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kap-1 Kinesin-associated protein [ Caenorhabditis elegans ]

Gene ID: 176041, updated on 2-Nov-2024

Summary

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Official Symbol
kap-1
Official Full Name
Kinesin-associated protein
Primary source
WormBase:WBGene00002182
Locus tag
CELE_F08F8.3
See related
AllianceGenome:WB:WBGene00002182
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Contributes to microtubule motor activity. Involved in intraciliary anterograde transport; negative regulation of non-motile cilium assembly; and positive regulation of non-motile cilium assembly. Located in ciliary transition zone and non-motile cilium. Part of axonemal heterotrimeric kinesin-II complex. Is expressed in body wall musculature; enteric muscle; intestine; and nervous system. Orthologous to human KIFAP3 (kinesin associated protein 3). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See kap-1 in Genome Data Viewer
Location:
chromosome: III
Exon count:
15
Sequence:
Chromosome: III; NC_003281.10 (7338835..7343667)

Chromosome III - NC_003281.10Genomic Context describing neighboring genes Neighboring gene BCAS3 WD40 domain-containing protein Neighboring gene Serine/threonine-protein phosphatase PP1-beta Neighboring gene ncRNA Neighboring gene Uncharacterized protein Neighboring gene Ribulose-phosphate 3-epimerase Neighboring gene Golgi SNAP receptor complex member 1

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003281.10

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Regulation of a heterodimeric kinesin-2 through an unprocessive motor domain that is turned processive by its partner. Brunnbauer M, et al. Proc Natl Acad Sci U S A, 2010 Jun 8. PMID 20498083, Free PMC Article
  2. Molecular characterization of an anchor protein (AKAPCE) that binds the RI subunit (RCE) of type I protein kinase A from Caenorhabditis elegans. Angelo R, et al. J Biol Chem, 1998 Jun 5. PMID 9603981
  3. Direct imaging of intraflagellar-transport turnarounds reveals that motors detach, diffuse, and reattach to opposite-direction trains. Zhang Z, et al. Proc Natl Acad Sci U S A, 2021 Nov 9. PMID 34732580, Free PMC Article
  4. Two heteromeric kinesin complexes in chemosensory neurons and sensory cilia of Caenorhabditis elegans. Signor D, et al. Mol Biol Cell, 1999 Feb. PMID 9950681, Free PMC Article
  5. Two anterograde intraflagellar transport motors cooperate to build sensory cilia on C. elegans neurons. Snow JJ, et al. Nat Cell Biol, 2004 Nov. PMID 15489852

See all (46) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
enables kinesin binding IEA
Inferred from Electronic Annotation
more info
  
contributes_to microtubule motor activity IDA
Inferred from Direct Assay
more info
 PubMed 
Process Evidence Code Pubs
involved_in cilium organization IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in intraciliary anterograde transport IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in intraciliary anterograde transport IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in microtubule-based movement IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in microtubule-based movement IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in negative regulation of non-motile cilium assembly IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in positive regulation of non-motile cilium assembly IGI
Inferred from Genetic Interaction
more info
 PubMed 
Component Evidence Code Pubs
part_of axonemal heterotrimeric kinesin-II complex IPI
Inferred from Physical Interaction
more info
 PubMed 
is_active_in axoneme IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in ciliary transition zone IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in ciliary transition zone IDA
Inferred from Direct Assay
more info
 PubMed 
part_of kinesin II complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of kinesin complex IEA
Inferred from Electronic Annotation
more info
  
located_in non-motile cilium IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
Kinesin-associated protein
NP_001367739.1
  • Confirmed by transcript evidence
NP_001367740.1
  • Partially confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003281.10 Reference assembly

    Range
    7338835..7343667
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001379791.1 → NP_001367739.1  Kinesin-associated protein [Caenorhabditis elegans]

    Status: REVIEWED

    UniProtKB/TrEMBL
    H2KZP1, Q9GV91
    Conserved Domains (1) summary
    pfam05804
    Location:5 → 690
    KAP; Kinesin-associated protein (KAP)

  2. NM_001379790.1 → NP_001367740.1  Kinesin-associated protein [Caenorhabditis elegans]

    Status: REVIEWED

    UniProtKB/TrEMBL
    G5EEE6, Q9GV91
    Conserved Domains (1) summary
    pfam05804
    Location:5 → 693
    KAP; Kinesin-associated protein (KAP)
Nucleotide Protein
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