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ncr-2 NPC intracellular cholesterol transporter 1 homolog 2 [ Caenorhabditis elegans ]

Gene ID: 176165, updated on 9-Dec-2024

Summary

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Official Symbol
ncr-2
Official Full Name
NPC intracellular cholesterol transporter 1 homolog 2
Primary source
WormBase:WBGene00003562
Locus tag
CELE_F09G8.4
See related
AllianceGenome:WB:WBGene00003562
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Predicted to enable cholesterol binding activity. Involved in cholesterol homeostasis; cholesterol transport; and nematode larval development. Predicted to be located in membrane. Predicted to be active in plasma membrane. Is expressed in XXXL; XXXR; gonadal sheath cell; spermatheca; and ventral nerve cord. Used to study Niemann-Pick disease. Human ortholog(s) of this gene implicated in Niemann-Pick disease type C1. Orthologous to human NPC1 (NPC intracellular cholesterol transporter 1). [provided by Alliance of Genome Resources, Dec 2024]
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Genomic context

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See ncr-2 in Genome Data Viewer
Location:
chromosome: III
Exon count:
19
Sequence:
Chromosome: III; NC_003281.10 (8258345..8265805)

Chromosome III - NC_003281.10Genomic Context describing neighboring genes Neighboring gene Outer kinetochore KNL1 complex subunit knl-1 Neighboring gene Uncharacterized protein Neighboring gene Putative cuticle collagen 91 Neighboring gene Small ribosomal subunit protein uS9m Neighboring gene Uncharacterized protein

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003281.10

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Mutations in NPC1 in two Brazilian patients with Niemann-Pick disease type C and progressive supranuclear palsy-like presentation. Godeiro-Júnior C, et al. Mov Disord, 2006 Dec. PMID 17044092
  2. A model for niemann-pick type C disease in the nematode Caenorhabditis elegans. Sym M, et al. Curr Biol, 2000 May 4. PMID 10801441
  3. CUP-1 is a novel protein involved in dietary cholesterol uptake in Caenorhabditis elegans. Valdes VJ, et al. PLoS One, 2012. PMID 22479487, Free PMC Article
  4. NCR-1 and NCR-2, the C. elegans homologs of the human Niemann-Pick type C1 disease protein, function upstream of DAF-9 in the dauer formation pathways. Li J, et al. Development, 2004 Nov. PMID 15509773
  5. Human NPC1L1 and NPC1 can functionally substitute for the ncr genes to promote reproductive development in C. elegans. Smith MM, et al. Biochim Biophys Acta, 2007 Sep. PMID 17662536

See all (22) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Mutations in NPC1 in two Brazilian patients with Niemann-Pick disease type C and progressive supranuclear palsy-like presentation.
    Title: Mutations in NPC1 in two Brazilian patients with Niemann-Pick disease type C and progressive supranuclear palsy-like presentation.
Submit: New GeneRIF Correction

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
enables cholesterol binding IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in cholesterol homeostasis IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in cholesterol homeostasis IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in cholesterol transport IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in dauer larval development IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in intestinal cholesterol absorption IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in lipid transport IEA
Inferred from Electronic Annotation
more info
  
involved_in sterol transport IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in vulval development IGI
Inferred from Genetic Interaction
more info
 PubMed 
Component Evidence Code Pubs
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
NPC intracellular cholesterol transporter 1 homolog 2
NP_498813.1
  • Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003281.10 Reference assembly

    Range
    8258345..8265805
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_066412.4 → NP_498813.1  NPC intracellular cholesterol transporter 1 homolog 2 [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_498813.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    P34389, Q8MYQ6
    Conserved Domains (3) summary
    TIGR00917
    Location:85 → 1236
    2A060601; Niemann-Pick C type protein family
    pfam16414
    Location:29 → 242
    NPC1_N; Niemann-Pick C1 N terminus
    cl21543
    Location:619 → 783
    MMPL; MMPL family
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P34389.2

Gene LinkOut

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