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gar-2 G-protein coupled receptors family 1 profile domain-containing protein;Muscarinic acetylcholine receptor gar-2 [ Caenorhabditis elegans ]

Gene ID: 175893, updated on 9-Dec-2024

Summary

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Official Symbol
gar-2
Official Full Name
G-protein coupled receptors family 1 profile domain-containing protein;Muscarinic acetylcholine receptor gar-2
Primary source
WormBase:WBGene00001518
Locus tag
CELE_F47D12.1
See related
AllianceGenome:WB:WBGene00001518
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Enables G protein-coupled acetylcholine receptor activity. Involved in G protein-coupled receptor signaling pathway; negative regulation of cholinergic synaptic transmission; and response to xenobiotic stimulus. Located in axon. Is expressed in neurons. [provided by Alliance of Genome Resources, Dec 2024]
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Genomic context

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See gar-2 in Genome Data Viewer
Location:
chromosome: III
Exon count:
12
Sequence:
Chromosome: III; NC_003281.10 (6309366..6320873)

Chromosome III - NC_003281.10Genomic Context describing neighboring genes Neighboring gene Kelch repeat and BTB domain-containing protein F47D12.7 Neighboring gene Uncharacterized protein Neighboring gene WD_REPEATS_REGION domain-containing protein;putative WD repeat-containing protein F47D12.9 Neighboring gene ncRNA Neighboring gene Protein kinase domain-containing protein Neighboring gene ncRNA

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003281.10

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Three functional isoforms of GAR-2, a Caenorhabditis elegans G-protein-linked acetylcholine receptor, are produced by alternative splicing. Suh SJ, et al. Biochem Biophys Res Commun, 2001 Nov 16. PMID 11700045
  2. Metabotropic histamine receptors--nothing for invertebrates? Roeder T. Eur J Pharmacol, 2003 Apr 11. PMID 12679144
  3. Characterization of GAR-2, a novel G protein-linked acetylcholine receptor from Caenorhabditis elegans. Lee YS, et al. J Neurochem, 2000 Nov. PMID 11032868
  4. Novel actions of arecoline in the C. elegans motor circuit. McCulloch KA, et al. MicroPubl Biol, 2020 Jul 1. PMID 32666042, Free PMC Article
  5. Behavioral impact of neurotransmitter-activated G-protein-coupled receptors: muscarinic and GABAB receptors regulate Caenorhabditis elegans locomotion. Dittman JS, et al. J Neurosci, 2008 Jul 9. PMID 18614679, Free PMC Article

See all (28) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Collectively, these results suggest decreased SMN leads to defective microRNA function via MEL-46 misregulation, followed by increased M2 muscarinic receptor expression, and neuronal dysfunction in Spinal Muscular Atrophy.
    Title: Decreased microRNA levels lead to deleterious increases in neuronal M2 muscarinic receptors in Spinal Muscular Atrophy models.
  2. This study identify a muscarinic receptor (GAR-2) and the GABA(B) receptor dimer (GBB-1/2) that detect synaptically released ACh and GABA and regulate the locomotion.
    Title: Behavioral impact of neurotransmitter-activated G-protein-coupled receptors: muscarinic and GABAB receptors regulate Caenorhabditis elegans locomotion.
Submit: New GeneRIF Correction

General gene information

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Markers

Homology

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
enables G protein-coupled acetylcholine receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables G protein-coupled acetylcholine receptor activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables G protein-coupled acetylcholine receptor activity IEA
Inferred from Electronic Annotation
more info
  
enables G protein-coupled acetylcholine receptor activity IGI
Inferred from Genetic Interaction
more info
 PubMed 
enables G protein-coupled acetylcholine receptor activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
enables G protein-coupled amine receptor activity IEA
Inferred from Electronic Annotation
more info
  
enables G protein-coupled receptor activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in G protein-coupled acetylcholine receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
  
involved_in G protein-coupled receptor signaling pathway IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in G protein-coupled receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
  
involved_in G protein-coupled receptor signaling pathway IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in G protein-coupled receptor signaling pathway IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in G protein-coupled serotonin receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
  
involved_in adenylate cyclase-inhibiting G protein-coupled acetylcholine receptor signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in cellular response to nitrogen compound IEA
Inferred from Electronic Annotation
more info
  
involved_in chemical synaptic transmission IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in negative regulation of synaptic transmission, cholinergic IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in negative regulation of synaptic transmission, cholinergic IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in response to xenobiotic stimulus IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in response to xenobiotic stimulus IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in axon IDA
Inferred from Direct Assay
more info
 PubMed 
located_in axon IEA
Inferred from Electronic Annotation
more info
  
located_in cell projection IEA
Inferred from Electronic Annotation
more info
  
is_active_in dendrite IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
  
is_active_in synapse IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in synapse IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
G-protein coupled receptors family 1 profile domain-containing protein;Muscarinic acetylcholine receptor gar-2
NP_001022593.1
  • Confirmed by transcript evidence
NP_001022594.1
  • Confirmed by transcript evidence
NP_001022596.1
  • Partially confirmed by transcript evidence
NP_001022597.1
  • Confirmed by transcript evidence
NP_001368076.1
  • Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003281.10 Reference assembly

    Range
    6309366..6320873
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001027423.7 → NP_001022594.1  Muscarinic acetylcholine receptor gar-2 [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_001022594.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q09388
    Conserved Domains (2) summary
    pfam00001
    Location:22 → 210
    7tm_1; 7 transmembrane receptor (rhodopsin family)
    cl21561
    Location:16 → 214
    7tm_4; Olfactory receptor

  2. NM_001379757.3 → NP_001368076.1  G-protein coupled receptors family 1 profile domain-containing protein [Caenorhabditis elegans]

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q8MQ41, Q8MTW9
    Conserved Domains (3) summary
    cd15302
    Location:6 → 199
    7tmA_mAChR_GAR-2-like; muscarinic acetylcholine receptor GAR-2 and similar proteins, member of the class A family of seven-transmembrane G protein-coupled receptors
    cd14964
    Location:578 → 608
    7tm_GPCRs; TM helix 6 [structural motif]
    cl28897
    Location:575 → 653
    7tm_GPCRs; seven-transmembrane G protein-coupled receptor superfamily

  3. NM_001027422.5 → NP_001022593.1  Muscarinic acetylcholine receptor gar-2 [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_001022593.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q09388, Q09561, Q95WX7
    Conserved Domains (2) summary
    pfam00001
    Location:22 → 210
    7tm_1; 7 transmembrane receptor (rhodopsin family)
    cl21561
    Location:16 → 214
    7tm_4; Olfactory receptor

  4. NM_001027425.5 → NP_001022596.1  G-protein coupled receptors family 1 profile domain-containing protein [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_001022596.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q8MQ40
    Conserved Domains (2) summary
    cd14964
    Location:7 → 33
    7tm_GPCRs; TM helix 1 [structural motif]
    cl28897
    Location:6 → 199
    7tm_GPCRs; seven-transmembrane G protein-coupled receptor superfamily

  5. NM_001027426.5 → NP_001022597.1  G-protein coupled receptors family 1 profile domain-containing protein [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_001022597.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q8I7J8
    Conserved Domains (2) summary
    cd14964
    Location:248 → 278
    7tm_GPCRs; TM helix 6 [structural motif]
    cl28897
    Location:245 → 323
    7tm_GPCRs; seven-transmembrane G protein-coupled receptor superfamily
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q09388.3

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