pac-1 GTPase-activating protein pac-1;PH domain-containing protein;Rho-GAP domain-containing protein [Caenorhabditis elegans] - Gene

Summary

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Official Symbol: pac-1
Official Full Name: GTPase-activating protein pac-1;PH domain-containing protein;Rho-GAP domain-containing protein
Primary source: WormBase:WBGene00015418
Locus tag: CELE_C04D8.1
See related: AllianceGenome:WB:WBGene00015418
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Caenorhabditis elegans (strain: Bristol N2)
Lineage: Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary: Enables GTPase activator activity. Involved in protein localization; regulation of gastrulation; and small GTPase-mediated signal transduction. Located in cell junction. Is expressed in anus; epithelial cell; hypodermis; muscle cell; and pharynx. Orthologous to human ARHGAP23 (Rho GTPase activating protein 23). [provided by Alliance of Genome Resources, Jan 2025]
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Genomic context

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See pac-1 in Genome Data Viewer

Location:: chromosome: III

Exon count:: 20

Sequence:: Chromosome: III; NC_003281.10 (8495008..8518916)

Chromosome III - NC_003281.10 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003281.10

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

study identified a RhoGAP, PAC-1, which mediates embryo radial polarity & gastrulation by excluding PAR-6 from contacted cell surfaces; PAC-1 provides a dynamic molecular link between cell contacts & PAR proteins that polarizes embryos radially
Title: Polarization of the C. elegans embryo by RhoGAP-mediated exclusion of PAR-6 from cell contacts.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

STS3-172 (e-PCR)
- UniSTS:242015

C04D8.1 (e-PCR)
- UniSTS:308919

Homology

Orthologs from OrthoDB

Gene Ontology Provided by WormBase

Function	Evidence Code	Pubs
enables GTPase activator activity	IBA Inferred from Biological aspect of Ancestor more info
enables GTPase activator activity	IDA Inferred from Direct Assay more info	PubMed
enables GTPase activator activity	IEA Inferred from Electronic Annotation more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in Ras protein signal transduction	IDA Inferred from Direct Assay more info	PubMed
involved_in Rho protein signal transduction	IDA Inferred from Direct Assay more info	PubMed
involved_in protein localization	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of gastrulation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in signal transduction	IEA Inferred from Electronic Annotation more info
involved_in small GTPase-mediated signal transduction	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
located_in adherens junction	IEA Inferred from Electronic Annotation more info
located_in anchoring junction	IEA Inferred from Electronic Annotation more info
located_in cell junction	IDA Inferred from Direct Assay more info	PubMed
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: GTPase-activating protein pac-1;PH domain-containing protein;Rho-GAP domain-containing protein

NP_001129833.1

Confirmed by transcript evidence

NP_001293654.1

Confirmed by transcript evidence

NP_001293655.1

Confirmed by transcript evidence

NP_001293656.1

Partially confirmed by transcript evidence

NP_001293657.1

Confirmed by transcript evidence

NP_498877.4

Partially confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003281.10 Reference assembly

Range

8495008..8518916

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001306728.4 → NP_001293657.1 GTPase-activating protein pac-1 [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_001293657.1

Status: REVIEWED

UniProtKB/TrEMBL

U4PRC7

Conserved Domains (3) summary

cd04395
Location:944 → 1145

RhoGAP_ARHGAP21; RhoGAP_ARHGAP21: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of ArhGAP21-like proteins. ArhGAP21 is a multi-domain protein, containing RhoGAP, PH and PDZ domains, and is believed to play a role in the organization of the ...

cd01253
Location:612 → 727

PH_ARHGAP21-like; ARHGAP21 and related proteins pleckstrin homology (PH) domain

pfam00169
Location:616 → 725

PH; PH domain
NM_001136361.5 → NP_001129833.1 GTPase-activating protein pac-1 [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_001129833.1

Status: REVIEWED

UniProtKB/Swiss-Prot

P34288

Conserved Domains (3) summary

cd04395
Location:944 → 1145

RhoGAP_ARHGAP21; RhoGAP_ARHGAP21: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of ArhGAP21-like proteins. ArhGAP21 is a multi-domain protein, containing RhoGAP, PH and PDZ domains, and is believed to play a role in the organization of the ...

cd01253
Location:612 → 727

PH_ARHGAP21-like; ARHGAP21 and related proteins pleckstrin homology (PH) domain

pfam00169
Location:616 → 725

PH; PH domain
NM_066476.7 → NP_498877.4 GTPase-activating protein pac-1 [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_498877.4

Status: REVIEWED

UniProtKB/Swiss-Prot

B3VIA5, B5MBW1, P34288, P34414, P34588, P34589, Q8ST20, Q9TY64

Conserved Domains (2) summary

cd04395
Location:945 → 1146

RhoGAP_ARHGAP21; RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of ArhGAP21-like proteins. ArhGAP21 is a multi-domain protein, containing RhoGAP, PH and PDZ domains, and is believed to play a role in the organization of the cell-cell junction ...

cd01253
Location:613 → 728

PH_ARHGAP21-like; ARHGAP21 and related proteins pleckstrin homology (PH) domain
NM_001306727.4 → NP_001293656.1 PH domain-containing protein [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_001293656.1

Status: REVIEWED

UniProtKB/TrEMBL

U4PM34

Conserved Domains (3) summary

cd04395
Location:583 → 784

RhoGAP_ARHGAP21; RhoGAP_ARHGAP21: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of ArhGAP21-like proteins. ArhGAP21 is a multi-domain protein, containing RhoGAP, PH and PDZ domains, and is believed to play a role in the organization of the ...

cd01253
Location:251 → 366

PH_ARHGAP21-like; ARHGAP21 and related proteins pleckstrin homology (PH) domain

pfam00169
Location:255 → 364

PH; PH domain
NM_001306725.3 → NP_001293654.1 PH domain-containing protein [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_001293654.1

Status: REVIEWED

UniProtKB/TrEMBL

U4PBA1

Conserved Domains (3) summary

cd04395
Location:478 → 679

RhoGAP_ARHGAP21; RhoGAP_ARHGAP21: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of ArhGAP21-like proteins. ArhGAP21 is a multi-domain protein, containing RhoGAP, PH and PDZ domains, and is believed to play a role in the organization of the ...

cd01253
Location:146 → 261

PH_ARHGAP21-like; ARHGAP21 and related proteins pleckstrin homology (PH) domain

pfam00169
Location:150 → 259

PH; PH domain
NM_001306726.3 → NP_001293655.1 Rho-GAP domain-containing protein [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_001293655.1

Status: REVIEWED

UniProtKB/TrEMBL

U4PBN0

Conserved Domains (1) summary

cd04395
Location:106 → 307

RhoGAP_ARHGAP21; RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of ArhGAP21-like proteins. ArhGAP21 is a multi-domain protein, containing RhoGAP, PH and PDZ domains, and is believed to play a role in the organization of the cell-cell junction ...