let-765 Protein strawberry notch homolog [Caenorhabditis elegans] - Gene

Summary

Go to the top of the page Help

Official Symbol: let-765
Official Full Name: Protein strawberry notch homolog
Primary source: WormBase:WBGene00002889
Locus tag: CELE_F20H11.2
See related: AllianceGenome:WB:WBGene00002889
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Caenorhabditis elegans (strain: Bristol N2)
Lineage: Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary: Predicted to enable chromatin DNA binding activity and histone binding activity. Involved in several processes, including nematode male tail tip morphogenesis; positive regulation of Ras protein signal transduction; and vulval cell fate specification. Located in nucleus. Is expressed in several structures, including P3.p hermaphrodite; P4.p hermaphrodite; P5.p hermaphrodite; P6.p hermaphrodite; and P7.p hermaphrodite. Orthologous to several human genes including SBNO1 (strawberry notch homolog 1). [provided by Alliance of Genome Resources, Nov 2024]
NEW: Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help

See let-765 in Genome Data Viewer

Location:: chromosome: III

Exon count:: 15

Sequence:: Chromosome: III; NC_003281.10 (6592525..6601173, complement)

Chromosome III - NC_003281.10 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to reference sequence details

Genomic Sequence:: NC_003281.10

Go to nucleotide: Graphics FASTA GenBank

Bibliography

Go to the top of the page Help

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

NSH1 also able to hydrolyze xanthosine with high efficiency. NSH2 functions as a cytosolic, inosine-specific hydrolase induced by senescence. NSH3 encodes a purine hydrolase involved in extracellular nucleotide salvage.
Title: Arabidopsis nucleoside hydrolases involved in intracellular and extracellular degradation of purines.
Study identified a novel regulator of EGFR/RAS signaling, let-765/nsh-1, that functions upstream of the pathway to promote vulval induction; let-765 encodes a conserved DExD/H box helicase protein and is the ortholog of Drosophila strawberry notch.
Title: A strawberry notch homolog, let-765/nsh-1, positively regulates lin-3/egf expression to promote RAS-dependent vulval induction in C. elegans.
Notch and Prospero repress proliferation following cyclin E overexpression in bristle cell lineage.
Title: Notch and Prospero repress proliferation following cyclin E overexpression in the Drosophila bristle lineage.

Submit: New GeneRIF Correction

Interactions

Go to the top of the page Help

Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

Go to the top of the page Help

Markers

F20H11.2 (e-PCR)
- UniSTS:309856

F20H11.6 (e-PCR)
- UniSTS:317657

Homology

Orthologs from OrthoDB

Gene Ontology Provided by WormBase

Function	Evidence Code	Pubs
enables chromatin DNA binding	IBA Inferred from Biological aspect of Ancestor more info
enables histone binding	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in nematode male tail tip morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of Ras protein signal transduction	IGI Inferred from Genetic Interaction more info	PubMed
involved_in positive regulation of cell fate specification	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of DNA-templated transcription	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of DNA-templated transcription	IEA Inferred from Electronic Annotation more info
involved_in regulation of response to stimulus	IEA Inferred from Electronic Annotation more info
involved_in vulval cell fate specification	IGI Inferred from Genetic Interaction more info	PubMed
involved_in vulval cell fate specification	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed
located_in nucleus	IEA Inferred from Electronic Annotation more info

General protein information

Go to the top of the page Help

Preferred Names: Protein strawberry notch homolog

NP_498455.2

Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003281.10 Reference assembly

Range

6592525..6601173 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_066054.6 → NP_498455.2 Protein strawberry notch homolog [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_498455.2

Status: REVIEWED

UniProtKB/Swiss-Prot

D5LYH1, O01737

Conserved Domains (2) summary

pfam13871
Location:1352 → 1630

Helicase_C_4; C-terminal domain on Strawberry notch homolog

pfam13872
Location:632 → 936

AAA_34; P-loop containing NTP hydrolase pore-1