fbn-1 EGF-like domain-containing protein [Caenorhabditis elegans] - Gene

Summary

Go to the top of the page Help

Official Symbol: fbn-1
Official Full Name: EGF-like domain-containing protein
Primary source: WormBase:WBGene00022816
Locus tag: CELE_ZK783.1
See related: AllianceGenome:WB:WBGene00022816
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Caenorhabditis elegans (strain: Bristol N2)
Lineage: Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary: Predicted to enable calcium ion binding activity. Predicted to be located in membrane. Is expressed in vulval cell. Used to study connective tissue disease. Human ortholog(s) of this gene implicated in several diseases, including CREST syndrome; Weill-Marchesani syndrome; aortic disease (multiple); autosomal dominant isolated ectopia lentis 1; and bone disease (multiple). Orthologous to human FBN1 (fibrillin 1); FBN2 (fibrillin 2); and FBN3 (fibrillin 3). [provided by Alliance of Genome Resources, Nov 2024]
NEW: Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help

See fbn-1 in Genome Data Viewer

Location:: chromosome: III

Exon count:: 25

Sequence:: Chromosome: III; NC_003281.10 (7625386..7641078)

Chromosome III - NC_003281.10 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to reference sequence details

Genomic Sequence:: NC_003281.10

Go to nucleotide: Graphics FASTA GenBank

Bibliography

Go to the top of the page Help

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

fbn-1 was required specifically within the epidermis and FBN-1 was expressed in epidermal cells and secreted to the apical surface as a putative component of the embryonic sheath.
Title: FBN-1, a fibrillin-related protein, is required for resistance of the epidermis to mechanical deformation during C. elegans embryogenesis.

Submit: New GeneRIF Correction

Interactions

Go to the top of the page Help

Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

Go to the top of the page Help

Markers

ZK783.1 (e-PCR)
- UniSTS:310544

Homology

Orthologs from OrthoDB

Gene Ontology Provided by WormBase

Function	Evidence Code	Pubs
enables calcium ion binding	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in membrane	IEA Inferred from Electronic Annotation more info

General protein information

Go to the top of the page Help

Preferred Names: EGF-like domain-containing protein

NP_001263709.1

Confirmed by transcript evidence

NP_001263711.1

Confirmed by transcript evidence

NP_001263712.1

Confirmed by transcript evidence

NP_001263714.1

Confirmed by transcript evidence

NP_001263715.1

Confirmed by transcript evidence

NP_001263716.1

Confirmed by transcript evidence

NP_001263717.1

Confirmed by transcript evidence

NP_001263718.1

Confirmed by transcript evidence

NP_498670.2

Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003281.10 Reference assembly

Range

7625386..7641078

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_066269.6 → NP_498670.2 EGF-like domain-containing protein [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_498670.2

Status: REVIEWED

UniProtKB/TrEMBL

G4SPX0, Q23587

Conserved Domains (8) summary

smart00179
Location:1699 → 1740

EGF_CA; Calcium-binding EGF-like domain

smart00241
Location:2344 → 2580

ZP; Zona pellucida (ZP) domain

cd00054
Location:1606 → 1640

EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...

pfam00100
Location:2484 → 2577

Zona_pellucida; Zona pellucida-like domain

pfam05109
Location:916 → 1381

Herpes_BLLF1; Herpes virus major outer envelope glycoprotein (BLLF1)

pfam07645
Location:220 → 255

EGF_CA; Calcium-binding EGF domain

pfam10310
Location:1274 → 1369

DUF2413; Protein of unknown function (DUF2413)

pfam12947
Location:2296 → 2331

EGF_3; EGF domain
NM_001276782.4 → NP_001263711.1 EGF-like domain-containing protein [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_001263711.1

Status: REVIEWED

UniProtKB/TrEMBL

I7J4C8

Conserved Domains (8) summary

smart00179
Location:1699 → 1740

EGF_CA; Calcium-binding EGF-like domain

smart00241
Location:2436 → 2672

ZP; Zona pellucida (ZP) domain

cd00054
Location:1606 → 1640

EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...

pfam00100
Location:2576 → 2669

Zona_pellucida; Zona pellucida-like domain

pfam05109
Location:916 → 1381

Herpes_BLLF1; Herpes virus major outer envelope glycoprotein (BLLF1)

pfam07645
Location:220 → 255

EGF_CA; Calcium-binding EGF domain

pfam10310
Location:1274 → 1369

DUF2413; Protein of unknown function (DUF2413)

pfam12947
Location:2388 → 2423

EGF_3; EGF domain
NM_001276783.3 → NP_001263712.1 EGF-like domain-containing protein [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_001263712.1

Status: REVIEWED

UniProtKB/TrEMBL

I7LHV8

Conserved Domains (8) summary

smart00179
Location:1699 → 1740

EGF_CA; Calcium-binding EGF-like domain

smart00241
Location:2413 → 2649

ZP; Zona pellucida (ZP) domain

cd00054
Location:1606 → 1640

EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...

pfam00100
Location:2553 → 2646

Zona_pellucida; Zona pellucida-like domain

pfam05109
Location:916 → 1381

Herpes_BLLF1; Herpes virus major outer envelope glycoprotein (BLLF1)

pfam07645
Location:220 → 255

EGF_CA; Calcium-binding EGF domain

pfam10310
Location:1274 → 1369

DUF2413; Protein of unknown function (DUF2413)

pfam12947
Location:2365 → 2400

EGF_3; EGF domain
NM_001276787.4 → NP_001263716.1 EGF-like domain-containing protein [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_001263716.1

Status: REVIEWED

UniProtKB/TrEMBL

I7J4C9

Conserved Domains (8) summary

smart00179
Location:1699 → 1740

EGF_CA; Calcium-binding EGF-like domain

smart00241
Location:2313 → 2549

ZP; Zona pellucida (ZP) domain

cd00054
Location:1606 → 1640

EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...

pfam00100
Location:2453 → 2546

Zona_pellucida; Zona pellucida-like domain

pfam05109
Location:916 → 1381

Herpes_BLLF1; Herpes virus major outer envelope glycoprotein (BLLF1)

pfam07645
Location:220 → 255

EGF_CA; Calcium-binding EGF domain

pfam10310
Location:1274 → 1369

DUF2413; Protein of unknown function (DUF2413)

pfam12947
Location:2265 → 2300

EGF_3; EGF domain
NM_001276780.3 → NP_001263709.1 EGF-like domain-containing protein [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_001263709.1

Status: REVIEWED

UniProtKB/TrEMBL

I6Z0I7

Conserved Domains (8) summary

smart00179
Location:1701 → 1742

EGF_CA; Calcium-binding EGF-like domain

smart00241
Location:2438 → 2674

ZP; Zona pellucida (ZP) domain

cd00054
Location:1608 → 1642

EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...

pfam00100
Location:2578 → 2671

Zona_pellucida; Zona pellucida-like domain

pfam05109
Location:918 → 1383

Herpes_BLLF1; Herpes virus major outer envelope glycoprotein (BLLF1)

pfam07645
Location:220 → 255

EGF_CA; Calcium-binding EGF domain

pfam10310
Location:1276 → 1371

DUF2413; Protein of unknown function (DUF2413)

pfam12947
Location:2390 → 2425

EGF_3; EGF domain
NM_001276785.3 → NP_001263714.1 EGF-like domain-containing protein [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_001263714.1

Status: REVIEWED

UniProtKB/TrEMBL

I7K4J2

Conserved Domains (8) summary

smart00179
Location:1699 → 1740

EGF_CA; Calcium-binding EGF-like domain

smart00241
Location:2391 → 2627

ZP; Zona pellucida (ZP) domain

cd00054
Location:1606 → 1640

EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...

pfam00100
Location:2531 → 2624

Zona_pellucida; Zona pellucida-like domain

pfam05109
Location:916 → 1381

Herpes_BLLF1; Herpes virus major outer envelope glycoprotein (BLLF1)

pfam07645
Location:220 → 255

EGF_CA; Calcium-binding EGF domain

pfam10310
Location:1274 → 1369

DUF2413; Protein of unknown function (DUF2413)

pfam12947
Location:2343 → 2378

EGF_3; EGF domain
NM_001276786.3 → NP_001263715.1 EGF-like domain-containing protein [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_001263715.1

Status: REVIEWED

UniProtKB/TrEMBL

I7LFE6

Conserved Domains (8) summary

smart00179
Location:1699 → 1740

EGF_CA; Calcium-binding EGF-like domain

smart00241
Location:2360 → 2596

ZP; Zona pellucida (ZP) domain

cd00054
Location:1606 → 1640

EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...

pfam00100
Location:2500 → 2593

Zona_pellucida; Zona pellucida-like domain

pfam05109
Location:916 → 1381

Herpes_BLLF1; Herpes virus major outer envelope glycoprotein (BLLF1)

pfam07645
Location:220 → 255

EGF_CA; Calcium-binding EGF domain

pfam10310
Location:1274 → 1369

DUF2413; Protein of unknown function (DUF2413)

pfam12947
Location:2312 → 2347

EGF_3; EGF domain
NM_001276788.3 → NP_001263717.1 EGF-like domain-containing protein [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_001263717.1

Status: REVIEWED

UniProtKB/TrEMBL

I7LHV9

Conserved Domains (8) summary

smart00179
Location:1699 → 1740

EGF_CA; Calcium-binding EGF-like domain

smart00241
Location:2338 → 2574

ZP; Zona pellucida (ZP) domain

cd00054
Location:1606 → 1640

EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...

pfam00100
Location:2478 → 2571

Zona_pellucida; Zona pellucida-like domain

pfam05109
Location:916 → 1381

Herpes_BLLF1; Herpes virus major outer envelope glycoprotein (BLLF1)

pfam07645
Location:220 → 255

EGF_CA; Calcium-binding EGF domain

pfam10310
Location:1274 → 1369

DUF2413; Protein of unknown function (DUF2413)

pfam12947
Location:2290 → 2325

EGF_3; EGF domain
NM_001276789.4 → NP_001263718.1 EGF-like domain-containing protein [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_001263718.1

Status: REVIEWED

UniProtKB/TrEMBL

I7K4J6

Conserved Domains (6) summary

PHA03255
Location:2032 → 2171

PHA03255; BDLF3; Provisional

smart00179
Location:1699 → 1740

EGF_CA; Calcium-binding EGF-like domain

cd00054
Location:1606 → 1640

EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...

pfam07645
Location:220 → 255

EGF_CA; Calcium-binding EGF domain

pfam10310
Location:1274 → 1369

DUF2413; Protein of unknown function (DUF2413)

pfam12947
Location:140 → 170

EGF_3; EGF domain