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tbp-1 TATA-box-binding protein [ Caenorhabditis elegans ]

Gene ID: 176054, updated on 9-Dec-2024

Summary

Official Symbol
tbp-1
Official Full Name
TATA-box-binding protein
Primary source
WormBase:WBGene00006542
Locus tag
CELE_T20B12.2
See related
AllianceGenome:WB:WBGene00006542
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Enables DNA-binding transcription factor activity; RNA polymerase II general transcription initiation factor binding activity; and minor groove of adenine-thymine-rich DNA binding activity. Involved in positive regulation of DNA-templated transcription. Located in nucleus. Is expressed in gonad. Human ortholog(s) of this gene implicated in late onset Parkinson's disease; schizophrenia; spinocerebellar ataxia type 17; and type 1 diabetes mellitus. Orthologous to human TBP (TATA-box binding protein) and TBPL2 (TATA-box binding protein like 2). [provided by Alliance of Genome Resources, Dec 2024]
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Genomic context

See tbp-1 in Genome Data Viewer
Location:
chromosome: III
Exon count:
4
Sequence:
Chromosome: III; NC_003281.10 (7384033..7386124)

Chromosome III - NC_003281.10Genomic Context describing neighboring genes Neighboring gene FACT complex subunit SSRP1-A Neighboring gene Uncharacterized protein Neighboring gene Tetratricopeptide repeat-containing protein trd-1 Neighboring gene ncRNA Neighboring gene Ligand-gated ion channel 50 Neighboring gene ncRNA

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by WormBase

Process Evidence Code Pubs
involved_in DNA-templated transcription initiation IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in DNA-templated transcription initiation IEA
Inferred from Electronic Annotation
more info
 
involved_in positive regulation of DNA-templated transcription IDA
Inferred from Direct Assay
more info
PubMed 
involved_in transcription by RNA polymerase II ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in transcription by RNA polymerase III ISS
Inferred from Sequence or Structural Similarity
more info
 
Component Evidence Code Pubs
located_in nucleus IDA
Inferred from Direct Assay
more info
PubMed 
located_in nucleus IEA
Inferred from Electronic Annotation
more info
 
part_of transcription factor TFIID complex ISS
Inferred from Sequence or Structural Similarity
more info
 

General protein information

Preferred Names
TATA-box-binding protein
NP_001370645.1
  • Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003281.10 Reference assembly

    Range
    7384033..7386124
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001382915.2NP_001370645.1  TATA-box-binding protein [Caenorhabditis elegans]

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    P32085
    Conserved Domains (1) summary
    cd04516
    Location:165338
    TBP_eukaryotes; eukaryotic TATA box binding protein (TBP): Present in archaea and eukaryotes, TBPs are transcription factors that recognize promoters and initiate transcription. TBP has been shown to be an essential component of three different transcription initiation ...