hmgr-1 3-hydroxy-3-methylglutaryl coenzyme A reductase [Caenorhabditis elegans] - Gene

Summary

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Official Symbol: hmgr-1
Official Full Name: 3-hydroxy-3-methylglutaryl coenzyme A reductase
Primary source: WormBase:WBGene00017268
Locus tag: CELE_F08F8.2
See related: AllianceGenome:WB:WBGene00017268
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Caenorhabditis elegans (strain: Bristol N2)
Lineage: Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary: Predicted to enable hydroxymethylglutaryl-CoA reductase (NADPH) activity. Predicted to be involved in isoprenoid biosynthetic process and sterol biosynthetic process. Predicted to be located in endoplasmic reticulum. Predicted to be active in endoplasmic reticulum membrane and peroxisomal membrane. Is expressed in excretory cell; intestine; non-striated muscle; spermatheca; and ventral nerve cord. Human ortholog(s) of this gene implicated in several diseases, including attention deficit hyperactivity disorder; coronary artery disease (multiple); diabetes mellitus (multiple); muscular disease (multiple); and neurodegenerative disease (multiple). Orthologous to human HMGCR (3-hydroxy-3-methylglutaryl-CoA reductase). [provided by Alliance of Genome Resources, Jan 2025]
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Genomic context

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See hmgr-1 in Genome Data Viewer

Location:: chromosome: III

Exon count:: 7

Sequence:: Chromosome: III; NC_003281.10 (7359498..7362129)

Chromosome III - NC_003281.10 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003281.10

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

The hmgr-1(tm4368) Mutant Exhibits Reversible Decreased Protein Prenylation. The hmgr-1(tm4368) Mutant Exhibits Irreversible Muscle Mitochondria Disorganization.
Title: Loss of HMG-CoA reductase in C. elegans causes defects in protein prenylation and muscle mitochondria.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

F08F8.2 (e-PCR)
- UniSTS:309603

Homology

Orthologs from OrthoDB

Gene Ontology Provided by WormBase

Function	Evidence Code	Pubs
enables hydroxymethylglutaryl-CoA reductase (NADPH) activity	IBA Inferred from Biological aspect of Ancestor more info
enables hydroxymethylglutaryl-CoA reductase (NADPH) activity	IEA Inferred from Electronic Annotation more info
enables oxidoreductase activity	IEA Inferred from Electronic Annotation more info
enables oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in coenzyme A metabolic process	IEA Inferred from Electronic Annotation more info
involved_in isoprenoid biosynthetic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in isoprenoid biosynthetic process	IEA Inferred from Electronic Annotation more info
involved_in sterol biosynthetic process	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
located_in endoplasmic reticulum	IEA Inferred from Electronic Annotation more info
is_active_in endoplasmic reticulum membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in endoplasmic reticulum membrane	IEA Inferred from Electronic Annotation more info
is_active_in peroxisomal membrane	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: 3-hydroxy-3-methylglutaryl coenzyme A reductase

NP_498626.2

Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003281.10 Reference assembly

Range

7359498..7362129

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_066225.8 → NP_498626.2 3-hydroxy-3-methylglutaryl coenzyme A reductase [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_498626.2

Status: REVIEWED

UniProtKB/TrEMBL

Q19207

Conserved Domains (1) summary

cd00643
Location:102 → 500

HMG-CoA_reductase_classI; Class I hydroxymethylglutaryl-coenzyme A (HMG-CoA) reductase (HMGR)