Electronic Annotation more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: Sentrin-specific protease

NP_498095.3

Partially confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003281.10 Reference assembly

Range

5165659..5169799 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_065694.9 → NP_498095.3 Sentrin-specific protease [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_498095.3

Status: REVIEWED

UniProtKB/Swiss-Prot

Q09353, Q8IU18

Conserved Domains (1) summary

cl23802
Location:425 → 692

Peptidase_C48; Ulp1 protease family, C-terminal catalytic domain