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ubxn-4 UBX domain-containing protein 4 [ Caenorhabditis elegans ]

Gene ID: 176187, updated on 2-Nov-2024

Summary

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Official Symbol
ubxn-4
Official Full Name
UBX domain-containing protein 4
Primary source
WormBase:WBGene00022703
Locus tag
CELE_ZK353.8
See related
AllianceGenome:WB:WBGene00022703
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Involved in ERAD pathway. Predicted to be located in endoplasmic reticulum membrane. Predicted to be active in endoplasmic reticulum. Orthologous to human UBXN4 (UBX domain protein 4). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See ubxn-4 in Genome Data Viewer
Location:
chromosome: III
Exon count:
5
Sequence:
Chromosome: III; NC_003281.10 (8403718..8405422, complement)

Chromosome III - NC_003281.10Genomic Context describing neighboring genes Neighboring gene Uncharacterized protein Neighboring gene Leucine aminopeptidase 1 Neighboring gene Copper homeostasis protein cutC homolog Neighboring gene Cyclin-Y Neighboring gene PITH domain-containing protein ZK353.9

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003281.10

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Differential expression pattern of UBX family genes in Caenorhabditis elegans. Yamauchi S, et al. Biochem Biophys Res Commun, 2007 Jun 29. PMID 17498661
  2. RNA polymerase II CTD S2P is dispensable for embryogenesis but mediates exit from developmental diapause in C. elegans. Cassart C, et al. Sci Adv, 2020 Dec. PMID 33298437, Free PMC Article
  3. Caenorhabditis elegans UBX cofactors for CDC-48/p97 control spermatogenesis. Sasagawa Y, et al. Genes Cells, 2010 Dec. PMID 20977550
  4. Ubiquilin and p97/VCP bind erasin, forming a complex involved in ERAD. Lim PJ, et al. J Cell Biol, 2009 Oct 19. PMID 19822669, Free PMC Article
  5. Amino acid and protein specificity of protein fatty acylation in C. elegans. Zhang B, et al. Proc Natl Acad Sci U S A, 2024 Jan 30. PMID 38252833, Free PMC Article

See all (9) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in ERAD pathway IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in ERAD pathway IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in response to unfolded protein IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
is_active_in endoplasmic reticulum IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in endoplasmic reticulum IEA
Inferred from Electronic Annotation
more info
  
located_in endoplasmic reticulum membrane IEA
Inferred from Electronic Annotation
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
UBX domain-containing protein 4
NP_001370812.1
  • Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003281.10 Reference assembly

    Range
    8403718..8405422 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001382940.2 → NP_001370812.1  UBX domain-containing protein 4 [Caenorhabditis elegans]

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    P34631
    Conserved Domains (3) summary
    PRK05641
    Location:85 → 159
    PRK05641; putative acetyl-CoA carboxylase biotin carboxyl carrier protein subunit; Validated
    TIGR02794
    Location:167 → 252
    tolA_full; TolA protein
    cd16117
    Location:282 → 358
    UBX_UBXN4; Ubiquitin regulatory domain X (UBX) found in UBX domain protein 4 (UBXN4) and similar proteins
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P34631.1

Gene LinkOut

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