unc-86 Transcription factor unc-86 [Caenorhabditis elegans] - Gene

Summary

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Official Symbol: unc-86
Official Full Name: Transcription factor unc-86
Primary source: WormBase:WBGene00006818
Locus tag: CELE_C30A5.7
See related: AllianceGenome:WB:WBGene00006818
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Caenorhabditis elegans (strain: Bristol N2)
Lineage: Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary: Enables DNA-binding transcription activator activity, RNA polymerase II-specific; RNA polymerase II transcription regulatory region sequence-specific DNA binding activity; and RNA polymerase II-specific DNA-binding transcription factor binding activity. Involved in mechanosensory behavior; neuron differentiation; and positive regulation of transcription by RNA polymerase II. Located in nucleus. Part of RNA polymerase II transcription regulator complex. Is expressed in neurons. Human ortholog(s) of this gene implicated in autosomal dominant nonsyndromic deafness 15. Orthologous to human POU4F1 (POU class 4 homeobox 1); POU4F2 (POU class 4 homeobox 2); and POU4F3 (POU class 4 homeobox 3). [provided by Alliance of Genome Resources, Jan 2025]
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Genomic context

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See unc-86 in Genome Data Viewer

Location:: chromosome: III

Exon count:: 6

Sequence:: Chromosome: III; NC_003281.10 (8212740..8216336, complement)

Chromosome III - NC_003281.10 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003281.10

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Brn3/POU-IV-type POU homeobox genes-Paradigmatic regulators of neuronal identity across phylogeny.
Title: Brn3/POU-IV-type POU homeobox genes-Paradigmatic regulators of neuronal identity across phylogeny.
the type of differentiation program that is controlled by ttx-3 in different neuron types is specified by a distinct set of collaborating transcription factors, including the POU homeobox gene unc-86
Title: The LIM and POU homeobox genes ttx-3 and unc-86 act as terminal selectors in distinct cholinergic and serotonergic neuron types.
Data propose that unc-86(lf) HSN axons are misguided due to the temporal decoupling of axon initiation and ventral guidance responses.
Title: The POU transcription factor UNC-86 controls the timing and ventral guidance of Caenorhabditis elegans axon growth.
UNC-86 POU transcription factor modulates olfactory sensitivity
Title: Activity of the Caenorhabditis elegans UNC-86 POU transcription factor modulates olfactory sensitivity.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

C30A5.7 (e-PCR)
- UniSTS:318885

Homology

Orthologs from OrthoDB

Gene Ontology Provided by WormBase

Function	Evidence Code	Pubs
enables DNA binding	IEA Inferred from Electronic Annotation more info
enables DNA-binding transcription activator activity, RNA polymerase II-specific	IDA Inferred from Direct Assay more info	PubMed
enables DNA-binding transcription factor activity	IEA Inferred from Electronic Annotation more info
enables DNA-binding transcription factor activity, RNA polymerase II-specific	IBA Inferred from Biological aspect of Ancestor more info
enables DNA-binding transcription factor activity, RNA polymerase II-specific	IDA Inferred from Direct Assay more info	PubMed
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	IBA Inferred from Biological aspect of Ancestor more info
enables RNA polymerase II transcription regulatory region sequence-specific DNA binding	IDA Inferred from Direct Assay more info	PubMed
enables RNA polymerase II-specific DNA-binding transcription factor binding	IPI Inferred from Physical Interaction more info	PubMed
enables sequence-specific DNA binding	IDA Inferred from Direct Assay more info	PubMed

Process	Evidence Code	Pubs
involved_in cell differentiation	IEA Inferred from Electronic Annotation more info
involved_in mechanosensory behavior	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in nervous system development	IEA Inferred from Electronic Annotation more info
involved_in neuron development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in neuron fate specification	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of transcription by RNA polymerase II	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of transcription by RNA polymerase II	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of DNA-templated transcription	IEA Inferred from Electronic Annotation more info
involved_in regulation of transcription by RNA polymerase II	IBA Inferred from Biological aspect of Ancestor more info
involved_in response to mechanical stimulus	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in response to stimulus	IEA Inferred from Electronic Annotation more info
involved_in sensory perception of smell	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
part_of RNA polymerase II transcription regulator complex	IDA Inferred from Direct Assay more info	PubMed
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed
located_in nucleus	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: Transcription factor unc-86

NP_001021191.2

Confirmed by transcript evidence

NP_001309473.1

Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003281.10 Reference assembly

Range

8212740..8216336 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001322687.4 → NP_001309473.1 Transcription factor unc-86 [Caenorhabditis elegans]

Status: REVIEWED

UniProtKB/Swiss-Prot

P13528

Conserved Domains (2) summary

smart00352
Location:99 → 176

POU; Found in Pit-Oct-Unc transcription factors

pfam00046
Location:200 → 253

Homeobox; Homeobox domain
NM_001026020.7 → NP_001021191.2 Transcription factor unc-86 [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_001021191.2

Status: REVIEWED

UniProtKB/Swiss-Prot

D7SFI2, P13528

Conserved Domains (2) summary

smart00352
Location:155 → 232

POU; Found in Pit-Oct-Unc transcription factors

pfam00046
Location:256 → 309

Homeobox; Homeobox domain