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gcna-1 Germ cell nuclear acidic-1 protein [ Caenorhabditis elegans ]

Gene ID: 175850, updated on 4-Jan-2025

Summary

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Official Symbol
gcna-1
Official Full Name
Germ cell nuclear acidic-1 protein
Primary source
WormBase:WBGene00022694
Locus tag
CELE_ZK328.4
See related
AllianceGenome:WB:WBGene00022694
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Enables SUMO polymer binding activity. Involved in meiotic chromosome segregation and protein-DNA covalent cross-linking repair. Located in PML body and condensed chromosome. Is expressed in Z2; Z3; and germ cell. Human ortholog(s) of this gene implicated in X-linked spermatogenic failure 4. Orthologous to human GCNA (germ cell nuclear acidic peptidase). [provided by Alliance of Genome Resources, Jan 2025]
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Genomic context

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See gcna-1 in Genome Data Viewer
Location:
chromosome: III
Exon count:
7
Sequence:
Chromosome: III; NC_003281.10 (6006344..6009084, complement)

Chromosome III - NC_003281.10Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene Secreted protein Neighboring gene Rho GTPase-activating protein 26;SH3 domain-containing protein Neighboring gene ncRNA Neighboring gene Tr-type G domain-containing protein Neighboring gene Nuclear pore complex protein Nup98 Neighboring gene ncRNA

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003281.10

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. SUMOylation promotes protective responses to DNA-protein crosslinks. Borgermann N, et al. EMBO J, 2019 Apr 15. PMID 30914427, Free PMC Article
  2. A widely employed germ cell marker is an ancient disordered protein with reproductive functions in diverse eukaryotes. Carmell MA, et al. Elife, 2016 Oct 8. PMID 27718356, Free PMC Article
  3. GCNA Interacts with Spartan and Topoisomerase II to Regulate Genome Stability. Dokshin GA, et al. Dev Cell, 2020 Jan 6. PMID 31839538, Free PMC Article
  4. GCNA Preserves Genome Integrity and Fertility Across Species. Bhargava V, et al. Dev Cell, 2020 Jan 6. PMID 31839537, Free PMC Article
  5. OrthoList: a compendium of C. elegans genes with human orthologs. Shaye DD, et al. PLoS One, 2011. PMID 21647448, Free PMC Article

See all (7) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
enables SUMO polymer binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables molecular_function ND
No biological Data available
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in DNA metabolic process IEA
Inferred from Electronic Annotation
more info
  
involved_in meiotic chromosome segregation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in protein-DNA covalent cross-linking repair IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in response to stress IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in PML body IDA
Inferred from Direct Assay
more info
 PubMed 
located_in chromosome IEA
Inferred from Electronic Annotation
more info
  
located_in condensed chromosome IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
Germ cell nuclear acidic-1 protein
NP_498307.1
  • Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003281.10 Reference assembly

    Range
    6006344..6009084 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_065906.5 → NP_498307.1  Germ cell nuclear acidic-1 protein [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_498307.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q23462
    Conserved Domains (1) summary
    smart00731
    Location:296 → 451
    SprT; SprT homologues
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q23462.2

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