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osg-1 Rho guanine nucleotide exchange factor osg-1 [ Caenorhabditis elegans ]

Gene ID: 175756, updated on 4-Jan-2025

Summary

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Official Symbol
osg-1
Official Full Name
Rho guanine nucleotide exchange factor osg-1
Primary source
WormBase:WBGene00019832
Locus tag
CELE_R02F2.2
See related
AllianceGenome:WB:WBGene00019832
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Predicted to enable guanyl-nucleotide exchange factor activity. Involved in response to oxidative stress. Predicted to be active in cytoplasm. Is expressed in body wall musculature and head neurons. Orthologous to human ARHGEF17 (Rho guanine nucleotide exchange factor 17). [provided by Alliance of Genome Resources, Jan 2025]
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Genomic context

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See osg-1 in Genome Data Viewer
Location:
chromosome: III
Exon count:
17
Sequence:
Chromosome: III; NC_003281.10 (5487553..5498958)

Chromosome III - NC_003281.10Genomic Context describing neighboring genes Neighboring gene Prion-like-(Q/N-rich)-domain-bearing protein Neighboring gene Myb-binding protein 1A-like protein Neighboring gene Chitin-binding type-2 domain-containing protein Neighboring gene Amino acid transporter transmembrane domain-containing protein Neighboring gene Large ribosomal subunit protein mL62 Neighboring gene Cyclin-like domain-containing protein

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003281.10

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Cytoskeletal remodeling via Rho GTPases during oxidative and thermal stress in Caenorhabditis elegans. Patel R, et al. Biochem Biophys Res Commun, 2017 Oct 21. PMID 28859988, Free PMC Article
  2. Guanine nucleotide exchange factor OSG-1 confers functional aging via dysregulated Rho signaling in Caenorhabditis elegans neurons. Duan Z, et al. Genetics, 2015 Feb. PMID 25527286, Free PMC Article
  3. CGEF-1 and CHIN-1 regulate CDC-42 activity during asymmetric division in the Caenorhabditis elegans embryo. Kumfer KT, et al. Mol Biol Cell, 2010 Jan 15. PMID 19923324, Free PMC Article
  4. OrthoList: a compendium of C. elegans genes with human orthologs. Shaye DD, et al. PLoS One, 2011. PMID 21647448, Free PMC Article
  5. OrthoList 2: A New Comparative Genomic Analysis of Human and Caenorhabditis elegans Genes. Kim W, et al. Genetics, 2018 Oct. PMID 30120140, Free PMC Article

See all (6) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
enables guanyl-nucleotide exchange factor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables guanyl-nucleotide exchange factor activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in actin cytoskeleton organization IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in response to oxidative stress IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
Rho guanine nucleotide exchange factor osg-1
NP_498172.3
  • Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003281.10 Reference assembly

    Range
    5487553..5498958
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_065771.7 → NP_498172.3  Rho guanine nucleotide exchange factor osg-1 [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_498172.3

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q21653
    Conserved Domains (2) summary
    smart00325
    Location:361 → 543
    RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases
    cl17171
    Location:524 → 612
    PH-like; Pleckstrin homology-like domain
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q21653.4

Gene LinkOut

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