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ogt-1 UDP-N-acetylglucosamine--peptide N-acetylglucosaminyltransferase;protein O-GlcNAc transferase [ Caenorhabditis elegans ]

Gene ID: 176000, updated on 4-Jan-2025

Summary

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Official Symbol
ogt-1
Official Full Name
UDP-N-acetylglucosamine--peptide N-acetylglucosaminyltransferase;protein O-GlcNAc transferase
Primary source
WormBase:WBGene00003858
Locus tag
CELE_K04G7.3
See related
AllianceGenome:WB:WBGene00003858
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Enables protein N-acetylglucosaminyltransferase activity; protein O-acetylglucosaminyltransferase activity; and protein serine/threonine phosphatase activity. Involved in several processes, including dauer larval development; glycogen metabolic process; and lipid storage. Located in nucleus and perinuclear region of cytoplasm. Is expressed in several structures, including intestine. Used to study diabetes mellitus and type 2 diabetes mellitus. Human ortholog(s) of this gene implicated in non-syndromic X-linked intellectual disability 106. Orthologous to human OGT (O-linked N-acetylglucosamine (GlcNAc) transferase). [provided by Alliance of Genome Resources, Jan 2025]
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Genomic context

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See ogt-1 in Genome Data Viewer
Location:
chromosome: III
Exon count:
13
Sequence:
Chromosome: III; NC_003281.10 (7145842..7153797, complement)

Chromosome III - NC_003281.10Genomic Context describing neighboring genes Neighboring gene Glutamate receptor 2 Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene Deoxynucleoside kinase domain-containing protein;NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 10, mitochondrial Neighboring gene U1 small nuclear ribonucleoprotein 70 kDa

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003281.10

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. O-GlcNAc signaling increases neuron regeneration through one-carbon metabolism in Caenorhabditis elegans. Yadav DK, et al. Elife, 2024 Feb 9. PMID 38334260, Free PMC Article
  2. Nutrient-Driven O-GlcNAcylation at Promoters Impacts Genome-Wide RNA Pol II Distribution. Krause MW, et al. Front Endocrinol (Lausanne), 2018. PMID 30250452, Free PMC Article
  3. Identification and correction of abnormal, incomplete and mispredicted proteins in public databases. Nagy A, et al. BMC Bioinformatics, 2008 Aug 27. PMID 18752676, Free PMC Article
  4. A critical perspective of the diverse roles of O-GlcNAc transferase in chromatin. Gambetta MC, et al. Chromosoma, 2015 Dec. PMID 25894967, Free PMC Article
  5. ELT-2 promotes O-GlcNAc transferase OGT-1 expression to modulate Caenorhabditis elegans lifespan. Su L, et al. J Cell Biochem, 2020 Dec. PMID 32628333

See all (49) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. OGT-1 regulates synaptic assembly through the insulin signaling pathway.
    Title: OGT-1 regulates synaptic assembly through the insulin signaling pathway.
  2. O-GlcNAc transferase OGT-1 and the ubiquitin ligase EEL-1 modulate seizure susceptibility in C. elegans.
    Title: O-GlcNAc transferase OGT-1 and the ubiquitin ligase EEL-1 modulate seizure susceptibility in C. elegans.
  3. The O-GlcNAc transferase OGT is a conserved and essential regulator of the cellular and organismal response to hypertonic stress.
    Title: The O-GlcNAc transferase OGT is a conserved and essential regulator of the cellular and organismal response to hypertonic stress.
  4. findings demonstrate that OGT-1 and EEL-1 form a conserved signaling complex and function together to affect GABA neuron function
    Title: A complex containing the O-GlcNAc transferase OGT-1 and the ubiquitin ligase EEL-1 regulates GABA neuron function.
  5. The Caenorhabditis elegans orthologues of Ca(2+)/calmodulin-dependent kinases CaMK1/4, CMK-1, and O-linked N-acetylglucosamine (O-GlcNAc) transferase, OGT-1, both function in primary sensory neurons to inhibit habituation at short interstimulus interval (ISI) and promote it at long ISIs.
    Title: Insights into the roles of CMK-1 and OGT-1 in interstimulus interval-dependent habituation in Caenorhabditis elegans.
  6. The participation of nutrient sensor OGT-1 in an immunity module evolutionarily conserved from C. elegans to humans reveals an unexplored nexus between nutrient availability and a pathogen-specific immune response.
    Title: Conserved nutrient sensor O-GlcNAc transferase is integral to C. elegans pathogen-specific immunity.
  7. Data show that glucose stress, oga-1 mutants, and ogt-1 mutants each result in an increase in daf-2 carbohydrate storage.
    Title: O-linked-N-acetylglucosamine cycling and insulin signaling are required for the glucose stress response in Caenorhabditis elegans.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
enables glycosyltransferase activity IEA
Inferred from Electronic Annotation
more info
  
enables protein N-acetylglucosaminyltransferase activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
enables protein N-acetylglucosaminyltransferase activity ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
enables protein O-acetylglucosaminyltransferase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables protein O-acetylglucosaminyltransferase activity IEA
Inferred from Electronic Annotation
more info
  
enables protein O-acetylglucosaminyltransferase activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
enables protein serine/threonine phosphatase activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Process Evidence Code Pubs
involved_in UDP-N-acetylglucosamine biosynthetic process ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
involved_in dauer larval development IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in energy reserve metabolic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in glycogen metabolic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in glycoprotein metabolic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in lipid storage IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in protein O-linked glycosylation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in protein O-linked glycosylation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in protein glycosylation IEA
Inferred from Electronic Annotation
more info
  
involved_in reproductive process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in response to temperature stimulus IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in nucleus IDA
Inferred from Direct Assay
more info
 PubMed 
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  
located_in perinuclear region of cytoplasm IDA
Inferred from Direct Assay
more info
 PubMed 
located_in perinuclear region of cytoplasm IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
UDP-N-acetylglucosamine--peptide N-acetylglucosaminyltransferase;protein O-GlcNAc transferase
NP_001040860.1
  • Confirmed by transcript evidence
NP_001040861.1
  • Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003281.10 Reference assembly

    Range
    7145842..7153797 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001047395.5 → NP_001040860.1  UDP-N-acetylglucosamine--peptide N-acetylglucosaminyltransferase [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_001040860.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    O18158, Q21232
    Conserved Domains (8) summary
    COG0457
    Location:308 → 565
    TPR; Tetratricopeptide (TPR) repeat [General function prediction only]
    sd00006
    Location:465 → 493
    TPR; TPR repeat [structural motif]
    cd15832
    Location:330 → 375
    SNAP; TPR repeat [structural motif]
    pfam00515
    Location:499 → 530
    TPR_1; Tetratricopeptide repeat
    pfam13414
    Location:193 → 258
    TPR_11; TPR repeat
    pfam13424
    Location:257 → 327
    TPR_12; Tetratricopeptide repeat
    pfam13844
    Location:663 → 1129
    Glyco_transf_41; Glycosyl transferase family 41
    cl24038
    Location:330 → 534
    SNAP; Soluble N-ethylmaleimide-sensitive factor (NSF) Attachment Protein family

  2. NM_001047396.5 → NP_001040861.1  protein O-GlcNAc transferase [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_001040861.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q2L6Y4
    Conserved Domains (3) summary
    TIGR02917
    Location:21 → 422
    PEP_TPR_lipo; putative PEP-CTERM system TPR-repeat lipoprotein
    sd00006
    Location:287 → 315
    TPR; TPR repeat [structural motif]
    pfam13844
    Location:485 → 951
    Glyco_transf_41; Glycosyl transferase family 41
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
O18158.2

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