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isw-1 Chromatin-remodeling complex ATPase chain isw-1 [ Caenorhabditis elegans ]

Gene ID: 175944, updated on 9-Dec-2024

Summary

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Official Symbol
isw-1
Official Full Name
Chromatin-remodeling complex ATPase chain isw-1
Primary source
WormBase:WBGene00002169
Locus tag
CELE_F37A4.8
See related
AllianceGenome:WB:WBGene00002169
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Predicted to enable DNA binding activity; chromatin binding activity; and nucleosome array spacer activity. Involved in positive regulation of transcription by RNA polymerase II and positive regulation of vulval development. Located in chromatin. Is expressed in several structures, including developing hermaphrodite gonad; head; intestine; pharynx; and vulva. Orthologous to several human genes including SMARCA1 (SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 1). [provided by Alliance of Genome Resources, Dec 2024]
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Genomic context

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See isw-1 in Genome Data Viewer
Location:
chromosome: III
Exon count:
11
Sequence:
Chromosome: III; NC_003281.10 (6703988..6710100, complement)

Chromosome III - NC_003281.10Genomic Context describing neighboring genes Neighboring gene Rabphilin-1 Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene Uncharacterized protein Neighboring gene Uncharacterized protein Neighboring gene Ankyrin repeat-containing protein F37A4.4

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003281.10

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. The chromatin remodeling factor ISW-1 integrates organismal responses against nuclear and mitochondrial stress. Matilainen O, et al. Nat Commun, 2017 Nov 28. PMID 29180639, Free PMC Article
  2. LSY-2 is essential for maintaining the germ-soma distinction in C. elegans. Lin L, et al. Protein Cell, 2015 Aug. PMID 26050091, Free PMC Article
  3. The miR-58 microRNA family is regulated by insulin signaling and contributes to lifespan regulation in Caenorhabditis elegans. Zhang Y, et al. Sci China Life Sci, 2018 Sep. PMID 29948901
  4. Hypoxia-inducible Factor-1 (HIF-1)-independent hypoxia response of the small heat shock protein hsp-16.1 gene regulated by chromatin-remodeling factors in the nematode Caenorhabditis elegans. Lee J, et al. J Biol Chem, 2013 Jan 18. PMID 23229554, Free PMC Article
  5. Gene expression: long-term gene silencing by RNAi. Vastenhouw NL, et al. Nature, 2006 Aug 24. PMID 16929289

See all (26) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables ATP-dependent chromatin remodeler activity IEA
Inferred from Electronic Annotation
more info
  
enables DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables DNA binding IEA
Inferred from Electronic Annotation
more info
  
enables chromatin binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables helicase activity IEA
Inferred from Electronic Annotation
more info
  
enables hydrolase activity IEA
Inferred from Electronic Annotation
more info
  
enables nucleosome array spacer activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables nucleosome binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in chromatin organization IEA
Inferred from Electronic Annotation
more info
  
involved_in chromatin remodeling IEA
Inferred from Electronic Annotation
more info
  
involved_in heterochromatin formation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in positive regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in positive regulation of transcription by RNA polymerase II IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of vulval development IGI
Inferred from Genetic Interaction
more info
 PubMed 
Component Evidence Code Pubs
located_in chromatin IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in chromatin IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
Chromatin-remodeling complex ATPase chain isw-1
NP_001379931.1
  • Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003281.10 Reference assembly

    Range
    6703988..6710100 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001392127.1 → NP_001379931.1  Chromatin-remodeling complex ATPase chain isw-1 [Caenorhabditis elegans]

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    P41877
    Conserved Domains (1) summary
    PLN03142
    Location:48 → 1008
    PLN03142; Probable chromatin-remodeling complex ATPase chain; Provisional
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P41877.2

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