U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

crn-7 Cell-death-related nuclease 7 [ Caenorhabditis elegans ]

Gene ID: 176166, updated on 9-Dec-2024

Summary

Go to the top of the page Help
Official Symbol
crn-7
Official Full Name
Cell-death-related nuclease 7
Primary source
WormBase:WBGene00007056
Locus tag
CELE_F09G8.2
See related
AllianceGenome:WB:WBGene00007056
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Enables deoxyribonuclease II activity. Involved in apoptotic DNA fragmentation. Acts upstream of or within with a positive effect on negative regulation of antimicrobial peptide production. Is expressed in body wall musculature. Orthologous to human DNASE2 (deoxyribonuclease 2, lysosomal). [provided by Alliance of Genome Resources, Dec 2024]
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
See crn-7 in Genome Data Viewer
Location:
chromosome: III
Exon count:
6
Sequence:
Chromosome: III; NC_003281.10 (8268531..8270684)

Chromosome III - NC_003281.10Genomic Context describing neighboring genes Neighboring gene Small ribosomal subunit protein uS9m Neighboring gene Uncharacterized protein Neighboring gene MinK-related peptide, potassium channel accessory subunit protein 4 Neighboring gene Uncharacterized protein Neighboring gene C-type lectin domain-containing protein 160

Genomic regions, transcripts, and products

Go to the top of the page Help
Genomic Sequence:
NC_003281.10

Go to nucleotide: Graphics FASTA GenBank

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. An arrhythmia susceptibility gene in Caenorhabditis elegans. Park KH, et al. J Biol Chem, 2007 Jul 6. PMID 17491013
  2. Autonomous and non-autonomous roles of DNase II during cell death in C. elegans embryos. Yu H, et al. Biosci Rep, 2015 Apr 27. PMID 26182365, Free PMC Article
  3. The roles and acting mechanism of Caenorhabditis elegans DNase II genes in apoptotic dna degradation and development. Lai HJ, et al. PLoS One, 2009 Oct 7. PMID 19809494, Free PMC Article
  4. Loss of DNase II function in the gonad is associated with a higher expression of antimicrobial genes in Caenorhabditis elegans. Yu H, et al. Biochem J, 2015 Aug 15. PMID 26251453
  5. A genomewide RNAi screen for genes that affect the stability, distribution and function of P granules in Caenorhabditis elegans. Updike DL, et al. Genetics, 2009 Dec. PMID 19805813, Free PMC Article

See all (8) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. CRN-7 was found to play a role in degrading apoptotic DNA in distinct sites of the gonad.
    Title: Loss of DNase II function in the gonad is associated with a higher expression of antimicrobial genes in Caenorhabditis elegans.
Submit: New GeneRIF Correction

General gene information

Go to the top of the page Help

Markers

Homology

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
enables deoxyribonuclease II activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables deoxyribonuclease II activity IEA
Inferred from Electronic Annotation
more info
  
enables deoxyribonuclease II activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
enables hydrolase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in DNA metabolic process IEA
Inferred from Electronic Annotation
more info
  
involved_in apoptotic DNA fragmentation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in apoptotic DNA fragmentation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within_positive_effect negative regulation of antimicrobial peptide production IMP
Inferred from Mutant Phenotype
more info
 PubMed 

General protein information

Go to the top of the page Help
Preferred Names
Cell-death-related nuclease 7
NP_498817.1
  • Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003281.10 Reference assembly

    Range
    8268531..8270684
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_066416.4 → NP_498817.1  Cell-death-related nuclease 7 [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_498817.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    P34387, Q9NCF7
    Conserved Domains (3) summary
    cd09120
    Location:18 → 155
    PLDc_DNaseII_1; Catalytic domain, repeat 1, of Deoxyribonuclease II and similar proteins
    cd09121
    Location:204 → 342
    PLDc_DNaseII_2; Catalytic domain, repeat 2, of Deoxyribonuclease II and similar proteins
    pfam03265
    Location:21 → 340
    DNase_II; Deoxyribonuclease II
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P34387.2

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Chemical Information
Molecular Biology Databases
Research Materials
Tools
Miscellaneous