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upp-1 Uridine and thymidine phosphorylase [ Caenorhabditis elegans ]

Gene ID: 176077, updated on 2-Nov-2024

Summary

Official Symbol
upp-1
Official Full Name
Uridine and thymidine phosphorylase
Primary source
WormBase:WBGene00022817
Locus tag
CELE_ZK783.2
See related
AllianceGenome:WB:WBGene00022817
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Enables thymidine phosphorylase activity and uridine phosphorylase activity. Involved in thymidine metabolic process; uracil catabolic process; and uridine catabolic process. Predicted to be located in cytoplasm. Predicted to be active in cytosol. Is expressed in gonad; hypodermis; and pharynx. Orthologous to human UPP1 (uridine phosphorylase 1) and UPP2 (uridine phosphorylase 2). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

See upp-1 in Genome Data Viewer
Location:
chromosome: III
Exon count:
4
Sequence:
Chromosome: III; NC_003281.10 (7641034..7643101, complement)

Chromosome III - NC_003281.10Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene EGF-like domain-containing protein Neighboring gene tRNA-Glu Neighboring gene ncRNA Neighboring gene pseudo Neighboring gene pseudo

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
enables catalytic activity IEA
Inferred from Electronic Annotation
more info
 
enables deoxyuridine phosphorylase activity IEA
Inferred from Electronic Annotation
more info
 
enables glycosyltransferase activity IEA
Inferred from Electronic Annotation
more info
 
enables pyrimidine-nucleoside phosphorylase activity IEA
Inferred from Electronic Annotation
more info
 
enables thymidine phosphorylase activity IDA
Inferred from Direct Assay
more info
PubMed 
enables thymidine phosphorylase activity IEA
Inferred from Electronic Annotation
more info
 
enables uridine phosphorylase activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables uridine phosphorylase activity IDA
Inferred from Direct Assay
more info
PubMed 
enables uridine phosphorylase activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
involved_in UMP salvage IEA
Inferred from Electronic Annotation
more info
 
involved_in nucleoside metabolic process IEA
Inferred from Electronic Annotation
more info
 
involved_in nucleotide catabolic process IEA
Inferred from Electronic Annotation
more info
 
involved_in pyrimidine nucleotide biosynthetic process IEA
Inferred from Electronic Annotation
more info
 
involved_in thymidine metabolic process IDA
Inferred from Direct Assay
more info
PubMed 
involved_in uracil catabolic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in uracil metabolic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in uridine catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in uridine catabolic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in uridine metabolic process IDA
Inferred from Direct Assay
more info
PubMed 
involved_in uridine metabolic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
 
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
 

General protein information

Preferred Names
Uridine and thymidine phosphorylase
NP_498671.2
  • Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003281.10 Reference assembly

    Range
    7641034..7643101 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_066270.7NP_498671.2  Uridine and thymidine phosphorylase [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_498671.2

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q23588
    Conserved Domains (1) summary
    cl00303
    Location:14295
    PNP_UDP_1; Phosphorylase superfamily